Detailed information NTG1121386

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EL130_RS00610
• Genome accession: NZ_LR134320
• Coordinates: 111919..112671 (-)
• Length: 250 a.a.
• NCBI ID: WP_002277686.1
• Uniprot ID: A0A829BQB2
• Organism: Streptococcus mutans strain NCTC10832
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 106919..117671

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL130_RS00580 (NCTC10832_00106)	-	107468..107887 (-)	420	WP_002263913.1	hypothetical protein	-
EL130_RS00590 (NCTC10832_00107)	-	109267..109668 (-)	402	WP_002310604.1	hypothetical protein	-
EL130_RS00595 (NCTC10832_00108)	cipB	109799..110029 (-)	231	WP_002283381.1	Blp family class II bacteriocin	Regulator
EL130_RS00600 (NCTC10832_00109)	comC/blpC	110297..110428 (+)	132	WP_002273928.1	ComC/BlpC family leader-containing pheromone/bacteriocin	Regulator
EL130_RS00605 (NCTC10832_00110)	comD/blpH	110597..111922 (-)	1326	WP_002277687.1	sensor histidine kinase	Regulator
EL130_RS00610 (NCTC10832_00111)	comE/blpR	111919..112671 (-)	753	WP_002277686.1	response regulator transcription factor	Regulator
EL130_RS00615 (NCTC10832_00112)	-	113136..113774 (-)	639	WP_002262115.1	VTT domain-containing protein	-
EL130_RS00620 (NCTC10832_00113)	-	113822..114448 (-)	627	WP_002277685.1	hypothetical protein	-
EL130_RS00625 (NCTC10832_00114)	der	114523..115833 (-)	1311	WP_002277684.1	ribosome biogenesis GTPase Der	-
EL130_RS00630 (NCTC10832_00115)	dnaI	115846..116745 (-)	900	WP_002265120.1	primosomal protein DnaI	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29301.65 Da
• Isoelectric Point: 8.2551

>NTDB_id=1121386 EL130_RS00610 WP_002277686.1 111919..112671(-) (comE/blpR) [Streptococcus mutans strain NCTC10832]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDAIPEKGSHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIESALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMADIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide

• Length: 753 bp

>NTDB_id=1121386 EL130_RS00610 WP_002277686.1 111919..112671(-) (comE/blpR) [Streptococcus mutans strain NCTC10832]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAACAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGACGCTATCCCTGAAAAGGGCAGTC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCAGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATCAGCGCTGTATTATGCTATGGAAAACA
GCCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTTTATGGTAGTAT
GGCTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAGCGATTGGCTTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (153-242)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A829BQB2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	99.2	100	0.992
comE/comE1	Streptococcus equinus JB1	46.888	96.4	0.452
comE	Streptococcus infantis strain Atu-4	42.105	98.8	0.416
comE	Streptococcus mitis NCTC 12261	41.296	98.8	0.408
comE	Streptococcus pneumoniae Rx1	40.891	98.8	0.404
comE	Streptococcus mitis SK321	40.891	98.8	0.404
comE	Streptococcus pneumoniae D39	40.891	98.8	0.404
comE	Streptococcus pneumoniae R6	40.891	98.8	0.404
comE	Streptococcus pneumoniae TIGR4	40.891	98.8	0.404
comE/comE2	Streptococcus equinus JB1	40.664	96.4	0.392
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.959	98	0.372
comE/comE2	Streptococcus gordonii strain NCTC7865	37.959	98	0.372