Detailed information NTG1131237

Bioinformatically predicted

Overview

• Name: comX
• Type: Regulator
• Locus tag: H1X08_RS09105
• Genome accession: NZ_LR822025
• Coordinates: 1779266..1779763 (-)
• Length: 165 a.a.
• NCBI ID: WP_002949220.1
• Uniprot ID: A0A0M4HKA9
• Organism: Streptococcus thermophilus isolate STH_CIRM_961
• Function: activation of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1774266..1784763

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1X08_RS09085 (STHERMO_2082)	-	1774311..1775915 (-)	1605	WP_179972535.1	CTP synthase	-
H1X08_RS09090 (STHERMO_2083)	rpoE	1776166..1776741 (-)	576	WP_179972534.1	DNA-directed RNA polymerase subunit delta	-
H1X08_RS09095 (STHERMO_2084)	tig	1776899..1778182 (-)	1284	WP_180482266.1	trigger factor	-
H1X08_RS09100 (STHERMO_2085)	-	1778324..1779166 (+)	843	WP_179972532.1	mechanosensitive ion channel family protein	-
H1X08_RS09105 (STHERMO_2086)	comX	1779266..1779763 (-)	498	WP_002949220.1	sigma factor	Regulator
H1X08_RS09110	tnpA	1780055..1780356 (-)	302	Protein_1759	IS200/IS605 family transposase	-
H1X08_RS09115 (STHERMO_2088)	-	1781167..1782404 (+)	1238	WP_232086981.1	ISL3 family transposase	-

Sequence

Protein

• Length: 165 a.a.
• Molecular weight: 20160.12 Da
• Isoelectric Point: 5.2073

>NTDB_id=1131237 H1X08_RS09105 WP_002949220.1 1779266..1779763(-) (comX) [Streptococcus thermophilus isolate STH_CIRM_961]
MEQEVFVKAYEKVRPIVLKAFRQYFIQLWDQADMEQEAMMTLYQLLKKFPDLEKDDDKLRRYFKTKFRNRLNDEVRRQES
VKRQANRQCYVEISDIAFCIPNKELDMVDRLAYDEQLNAFREQLSSEDSLKLDRLLGGECFRGRKKMIRELRFWMVDFDP
CNEED

Nucleotide

• Length: 498 bp

>NTDB_id=1131237 H1X08_RS09105 WP_002949220.1 1779266..1779763(-) (comX) [Streptococcus thermophilus isolate STH_CIRM_961]
ATGGAACAAGAAGTTTTTGTTAAGGCATATGAAAAGGTAAGGCCAATTGTACTTAAGGCTTTTAGGCAATACTTTATTCA
GCTTTGGGATCAAGCTGACATGGAGCAAGAGGCGATGATGACTTTGTATCAGCTTTTAAAAAAGTTTCCTGATTTAGAGA
AAGATGATGATAAGTTACGTCGTTACTTTAAAACTAAGTTTAGGAATCGACTTAATGATGAAGTGAGGCGGCAGGAGTCA
GTAAAACGTCAAGCTAATAGACAGTGCTATGTTGAAATTTCAGATATTGCCTTTTGTATTCCCAATAAGGAGCTAGATAT
GGTTGATAGACTTGCTTATGATGAACAGCTTAATGCTTTTCGTGAGCAGTTATCATCGGAAGATTCTCTTAAGTTGGATC
GATTGTTGGGTGGTGAATGCTTTAGGGGAAGGAAAAAGATGATACGAGAGTTAAGATTTTGGATGGTTGACTTTGATCCA
TGTAATGAAGAAGACTGA

Domains

Predicted by InterproScan.

• Sigma-70 region 2 (Sigma70_r2) (10-79)

3D structure

• AlphaFold DB: A0A0M4HKA9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX	Streptococcus thermophilus LMD-9	100	100	1
comX	Streptococcus thermophilus LMG 18311	100	100	1
comX/sigX	Streptococcus salivarius strain HSISS4	89.091	100	0.891
comX	Streptococcus salivarius SK126	88.485	100	0.885
comX	Streptococcus sobrinus strain NIDR 6715-7	41.975	98.182	0.412
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	41.667	94.545	0.394
comX/sigX	Streptococcus mutans UA159	41.026	94.545	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX	Streptococcus suis D9	40.523	92.727	0.376
comX/sigX	Streptococcus suis isolate S10	40.523	92.727	0.376
comX/sigX	Streptococcus suis P1/7	40.523	92.727	0.376