Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   U8955_RS01395 Genome accession   NZ_OY769914
Coordinates   246152..247093 (+) Length   313 a.a.
NCBI ID   WP_038804053.1    Uniprot ID   -
Organism   Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 241152..252093
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U8955_RS01375 (SDENT7746_01395) tgt 241183..242325 (+) 1143 WP_038804056.1 tRNA guanosine(34) transglycosylase Tgt -
  U8955_RS01380 (SDENT7746_01400) - 242459..244276 (+) 1818 WP_038804055.1 acyltransferase family protein -
  U8955_RS01385 (SDENT7746_01405) nagA 244417..245568 (+) 1152 WP_038804054.1 N-acetylglucosamine-6-phosphate deacetylase -
  U8955_RS01390 (SDENT7746_01410) - 245717..246082 (+) 366 WP_000286399.1 DUF1033 family protein -
  U8955_RS01395 (SDENT7746_01415) comGA/cglA/cilD 246152..247093 (+) 942 WP_038804053.1 competence type IV pilus ATPase ComGA Machinery gene
  U8955_RS01400 (SDENT7746_01420) comGB/cglB 247041..248057 (+) 1017 WP_068981894.1 competence type IV pilus assembly protein ComGB Machinery gene
  U8955_RS01405 (SDENT7746_01425) comGC/cglC 248059..248382 (+) 324 WP_038804052.1 competence type IV pilus major pilin ComGC Machinery gene
  U8955_RS01410 (SDENT7746_01430) comGD/cglD 248345..248779 (+) 435 WP_038804051.1 competence type IV pilus minor pilin ComGD Machinery gene
  U8955_RS01415 (SDENT7746_01435) comGE/cglE 248742..249044 (+) 303 WP_265101009.1 competence type IV pilus minor pilin ComGE Machinery gene
  U8955_RS01420 (SDENT7746_01440) comGF/cglF 249007..249468 (+) 462 WP_038804049.1 competence type IV pilus minor pilin ComGF Machinery gene
  U8955_RS01425 (SDENT7746_01445) comGG 249446..249858 (+) 413 Protein_260 competence type IV pilus minor pilin ComGG -
  U8955_RS01430 (SDENT7746_01450) - 249891..250481 (+) 591 WP_038804047.1 class I SAM-dependent methyltransferase -
  U8955_RS01435 (SDENT7746_01455) comYH 250540..251493 (+) 954 WP_038804046.1 class I SAM-dependent methyltransferase Machinery gene

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35559.41 Da        Isoelectric Point: 5.1409

>NTDB_id=1161691 U8955_RS01395 WP_038804053.1 246152..247093(+) (comGA/cglA/cilD) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MVQEIAQKIIATAKEKKAQDIYFIPKEKSYELHMRIGDERCLVDSYEFDVLAAVISHFKFVAGMNVGEKRRSQLGSCDYQ
YDEKVSSLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDMNELGEQYRQRGLYLFAGPVGSGKTTLMHELAQSLFKGQQ
VMSIEDPVEIKQEDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVTEEELAVVLQGVCYQRLIGGGGIVDFANKDYQEHQPTSWNAQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=1161691 U8955_RS01395 WP_038804053.1 246152..247093(+) (comGA/cglA/cilD) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGGTTCAAGAAATTGCACAGAAAATTATTGCGACTGCGAAAGAAAAGAAGGCTCAGGATATCTATTTTATCCCCAAGGA
AAAGTCCTACGAGCTTCACATGCGGATTGGAGACGAACGGTGTCTAGTTGATTCCTATGAGTTTGATGTTTTAGCTGCTG
TGATTAGTCATTTCAAGTTTGTGGCTGGGATGAATGTAGGAGAAAAGCGTCGCAGTCAGCTGGGTTCTTGTGATTATCAG
TATGACGAAAAGGTTTCTTCACTGCGTTTGTCTACCGTGGGAGATTATCGGGGGCATGAGAGTTTGGTTATTCGTTTGTT
GCACGATGAGGAGCAGGACCTGCATTTCTGGTTTCAGGATATGAACGAACTGGGTGAGCAGTACAGGCAACGGGGACTCT
ATCTCTTTGCAGGTCCAGTCGGAAGTGGCAAGACGACGCTGATGCACGAATTAGCCCAGTCTCTCTTTAAGGGGCAACAA
GTTATGTCTATTGAAGATCCTGTCGAGATCAAGCAGGAAGACATGCTCCAGTTGCAGTTGAATGAAGCGATTGGCTTGAC
CTATGAAAATCTGATCAAACTGTCTCTACGTCATCGTCCTGACCTCTTGATTATCGGTGAAATTCGTGATAGTGAGACGG
CACGTGCAGTTGTCAGAGCCAGTTTGACAGGGGCGACAGTCTTTTCGACCATTCATGCCAAGAGTATCCGAGGTGTTTAT
GAACGCCTTCTGGAGTTGGGTGTGACGGAGGAGGAACTAGCAGTTGTCCTACAAGGTGTCTGCTATCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAACAAAGACTATCAAGAACATCAGCCAACCAGCTGGAATGCGCAGATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAAACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(8-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

90.096

100

0.901
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

88.498

100

0.885
  comGA/cglA/cilD Streptococcus pneumoniae D39

88.498

100

0.885
  comGA/cglA/cilD Streptococcus pneumoniae R6

88.498

100

0.885
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

88.498

100

0.885
  comYA Streptococcus gordonii str. Challis substr. CH1

79.677

99.042

0.789
  comYA Streptococcus mutans UA159

67.203

99.361

0.668
  comYA Streptococcus mutans UA140

67.203

99.361

0.668
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60.645

99.042

0.601
  comGA Lactococcus lactis subsp. cremoris KW2

54.487

99.681

0.543
  comGA Latilactobacillus sakei subsp. sakei 23K

44.444

83.387

0.371

Multiple sequence alignment