Detailed information NTG0097615

Bioinformatically predicted

Overview

• Name: comX/comX2
• Type: Regulator
• Locus tag: R8522_RS00170
• Genome accession: NZ_AP026916
• Coordinates: 28554..29033 (+)
• Length: 159 a.a.
• NCBI ID: WP_000588897.1
• Uniprot ID: Q9R2W8
• Organism: Streptococcus pneumoniae strain PZ900700006
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	27004..28330	28554..29033	flank	224

Gene organization within MGE regions

Location: 27004..29033

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8522_RS00165	-	27004..28330 (-)	1327	Protein_33	ISL3 family transposase	-
R8522_RS00170 (PC0006_00380)	comX/comX2	28554..29033 (+)	480	WP_000588897.1	sigma-70 family RNA polymerase sigma factor	Regulator

Sequence

Protein

• Length: 159 a.a.
• Molecular weight: 19873.52 Da
• Isoelectric Point: 7.3797

>NTDB_id=97615 R8522_RS00170 WP_000588897.1 28554..29033(+) (comX/comX2) [Streptococcus pneumoniae strain PZ900700006]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISREEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH

Nucleotide

• Length: 480 bp

>NTDB_id=97615 R8522_RS00170 WP_000588897.1 28554..29033(+) (comX/comX2) [Streptococcus pneumoniae strain PZ900700006]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTGTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGACCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGTAGACGATATTCCAC
GTTTAAGGAAATATTTCAAAACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAGCAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGTGAGATCAGTCATCGTATAAGTGAGGGGGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCACTAG

Domains

No domain identified.

3D structure

• AlphaFold DB: Q9R2W8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/comX2	Streptococcus pneumoniae Rx1	100	100	1
comX/comX1	Streptococcus pneumoniae Rx1	100	100	1
comX/comX2	Streptococcus pneumoniae D39	100	100	1
comX/comX1	Streptococcus pneumoniae D39	100	100	1
comX/comX2	Streptococcus pneumoniae R6	100	100	1
comX/comX1	Streptococcus pneumoniae R6	100	100	1
comX/comX2	Streptococcus pneumoniae TIGR4	99.371	100	0.994
comX/comX1	Streptococcus pneumoniae TIGR4	99.371	100	0.994
comX/sigX/comX1/sigX1	Streptococcus mitis NCTC 12261	92.453	100	0.925
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	92.453	100	0.925
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	90.566	100	0.906
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	89.241	99.371	0.887
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comX/sigX	Streptococcus mutans UA159	46	94.34	0.434
comX/sigX	Streptococcus suis isolate S10	45.695	94.969	0.434
comX/sigX	Streptococcus suis D9	45.695	94.969	0.434
comX/sigX	Streptococcus suis P1/7	45.695	94.969	0.434
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	40	94.34	0.377