Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   BWR56_RS00015 Genome accession   NZ_CP019562
Coordinates   2395..3591 (-) Length   398 a.a.
NCBI ID   WP_049505014.1    Uniprot ID   A0A1L8Q4B3
Organism   Streptococcus oralis strain S.MIT/ORALIS-351     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1..8591
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BWR56_RS00005 (BWR56_0001) dnaA 1..1362 (-) 1362 WP_061421574.1 chromosomal replication initiator protein DnaA -
  BWR56_RS00010 (BWR56_0002) spo0J 1579..2337 (-) 759 WP_049505012.1 ParB/RepB/Spo0J family partition protein Regulator
  BWR56_RS00015 (BWR56_0003) htrA 2395..3591 (-) 1197 WP_049505014.1 S1C family serine protease Regulator
  BWR56_RS00020 (BWR56_0004) rlmH 3777..4256 (+) 480 WP_049505015.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  BWR56_RS00030 (BWR56_0006) comC/comC1 4538..4663 (+) 126 WP_008282505.1 competence-stimulating peptide ComC Regulator
  BWR56_RS00035 (BWR56_0007) comD 4684..6003 (+) 1320 WP_049505018.1 competence system sensor histidine kinase ComD Regulator
  BWR56_RS00040 (BWR56_0008) comE 6000..6752 (+) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  BWR56_RS00055 (BWR56_0011) - 6990..7532 (-) 543 WP_049477913.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 398 a.a.        Molecular weight: 42012.83 Da        Isoelectric Point: 6.3586

>NTDB_id=216286 BWR56_RS00015 WP_049505014.1 2395..3591(-) (htrA) [Streptococcus oralis strain S.MIT/ORALIS-351]
MKHLQKFYKKGVKILVIILIGFLSGALGSFVTLQLYQKQGNQATNNNSGTVTQTSYKNENSTTQAVNKVKDAVVSIITYS
SSSSRQSSVFNADETNSDSDNQQIASEGSGVIYKKDDKDAYLVTNTHVINGASKVDIRLADGTKVPGEIVGSDTFSDIAV
VKISSEKVTTVAEFGDSSQLSVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSG
GPLVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESDGKVTRPALGIQMVNLSNVGASDLRKLNIPSGL
TSGVVVRSVQNNMPANGHLQKYDVITKVDDKEIASSTDLQHALYNHAIGDTIKITYYRNGKEETTSIKLDKNSGDLES

Nucleotide


Download         Length: 1197 bp        

>NTDB_id=216286 BWR56_RS00015 WP_049505014.1 2395..3591(-) (htrA) [Streptococcus oralis strain S.MIT/ORALIS-351]
ATGAAACACTTACAAAAATTTTACAAAAAAGGAGTTAAAATTCTCGTAATCATTCTAATCGGATTTTTAAGCGGTGCCTT
AGGAAGTTTCGTAACATTACAACTTTATCAAAAACAAGGAAATCAAGCTACAAATAATAATTCTGGCACTGTCACTCAAA
CATCCTATAAGAATGAAAATTCAACCACTCAAGCAGTAAATAAAGTTAAGGATGCTGTTGTCTCAATCATTACTTATTCT
TCTTCTAGCAGTAGACAAAGTAGTGTATTTAATGCTGATGAAACTAATTCTGATTCAGACAATCAACAAATCGCAAGTGA
GGGATCAGGTGTTATCTATAAAAAGGATGATAAAGATGCCTATCTTGTAACCAATACTCACGTTATCAATGGAGCTTCAA
AAGTTGATATCCGCTTAGCAGATGGTACCAAGGTTCCTGGTGAAATTGTCGGATCTGATACCTTCTCTGATATTGCTGTC
GTTAAAATTTCTTCAGAAAAAGTTACAACAGTGGCAGAATTTGGGGATTCAAGTCAACTTAGTGTTGGAGAAACAGCGAT
TGCTATCGGTAGTCCTCTAGGTTCAGAATATGCTAATACAGTTACACAGGGGATTGTTTCAAGTCTTAATCGAAATGTTT
CTCTAAAATCTGAAGATGGTCAAGCTATTTCAACAAAAGCCATTCAAACAGATACGGCCATTAACCCTGGTAACTCTGGT
GGTCCACTTGTAAATATTCAAGGACAAGTAATTGGTATTACATCAAGTAAAATTGCAAGTAATGGTGGAACATCTGTAGA
AGGTCTTGGTTTTGCAATTCCTTCAAACGATGCACAAAATATCATTAAACAGCTTGAAAGTGATGGTAAAGTGACTCGTC
CTGCTCTTGGAATTCAAATGGTCAATCTGTCAAATGTTGGAGCTAGTGATCTTAGAAAACTTAACATTCCAAGTGGCCTC
ACTTCAGGTGTAGTTGTTCGATCTGTTCAAAACAATATGCCAGCAAATGGACATCTTCAAAAATACGATGTCATTACCAA
AGTTGACGACAAAGAGATTGCCTCATCAACAGACCTACAACATGCTCTTTACAATCATGCTATTGGAGATACTATCAAAA
TAACCTACTACCGTAACGGTAAGGAGGAAACAACTTCAATTAAACTAGATAAGAATTCTGGTGATTTAGAGTCTTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(294-389)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

Peptidase family M50 (Peptidase_M50)

(236-393)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1L8Q4B3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

84.171

100

0.842
  htrA Streptococcus pneumoniae Rx1

83.417

100

0.834
  htrA Streptococcus pneumoniae D39

83.417

100

0.834
  htrA Streptococcus pneumoniae R6

83.417

100

0.834
  htrA Streptococcus pneumoniae TIGR4

83.417

100

0.834
  htrA Streptococcus gordonii str. Challis substr. CH1

66.418

100

0.671
  htrA Streptococcus mutans UA159

54.822

98.995

0.543

Multiple sequence alignment