Detailed information    

insolico Bioinformatically predicted

Overview

Name   comX/comX2   Type   Regulator
Locus tag   A66_RS00105 Genome accession   NZ_LN847353
Coordinates   19738..20217 (+) Length   159 a.a.
NCBI ID   WP_000588897.1    Uniprot ID   Q9R2W8
Organism   Streptococcus pneumoniae strain A66     
Function   activate transcription of late competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 14738..25217
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A66_RS00090 (A66_00017) tilS 15819..17096 (+) 1278 WP_001208986.1 tRNA lysidine(34) synthetase TilS -
  A66_RS00095 (A66_00018) hpt 17100..17642 (+) 543 WP_000892185.1 hypoxanthine phosphoribosyltransferase -
  A66_RS00100 (A66_00019) ftsH 17658..19616 (+) 1959 WP_000744557.1 ATP-dependent zinc metalloprotease FtsH -
  A66_RS00105 (A66_00020) comX/comX2 19738..20217 (+) 480 WP_000588897.1 sigma-70 family RNA polymerase sigma factor Regulator
  A66_RS10485 (A66_00021) - 20307..20558 (+) 252 Protein_20 transposase -
  A66_RS10490 - 20593..21390 (-) 798 Protein_21 transposase -
  A66_RS00125 (A66_00025) comW 21656..21892 (+) 237 WP_000939545.1 sigma(X)-activator ComW Regulator
  A66_RS00130 (A66_00026) - 22123..23409 (+) 1287 WP_014931787.1 adenylosuccinate synthase -
  A66_RS00135 (A66_00027) tadA 23610..24077 (+) 468 WP_000291875.1 tRNA adenosine(34) deaminase TadA -
  A66_RS00140 (A66_00028) - 24264..24707 (+) 444 WP_000701992.1 dUTP diphosphatase -

Sequence

Protein


Download         Length: 159 a.a.        Molecular weight: 19873.52 Da        Isoelectric Point: 7.3797

>NTDB_id=1114547 A66_RS00105 WP_000588897.1 19738..20217(+) (comX/comX2) [Streptococcus pneumoniae strain A66]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISREEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH

Nucleotide


Download         Length: 480 bp        

>NTDB_id=1114547 A66_RS00105 WP_000588897.1 19738..20217(+) (comX/comX2) [Streptococcus pneumoniae strain A66]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTGTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGACCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGTAGACGATATTCCAC
GTTTAAGGAAATATTTCAAAACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAGCAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGTGAGATCAGTCATCGTATAAGTGAGGGGGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCATTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9R2W8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comX/comX2 Streptococcus pneumoniae Rx1

100

100

1
  comX/comX1 Streptococcus pneumoniae Rx1

100

100

1
  comX/comX2 Streptococcus pneumoniae D39

100

100

1
  comX/comX1 Streptococcus pneumoniae D39

100

100

1
  comX/comX2 Streptococcus pneumoniae R6

100

100

1
  comX/comX1 Streptococcus pneumoniae R6

100

100

1
  comX/comX2 Streptococcus pneumoniae TIGR4

99.371

100

0.994
  comX/comX1 Streptococcus pneumoniae TIGR4

99.371

100

0.994
  comX/sigX/comX1/sigX1 Streptococcus mitis NCTC 12261

92.453

100

0.925
  comX/sigX/comX2/sigX2 Streptococcus mitis NCTC 12261

92.453

100

0.925
  comX/sigX/comX2/sigX2 Streptococcus mitis SK321

90.566

100

0.906
  comX/sigX/comX1/sigX1 Streptococcus mitis SK321

89.241

99.371

0.887
  comR/comR2 Streptococcus gordonii str. Challis substr. CH1

48.718

98.113

0.478
  comR/comR1 Streptococcus gordonii str. Challis substr. CH1

48.718

98.113

0.478
  comX/sigX Streptococcus mutans UA159

46

94.34

0.434
  comX/sigX Streptococcus suis isolate S10

45.695

94.969

0.434
  comX/sigX Streptococcus suis D9

45.695

94.969

0.434
  comX/sigX Streptococcus suis P1/7

45.695

94.969

0.434
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS315

39.216

96.226

0.377
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS315

39.216

96.226

0.377
  comX/sigX/comX2/sigX2 Streptococcus pyogenes JRS4

40

94.34

0.377
  comX/sigX/comX1/sigX1 Streptococcus pyogenes JRS4

40

94.34

0.377
  comX/sigX/comX2/sigX2 Streptococcus pyogenes MGAS8232

40

94.34

0.377
  comX/sigX/comX1/sigX1 Streptococcus pyogenes MGAS8232

40

94.34

0.377

Multiple sequence alignment