Detailed information NTG1130815

Bioinformatically predicted

Overview

• Name: comYC
• Type: Machinery gene
• Locus tag: H0502_RS09195
• Genome accession: NZ_LR822013
• Coordinates: 1783371..1783697 (+)
• Length: 108 a.a.
• NCBI ID: WP_002946126.1
• Uniprot ID: A0A0E2Q1B3
• Organism: Streptococcus thermophilus isolate STH_CIRM_32
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1778371..1788697

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0502_RS09180 (STHERMO_2045)	-	1781008..1781370 (+)	363	WP_014608746.1	DUF1033 family protein	-
H0502_RS09185 (STHERMO_2046)	comGA/cglA/cilD	1781451..1782392 (+)	942	WP_014608745.1	competence type IV pilus ATPase ComGA	Machinery gene
H0502_RS09190 (STHERMO_2047)	comYB	1782274..1783374 (+)	1101	WP_120764773.1	competence type IV pilus assembly protein ComGB	Machinery gene
H0502_RS09195 (STHERMO_2048)	comYC	1783371..1783697 (+)	327	WP_002946126.1	competence type IV pilus major pilin ComGC	Machinery gene
H0502_RS09200 (STHERMO_2049)	comGD	1783657..1784085 (+)	429	WP_253269448.1	competence type IV pilus minor pilin ComGD	-
H0502_RS09205 (STHERMO_2050)	comGE	1784057..1784350 (+)	294	WP_082309154.1	competence type IV pilus minor pilin ComGE	-
H0502_RS09210 (STHERMO_2051)	comYF	1784334..1784771 (+)	438	WP_082309153.1	competence type IV pilus minor pilin ComGF	Machinery gene
H0502_RS09215 (STHERMO_2052)	comGG	1784749..1785066 (+)	318	WP_082309152.1	competence type IV pilus minor pilin ComGG	-
H0502_RS09220 (STHERMO_2053)	comYH	1785111..1786067 (+)	957	WP_084831205.1	class I SAM-dependent methyltransferase	Machinery gene
H0502_RS09225 (STHERMO_2054)	-	1786123..1787316 (+)	1194	WP_179970807.1	acetate kinase	-
H0502_RS09230 (STHERMO_2055)	-	1787565..1787762 (+)	198	WP_014727723.1	helix-turn-helix transcriptional regulator	-
H0502_RS10225 (STHERMO_2056)	-	1787774..1788049 (+)	276	WP_232086463.1	CAAX protease	-
H0502_RS10230 (STHERMO_2057)	-	1788093..1788431 (+)	339	WP_232086462.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 108 a.a.
• Molecular weight: 11914.00 Da
• Isoelectric Point: 9.9219

>NTDB_id=1130815 H0502_RS09195 WP_002946126.1 1783371..1783697(+) (comYC) [Streptococcus thermophilus isolate STH_CIRM_32]
MKLMLKKLNAVKLRAFTLIEMLVVLLIISILLLLFVPNLSKQKDSVKETGNAAVVKVVDSQAELYEMKNNKTASLAALVS
EGQITQKQADSYNDYYAKHGGESRSVAN

Nucleotide

• Length: 327 bp

>NTDB_id=1130815 H0502_RS09195 WP_002946126.1 1783371..1783697(+) (comYC) [Streptococcus thermophilus isolate STH_CIRM_32]
ATGAAATTGATGTTAAAAAAATTGAATGCTGTTAAATTACGAGCCTTTACTCTGATTGAAATGCTAGTCGTACTTCTCAT
TATCAGTATTCTCCTTTTGCTCTTTGTTCCTAACTTAAGCAAGCAGAAGGATTCCGTTAAGGAAACTGGAAATGCGGCTG
TAGTCAAGGTCGTGGATTCTCAGGCAGAACTTTATGAAATGAAGAATAACAAGACAGCTAGCTTGGCAGCTCTTGTTTCA
GAAGGTCAAATTACGCAAAAACAGGCAGATTCATACAATGATTACTATGCGAAACATGGTGGTGAAAGCCGCTCAGTGGC
CAATTAG

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (14-34)

3D structure

• AlphaFold DB: A0A0E2Q1B3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYC	Streptococcus mutans UA140	69.231	96.296	0.667
comYC	Streptococcus mutans UA159	69.231	96.296	0.667
comYC	Streptococcus gordonii str. Challis substr. CH1	63.81	97.222	0.62
comGC/cglC	Streptococcus mitis SK321	62.264	98.148	0.611
comGC/cglC	Streptococcus mitis NCTC 12261	58.333	100	0.583
comGC/cglC	Streptococcus pneumoniae D39	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae R6	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae Rx1	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae TIGR4	58.491	98.148	0.574
comGC	Lactococcus lactis subsp. cremoris KW2	56.604	98.148	0.556
comYC	Streptococcus suis isolate S10	60.227	81.481	0.491
comGC	Staphylococcus aureus MW2	50	72.222	0.361
comGC	Staphylococcus aureus N315	50	72.222	0.361