Detailed information    

insolico Bioinformatically predicted

Overview


Name   comC/blpC   Type   Regulator
Locus tag   EL130_RS00600 Genome accession   NZ_LR134320
Coordinates   110297..110428 (+) Length   43 a.a.
NCBI ID   WP_002273928.1    Uniprot ID   Q1WC06
Organism   Streptococcus mutans strain NCTC10832     
Function   binding to ComD; induce autophosphorylation of ComD; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context


Location: 105297..115428
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL130_RS00550 (NCTC10832_00103) - 105361..105573 (-) 213 WP_002264173.1 Blp family class II bacteriocin -
  EL130_RS10370 - 105653..105784 (+) 132 WP_002285725.1 hypothetical protein -
  EL130_RS00560 (NCTC10832_00104) - 105978..106142 (-) 165 WP_002265308.1 hypothetical protein -
  EL130_RS10270 - 106582..106794 (+) 213 Protein_103 IS3 family transposase -
  EL130_RS00575 (NCTC10832_00105) - 106917..107321 (-) 405 WP_002263912.1 hypothetical protein -
  EL130_RS00580 (NCTC10832_00106) - 107468..107887 (-) 420 WP_002263913.1 hypothetical protein -
  EL130_RS00590 (NCTC10832_00107) - 109267..109668 (-) 402 WP_002310604.1 hypothetical protein -
  EL130_RS00595 (NCTC10832_00108) cipB 109799..110029 (-) 231 WP_002283381.1 Blp family class II bacteriocin Regulator
  EL130_RS00600 (NCTC10832_00109) comC/blpC 110297..110428 (+) 132 WP_002273928.1 ComC/BlpC family leader-containing pheromone/bacteriocin Regulator
  EL130_RS00605 (NCTC10832_00110) comD/blpH 110597..111922 (-) 1326 WP_002277687.1 sensor histidine kinase Regulator
  EL130_RS00610 (NCTC10832_00111) comE/blpR 111919..112671 (-) 753 WP_002277686.1 response regulator transcription factor Regulator
  EL130_RS00615 (NCTC10832_00112) - 113136..113774 (-) 639 WP_002262115.1 VTT domain-containing protein -
  EL130_RS00620 (NCTC10832_00113) - 113822..114448 (-) 627 WP_002277685.1 hypothetical protein -

Sequence


Protein


Download         Length: 43 a.a.        Molecular weight: 4912.68 Da        Isoelectric Point: 10.1937

>NTDB_id=1121384 EL130_RS00600 WP_002273928.1 110297..110428(+) (comC/blpC) [Streptococcus mutans strain NCTC10832]
MKKTLSLKNDFKEIKTDELEIIIGGSGSLSTFFRLFNRSFTQA

Nucleotide


Download         Length: 132 bp        

>NTDB_id=1121384 EL130_RS00600 WP_002273928.1 110297..110428(+) (comC/blpC) [Streptococcus mutans strain NCTC10832]
ATGAAAAAAACACTATCATTAAAAAATGACTTTAAAGAAATTAAAACTGATGAATTAGAGATTATCATTGGCGGAAGCGG
AAGCCTATCAACATTTTTCCGGCTGTTTAACAGAAGTTTTACACAAGCTTAG

Domains


Predicted by InterproScan.

(1-32)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB Q1WC06

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/blpC Streptococcus mutans UA159

100

100

1

  comC/comC1 Streptococcus pneumoniae R6

44.444

83.721

0.372

  comC/comC1 Streptococcus pneumoniae G54

44.444

83.721

0.372

  comC/comC1 Streptococcus pneumoniae D39

44.444

83.721

0.372

  comC/comC1 Streptococcus pneumoniae Rx1

44.444

83.721

0.372


Multiple sequence alignment