Detailed information NTG1131119

Bioinformatically predicted

Overview

• Name: comX
• Type: Regulator
• Locus tag: H0514_RS09340
• Genome accession: NZ_LR822020
• Coordinates: 1822710..1823207 (-)
• Length: 165 a.a.
• NCBI ID: WP_002949220.1
• Uniprot ID: A0A0M4HKA9
• Organism: Streptococcus thermophilus isolate STH_CIRM_956
• Function: activation of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1817710..1828207

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0514_RS09320 (STHERMO_2141)	-	1817755..1819359 (-)	1605	WP_179972535.1	CTP synthase	-
H0514_RS09325 (STHERMO_2142)	rpoE	1819610..1820185 (-)	576	WP_179972534.1	DNA-directed RNA polymerase subunit delta	-
H0514_RS09330 (STHERMO_2143)	tig	1820343..1821626 (-)	1284	WP_179973227.1	trigger factor	-
H0514_RS09335 (STHERMO_2144)	-	1821768..1822610 (+)	843	WP_179972532.1	mechanosensitive ion channel family protein	-
H0514_RS09340 (STHERMO_2145)	comX	1822710..1823207 (-)	498	WP_002949220.1	sigma factor	Regulator
H0514_RS09345	tnpA	1823499..1823800 (-)	302	Protein_1806	IS200/IS605 family transposase	-
H0514_RS09350 (STHERMO_2147)	-	1824611..1825848 (+)	1238	WP_232086298.1	ISL3 family transposase	-
H0514_RS10450 (STHERMO_2148)	-	1826026..1827275 (+)	1250	Protein_1808	ISL3 family transposase	-

Sequence

Protein

• Length: 165 a.a.
• Molecular weight: 20160.12 Da
• Isoelectric Point: 5.2073

>NTDB_id=1131119 H0514_RS09340 WP_002949220.1 1822710..1823207(-) (comX) [Streptococcus thermophilus isolate STH_CIRM_956]
MEQEVFVKAYEKVRPIVLKAFRQYFIQLWDQADMEQEAMMTLYQLLKKFPDLEKDDDKLRRYFKTKFRNRLNDEVRRQES
VKRQANRQCYVEISDIAFCIPNKELDMVDRLAYDEQLNAFREQLSSEDSLKLDRLLGGECFRGRKKMIRELRFWMVDFDP
CNEED

Nucleotide

• Length: 498 bp

>NTDB_id=1131119 H0514_RS09340 WP_002949220.1 1822710..1823207(-) (comX) [Streptococcus thermophilus isolate STH_CIRM_956]
ATGGAACAAGAAGTTTTTGTTAAGGCATATGAAAAGGTAAGGCCAATTGTACTTAAGGCTTTTAGGCAATACTTTATTCA
GCTTTGGGATCAAGCTGACATGGAGCAAGAGGCGATGATGACTTTGTATCAGCTTTTAAAAAAGTTTCCTGATTTAGAGA
AAGATGATGATAAGTTACGTCGTTACTTTAAAACTAAGTTTAGGAATCGACTTAATGATGAAGTGAGGCGGCAGGAGTCA
GTAAAACGTCAAGCTAATAGACAGTGCTATGTTGAAATTTCAGATATTGCCTTTTGTATTCCCAATAAGGAGCTAGATAT
GGTTGATAGACTTGCTTATGATGAACAGCTTAATGCTTTTCGTGAGCAGTTATCATCGGAAGATTCTCTTAAGTTGGATC
GATTGTTGGGTGGTGAATGCTTTAGGGGAAGGAAAAAGATGATACGAGAGTTAAGATTTTGGATGGTTGACTTTGATCCA
TGTAATGAAGAAGACTGA

Domains

Predicted by InterproScan.

• Sigma-70 region 2 (Sigma70_r2) (10-79)

3D structure

• AlphaFold DB: A0A0M4HKA9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX	Streptococcus thermophilus LMD-9	100	100	1
comX	Streptococcus thermophilus LMG 18311	100	100	1
comX/sigX	Streptococcus salivarius strain HSISS4	89.091	100	0.891
comX	Streptococcus salivarius SK126	88.485	100	0.885
comX	Streptococcus sobrinus strain NIDR 6715-7	41.975	98.182	0.412
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	41.667	94.545	0.394
comX/sigX	Streptococcus mutans UA159	41.026	94.545	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX	Streptococcus suis D9	40.523	92.727	0.376
comX/sigX	Streptococcus suis isolate S10	40.523	92.727	0.376
comX/sigX	Streptococcus suis P1/7	40.523	92.727	0.376