Detailed information NTG1131608

Bioinformatically predicted

Overview

• Name: comYC
• Type: Machinery gene
• Locus tag: H1W91_RS08905
• Genome accession: NZ_LR822032
• Coordinates: 1708980..1709306 (-)
• Length: 108 a.a.
• NCBI ID: WP_002946126.1
• Uniprot ID: A0A0E2Q1B3
• Organism: Streptococcus thermophilus isolate STH_CIRM_1050
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1703980..1714306

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W91_RS10205 (STHERMO_1963)	-	1704247..1704672 (-)	426	WP_111679733.1	CPBP family intramembrane glutamic endopeptidase	-
H1W91_RS08870 (STHERMO_1965)	-	1704915..1705112 (-)	198	WP_002885716.1	helix-turn-helix transcriptional regulator	-
H1W91_RS08875 (STHERMO_1966)	-	1705361..1706554 (-)	1194	WP_014608740.1	acetate kinase	-
H1W91_RS08880 (STHERMO_1967)	comYH	1706610..1707566 (-)	957	WP_180477178.1	class I SAM-dependent methyltransferase	Machinery gene
H1W91_RS08885 (STHERMO_1968)	comGG	1707611..1707928 (-)	318	WP_180477179.1	competence type IV pilus minor pilin ComGG	-
H1W91_RS08890 (STHERMO_1969)	comYF	1707906..1708343 (-)	438	WP_082309153.1	competence type IV pilus minor pilin ComGF	Machinery gene
H1W91_RS08895 (STHERMO_1970)	comGE	1708327..1708620 (-)	294	WP_011226625.1	competence type IV pilus minor pilin ComGE	-
H1W91_RS08900 (STHERMO_1971)	comGD	1708592..1709020 (-)	429	WP_253269448.1	competence type IV pilus minor pilin ComGD	-
H1W91_RS08905 (STHERMO_1972)	comYC	1708980..1709306 (-)	327	WP_002946126.1	competence type IV pilus major pilin ComGC	Machinery gene
H1W91_RS08910 (STHERMO_1973)	comYB	1709303..1710403 (-)	1101	WP_120764773.1	competence type IV pilus assembly protein ComGB	Machinery gene
H1W91_RS08915 (STHERMO_1974)	comGA/cglA/cilD	1710285..1711226 (-)	942	WP_022096896.1	competence type IV pilus ATPase ComGA	Machinery gene
H1W91_RS08920 (STHERMO_1975)	-	1711307..1711669 (-)	363	WP_014608746.1	DUF1033 family protein	-

Sequence

Protein

• Length: 108 a.a.
• Molecular weight: 11914.00 Da
• Isoelectric Point: 9.9219

>NTDB_id=1131608 H1W91_RS08905 WP_002946126.1 1708980..1709306(-) (comYC) [Streptococcus thermophilus isolate STH_CIRM_1050]
MKLMLKKLNAVKLRAFTLIEMLVVLLIISILLLLFVPNLSKQKDSVKETGNAAVVKVVDSQAELYEMKNNKTASLAALVS
EGQITQKQADSYNDYYAKHGGESRSVAN

Nucleotide

• Length: 327 bp

>NTDB_id=1131608 H1W91_RS08905 WP_002946126.1 1708980..1709306(-) (comYC) [Streptococcus thermophilus isolate STH_CIRM_1050]
ATGAAATTGATGTTAAAAAAATTGAATGCCGTTAAATTACGAGCCTTTACTCTGATTGAAATGCTAGTCGTACTTCTCAT
TATCAGTATTCTCCTTTTGCTCTTTGTTCCTAACTTAAGCAAGCAGAAGGATTCCGTTAAGGAAACTGGAAATGCGGCTG
TAGTCAAGGTCGTGGATTCTCAGGCAGAACTTTATGAAATGAAGAATAACAAGACAGCTAGCTTGGCAGCTCTTGTTTCA
GAAGGTCAAATTACGCAAAAACAGGCAGATTCATACAATGATTACTATGCGAAACATGGTGGTGAAAGCCGCTCAGTGGC
CAATTAG

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (14-34)

3D structure

• AlphaFold DB: A0A0E2Q1B3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYC	Streptococcus mutans UA140	69.231	96.296	0.667
comYC	Streptococcus mutans UA159	69.231	96.296	0.667
comYC	Streptococcus gordonii str. Challis substr. CH1	63.81	97.222	0.62
comGC/cglC	Streptococcus mitis SK321	62.264	98.148	0.611
comGC/cglC	Streptococcus mitis NCTC 12261	58.333	100	0.583
comGC/cglC	Streptococcus pneumoniae D39	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae R6	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae Rx1	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae TIGR4	58.491	98.148	0.574
comGC	Lactococcus lactis subsp. cremoris KW2	56.604	98.148	0.556
comYC	Streptococcus suis isolate S10	60.227	81.481	0.491
comGC	Staphylococcus aureus MW2	50	72.222	0.361
comGC	Staphylococcus aureus N315	50	72.222	0.361