Detailed information NTG1069067

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ACF1RT_RS01445
• Genome accession: NZ_CP172847
• Coordinates: 288605..289360 (+)
• Length: 251 a.a.
• NCBI ID: WP_226711110.1
• Uniprot ID: -
• Organism: Streptococcus mutans strain DPC6143
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 283605..294360

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACF1RT_RS01425 (ACF1RT_01425)	dnaI	284525..285424 (+)	900	WP_002267936.1	primosomal protein DnaI	-
ACF1RT_RS01430 (ACF1RT_01430)	der	285437..286747 (+)	1311	WP_226711107.1	ribosome biogenesis GTPase Der	-
ACF1RT_RS01435 (ACF1RT_01435)	-	286822..287448 (+)	627	WP_002268642.1	hypothetical protein	-
ACF1RT_RS01440 (ACF1RT_01440)	-	287496..288134 (+)	639	WP_002271525.1	VTT domain-containing protein	-
ACF1RT_RS01445 (ACF1RT_01445)	comE/blpR	288605..289360 (+)	756	WP_226711110.1	response regulator transcription factor	Regulator
ACF1RT_RS01450 (ACF1RT_01450)	comD/blpH	289353..290678 (+)	1326	WP_400260324.1	sensor histidine kinase	Regulator
ACF1RT_RS01455 (ACF1RT_01455)	comC/blpC	290820..290960 (-)	141	WP_002267610.1	ComC/BlpC family leader-containing pheromone/bacteriocin	Regulator
ACF1RT_RS01460 (ACF1RT_01460)	cipB	291227..291457 (+)	231	WP_002265368.1	Blp family class II bacteriocin	Regulator
ACF1RT_RS01465 (ACF1RT_01465)	-	291588..291989 (+)	402	WP_002310604.1	hypothetical protein	-
ACF1RT_RS01470 (ACF1RT_01470)	-	293370..293789 (+)	420	WP_002263913.1	hypothetical protein	-
ACF1RT_RS01475 (ACF1RT_01475)	-	293936..294340 (+)	405	WP_002263912.1	hypothetical protein	-

Sequence

Protein

• Length: 251 a.a.
• Molecular weight: 29502.83 Da
• Isoelectric Point: 7.4401

>NTDB_id=1069067 ACF1RT_RS01445 WP_226711110.1 288605..289360(+) (comE/blpR) [Streptococcus mutans strain DPC6143]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDAIPEKGSHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIELALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRTNE

Nucleotide

• Length: 756 bp

>NTDB_id=1069067 ACF1RT_RS01445 WP_226711110.1 288605..289360(+) (comE/blpR) [Streptococcus mutans strain DPC6143]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAACAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGACGCTATCCCTGAAAAGGGCAGTC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCGGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATTAGCGCTGTATTATGCTATGGAAAACA
GTCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTCTACGGCAGTAT
GACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAACGCTTGGCCTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAACAAATGAATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (153-242)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	98.795	99.203	0.98
comE/comE1	Streptococcus equinus JB1	46.888	96.016	0.45
comE	Streptococcus mitis NCTC 12261	41.7	98.406	0.41
comE	Streptococcus infantis strain Atu-4	41.7	98.406	0.41
comE	Streptococcus pneumoniae D39	41.296	98.406	0.406
comE	Streptococcus pneumoniae Rx1	41.296	98.406	0.406
comE	Streptococcus pneumoniae R6	41.296	98.406	0.406
comE	Streptococcus pneumoniae TIGR4	41.296	98.406	0.406
comE	Streptococcus mitis SK321	41.296	98.406	0.406
comE/comE2	Streptococcus equinus JB1	40.664	96.016	0.39
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	36.759	100	0.371
comE/comE2	Streptococcus gordonii strain NCTC7865	36.759	100	0.371