Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   FGL12_RS09820 Genome accession   NZ_LR594041
Coordinates   2030659..2031618 (-) Length   319 a.a.
NCBI ID   WP_012130942.1    Uniprot ID   A8AZI0
Organism   Streptococcus gordonii strain NCTC9124     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 2025659..2036618
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL12_RS09780 (NCTC9124_01971) - 2025688..2026878 (-) 1191 WP_012130934.1 acetate kinase -
  FGL12_RS09785 (NCTC9124_01972) comYH 2026928..2027881 (-) 954 WP_012130935.1 class I SAM-dependent methyltransferase Machinery gene
  FGL12_RS09790 (NCTC9124_01973) comGG 2027912..2028343 (-) 432 WP_223341947.1 competence type IV pilus minor pilin ComGG -
  FGL12_RS09795 (NCTC9124_01974) comGF/cglF 2028324..2028713 (-) 390 WP_241974402.1 competence type IV pilus minor pilin ComGF Machinery gene
  FGL12_RS09800 (NCTC9124_01975) comGE/cglE 2028740..2029039 (-) 300 WP_138101351.1 competence type IV pilus minor pilin ComGE Machinery gene
  FGL12_RS09805 (NCTC9124_01976) comYD 2029011..2029439 (-) 429 WP_012130939.1 competence type IV pilus minor pilin ComGD Machinery gene
  FGL12_RS09810 (NCTC9124_01977) comYC 2029399..2029716 (-) 318 WP_012130940.1 competence type IV pilus major pilin ComGC Machinery gene
  FGL12_RS09815 (NCTC9124_01978) comYB 2029713..2030747 (-) 1035 WP_012130941.1 competence type IV pilus assembly protein ComGB Machinery gene
  FGL12_RS09820 (NCTC9124_01979) comYA 2030659..2031618 (-) 960 WP_012130942.1 competence type IV pilus ATPase ComGA Machinery gene
  FGL12_RS09825 (NCTC9124_01980) - 2031720..2032088 (-) 369 WP_012130943.1 DUF1033 family protein -
  FGL12_RS09830 (NCTC9124_01981) rpoC 2032339..2035986 (-) 3648 WP_138101354.1 DNA-directed RNA polymerase subunit beta' -

Sequence

Protein


Download         Length: 319 a.a.        Molecular weight: 36602.65 Da        Isoelectric Point: 5.4546

>NTDB_id=1127527 FGL12_RS09820 WP_012130942.1 2030659..2031618(-) (comYA) [Streptococcus gordonii strain NCTC9124]
MVQKIAQAIVRQAKEECAQDIYFVPKDDCYELYMRIGDERRFIQTYDFDQLAAVISHFKFLAGMNVGEKRRSQLGSCDYR
YDDKETSIRLSTVGDYRGYESLVIRLLHDEETELKFWFTHFPELREKFKDRGLYLFSGPVGSGKTTLMHQLAQLKFKGQQ
VMSIEDPVEIKQEDMLQLQLNETIGLTYESLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIPGVY
ERLLELGVSEEELKIVLQGICYQRLIGGGGVIDFASDNYQEHEPTVWNQQIDQLLAAGHIHPEQAEAEKIRNQQAKTSY

Nucleotide


Download         Length: 960 bp        

>NTDB_id=1127527 FGL12_RS09820 WP_012130942.1 2030659..2031618(-) (comYA) [Streptococcus gordonii strain NCTC9124]
ATGGTTCAAAAAATTGCCCAGGCGATTGTCCGGCAAGCTAAGGAAGAGTGTGCTCAGGATATTTATTTTGTACCCAAGGA
TGATTGTTATGAACTTTATATGCGGATTGGTGATGAGCGACGCTTTATACAAACTTATGATTTTGACCAGCTAGCCGCTG
TGATTAGTCATTTTAAATTTTTAGCTGGGATGAATGTAGGAGAAAAACGTCGCAGTCAGCTGGGGTCCTGTGATTATCGC
TATGATGATAAGGAAACGTCAATTCGTCTGTCGACAGTAGGCGATTATCGCGGTTATGAAAGTTTAGTTATTCGACTTCT
GCATGACGAAGAGACAGAATTGAAGTTTTGGTTTACTCATTTTCCTGAATTGAGAGAGAAGTTTAAGGACCGAGGACTGT
ATCTTTTTTCGGGACCAGTAGGGAGTGGTAAGACCACTCTCATGCATCAATTAGCTCAACTAAAATTTAAGGGTCAGCAG
GTTATGTCCATTGAAGATCCTGTTGAAATCAAGCAAGAGGATATGCTTCAGCTTCAGCTGAATGAAACGATTGGTCTGAC
TTATGAAAGTCTGATTAAGCTTTCCCTGCGTCACCGTCCGGACTTGCTCATCATTGGAGAAATTCGGGATAGTGAAACTG
CTAGAGCGGTGGTTCGAGCTAGCTTGACGGGAGCTACAGTTTTTTCAACGATTCATGCTAAAAGCATTCCTGGTGTTTAC
GAACGCTTATTGGAATTGGGTGTTAGCGAGGAGGAGTTGAAAATTGTTTTACAGGGTATTTGCTATCAACGCTTGATTGG
GGGAGGAGGTGTGATAGACTTTGCCAGCGACAACTACCAAGAACACGAGCCGACCGTCTGGAATCAGCAGATTGATCAGC
TTCTTGCAGCAGGACATATCCATCCTGAGCAAGCAGAAGCAGAAAAAATTAGGAACCAGCAAGCAAAAACAAGTTATTGA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A8AZI0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus gordonii str. Challis substr. CH1

100

100

1
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

78.387

97.179

0.762
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

78.065

97.179

0.759
  comGA/cglA/cilD Streptococcus pneumoniae D39

78.065

97.179

0.759
  comGA/cglA/cilD Streptococcus pneumoniae R6

78.065

97.179

0.759
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

78.065

97.179

0.759
  comYA Streptococcus mutans UA159

67.093

98.119

0.658
  comYA Streptococcus mutans UA140

67.093

98.119

0.658
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

65.705

97.806

0.643
  comGA Lactococcus lactis subsp. cremoris KW2

54.114

99.06

0.536

Multiple sequence alignment