Detailed information NTG1132318

Bioinformatically predicted

Overview

• Name: comYC
• Type: Machinery gene
• Locus tag: H1W81_RS02065
• Genome accession: NZ_LR824002
• Coordinates: 381063..381389 (+)
• Length: 108 a.a.
• NCBI ID: WP_002946126.1
• Uniprot ID: A0A0E2Q1B3
• Organism: Streptococcus thermophilus isolate STH_CIRM_67
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 376063..386389

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W81_RS02050 (STHERMO_0422)	-	378700..379062 (+)	363	WP_011226630.1	DUF1033 family protein	-
H1W81_RS02055 (STHERMO_0423)	comGA/cglA/cilD	379143..380084 (+)	942	WP_180484814.1	competence type IV pilus ATPase ComGA	Machinery gene
H1W81_RS02060 (STHERMO_0424)	comYB	379966..381066 (+)	1101	WP_375708571.1	competence type IV pilus assembly protein ComGB	Machinery gene
H1W81_RS02065 (STHERMO_0425)	comYC	381063..381389 (+)	327	WP_002946126.1	competence type IV pilus major pilin ComGC	Machinery gene
H1W81_RS02070 (STHERMO_0426)	comYD	381349..381777 (+)	429	WP_011226626.1	competence type IV pilus minor pilin ComGD	Machinery gene
H1W81_RS02075 (STHERMO_0427)	comGE	381749..382042 (+)	294	WP_011226625.1	competence type IV pilus minor pilin ComGE	-
H1W81_RS02080 (STHERMO_0428)	comYF	382026..382463 (+)	438	WP_014608742.1	competence type IV pilus minor pilin ComGF	Machinery gene
H1W81_RS02085 (STHERMO_0429)	comGG	382441..382758 (+)	318	WP_011226623.1	competence type IV pilus minor pilin ComGG	-
H1W81_RS02090 (STHERMO_0430)	comYH	382803..383759 (+)	957	WP_011226622.1	class I SAM-dependent methyltransferase	Machinery gene
H1W81_RS02095 (STHERMO_0431)	-	383815..385008 (+)	1194	WP_022096898.1	acetate kinase	-
H1W81_RS02100 (STHERMO_0432)	-	385257..385454 (+)	198	WP_011681682.1	helix-turn-helix transcriptional regulator	-
H1W81_RS09365 (STHERMO_0434)	-	385697..386122 (+)	426	WP_041827107.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 108 a.a.
• Molecular weight: 11914.00 Da
• Isoelectric Point: 9.9219

>NTDB_id=1132318 H1W81_RS02065 WP_002946126.1 381063..381389(+) (comYC) [Streptococcus thermophilus isolate STH_CIRM_67]
MKLMLKKLNAVKLRAFTLIEMLVVLLIISILLLLFVPNLSKQKDSVKETGNAAVVKVVDSQAELYEMKNNKTASLAALVS
EGQITQKQADSYNDYYAKHGGESRSVAN

Nucleotide

• Length: 327 bp

>NTDB_id=1132318 H1W81_RS02065 WP_002946126.1 381063..381389(+) (comYC) [Streptococcus thermophilus isolate STH_CIRM_67]
ATGAAATTGATGTTAAAAAAATTGAATGCCGTTAAATTACGAGCCTTTACTCTGATTGAAATGCTAGTAGTACTTCTCAT
TATCAGTATTCTCCTTTTGCTCTTTGTTCCTAACTTAAGCAAGCAGAAGGATTCCGTTAAGGAAACTGGAAATGCGGCTG
TAGTCAAGGTCGTGGATTCTCAGGCAGAACTTTATGAAATGAAGAATAACAAGACAGCTAGCTTGGCAGCTCTTGTTTCA
GAAGGTCAAATTACGCAAAAACAGGCAGATTCATATAATGATTACTATGCGAAACATGGTGGTGAAAGCCGCTCAGTGGC
CAATTAG

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (14-34)

3D structure

• AlphaFold DB: A0A0E2Q1B3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYC	Streptococcus mutans UA140	69.231	96.296	0.667
comYC	Streptococcus mutans UA159	69.231	96.296	0.667
comYC	Streptococcus gordonii str. Challis substr. CH1	63.81	97.222	0.62
comGC/cglC	Streptococcus mitis SK321	62.264	98.148	0.611
comGC/cglC	Streptococcus mitis NCTC 12261	58.333	100	0.583
comGC/cglC	Streptococcus pneumoniae D39	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae R6	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae Rx1	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae TIGR4	58.491	98.148	0.574
comGC	Lactococcus lactis subsp. cremoris KW2	56.604	98.148	0.556
comYC	Streptococcus suis isolate S10	60.227	81.481	0.491
comGC	Staphylococcus aureus MW2	50	72.222	0.361
comGC	Staphylococcus aureus N315	50	72.222	0.361