Detailed information NTG0099150

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SP4011_RS11370
• Genome accession: NZ_AP026968
• Coordinates: 2321737..2322489 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus parapneumoniae strain SP4011
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2316737..2327489

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP4011_RS11350 (SP4011_21950)	-	2318182..2320824 (-)	2643	WP_338619372.1	YhgE/Pip domain-containing protein	-
SP4011_RS11355 (SP4011_21960)	-	2320952..2321494 (+)	543	WP_338619373.1	TetR/AcrR family transcriptional regulator	-
SP4011_RS11370 (SP4011_21970)	comE	2321737..2322489 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SP4011_RS11375 (SP4011_21980)	comD/comD1	2322486..2323811 (-)	1326	WP_218757900.1	GHKL domain-containing protein	Regulator
SP4011_RS11380 (SP4011_21990)	comC/comC1	2323832..2323957 (-)	126	WP_218757899.1	competence-stimulating peptide ComC	Regulator
SP4011_RS11390 (SP4011_22000)	rlmH	2324240..2324719 (-)	480	WP_084367488.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SP4011_RS11395 (SP4011_22010)	htrA	2324903..2326084 (+)	1182	WP_338619378.1	S1C family serine protease	Regulator
SP4011_RS11400 (SP4011_22020)	spo0J	2326142..2326900 (+)	759	WP_338619379.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=99150 SP4011_RS11370 WP_000866065.1 2321737..2322489(-) (comE) [Streptococcus parapneumoniae strain SP4011]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=99150 SP4011_RS11370 WP_000866065.1 2321737..2322489(-) (comE) [Streptococcus parapneumoniae strain SP4011]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAGTC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATATATTGAAAACGATGAAGTAAACCAGC
TTTATTTCCTAGATATCGATATTCATGGGATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCTTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACTAAAAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTATAATTACAAGGGAAATGATTTAAAAATTCCTTATCATGACATTCTGTAT
ATTGAAACGACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTCTATGGAACAATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGGTTAAAAATTAGAAAATTG
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408