Detailed information NTG0099153

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SP4011_RS11395
• Genome accession: NZ_AP026968
• Coordinates: 2324903..2326084 (+)
• Length: 393 a.a.
• NCBI ID: WP_338619378.1
• Uniprot ID: -
• Organism: Streptococcus parapneumoniae strain SP4011
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2319903..2331084

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP4011_RS11355 (SP4011_21960)	-	2320952..2321494 (+)	543	WP_338619373.1	TetR/AcrR family transcriptional regulator	-
SP4011_RS11370 (SP4011_21970)	comE	2321737..2322489 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SP4011_RS11375 (SP4011_21980)	comD/comD1	2322486..2323811 (-)	1326	WP_218757900.1	GHKL domain-containing protein	Regulator
SP4011_RS11380 (SP4011_21990)	comC/comC1	2323832..2323957 (-)	126	WP_218757899.1	competence-stimulating peptide ComC	Regulator
SP4011_RS11390 (SP4011_22000)	rlmH	2324240..2324719 (-)	480	WP_084367488.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SP4011_RS11395 (SP4011_22010)	htrA	2324903..2326084 (+)	1182	WP_338619378.1	S1C family serine protease	Regulator
SP4011_RS11400 (SP4011_22020)	spo0J	2326142..2326900 (+)	759	WP_338619379.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41615.43 Da
• Isoelectric Point: 6.1498

>NTDB_id=99153 SP4011_RS11395 WP_338619378.1 2324903..2326084(+) (htrA) [Streptococcus parapneumoniae strain SP4011]
MKHLKTFYKKGFQLLVVIVISFFSGALGSFSIAQLTQKSSVSNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDETDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNISTSDIRRLNIPSSVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=99153 SP4011_RS11395 WP_338619378.1 2324903..2326084(+) (htrA) [Streptococcus parapneumoniae strain SP4011]
ATGAAACATTTAAAAACATTTTACAAAAAAGGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAGCTCAACTAACTCAAAAAAGTAGTGTAAGCAACTCTAACAACAATAGCACTATTACACAGACTG
CCTATAAAAACGAAAATTCAACCACTCAGGCTGTTAATAAAGTAAAAGATGCTGTTGTATCCGTTATTACTTATTCAGCA
AATAGACAAAATAGCGTATTTGGCAATGATGAGACTGATACAGATTCTCAGCAAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGACAAAGAGGCTTACATTGTCACCAATAATCACGTTATAAATGGTGCCAGTAAAGTAGATATTCGCT
TATCAGATGGAACTAAAGTACCCGGAGAAATTGTCGGAGCGGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAATTTGGTGATTCTAGTAAGTTAACCGTAGGAGAAACTGCTATTGCTATTGGTAGCCC
GCTCGGTTCTGAATATGCTAATACTGTCACTCAAGGTATCGTATCTAGTCTCAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGTCCACTGATCAAT
ATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGCACATCTGTAGAAGGGCTTGGTTTCGC
AATCCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAGAACGGAAAAGTGACACGCCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATATAAGTACAAGCGACATCAGAAGACTCAATATTCCAAGCAGTGTAACATCTGGCGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTCATTACAAAAGTAGACGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACTATTAAGATAACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATCAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (289-384)

• Peptidase family M50 (Peptidase_M50) (236-388)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	98.219	100	0.982
htrA	Streptococcus pneumoniae Rx1	97.71	100	0.977
htrA	Streptococcus pneumoniae D39	97.71	100	0.977
htrA	Streptococcus pneumoniae R6	97.71	100	0.977
htrA	Streptococcus pneumoniae TIGR4	97.71	100	0.977
htrA	Streptococcus gordonii str. Challis substr. CH1	66.414	100	0.669
htrA	Streptococcus mutans UA159	54.822	100	0.55