Detailed information NTG0964644

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: NYE79_RS09970
• Genome accession: NZ_CP150168
• Coordinates: 2043007..2043759 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866079.1
• Uniprot ID: A0A081R422
• Organism: Streptococcus sp. FSL W8-0197
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2038007..2048759

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NYE79_RS09950 (NYE79_09950)	-	2039444..2042098 (-)	2655	WP_000472068.1	YhgE/Pip domain-containing protein	-
NYE79_RS09955 (NYE79_09955)	-	2042227..2042769 (+)	543	WP_000665080.1	TetR-like C-terminal domain-containing protein	-
NYE79_RS09970 (NYE79_09970)	comE	2043007..2043759 (-)	753	WP_000866079.1	competence system response regulator transcription factor ComE	Regulator
NYE79_RS09975 (NYE79_09975)	comD	2043756..2045075 (-)	1320	WP_000362886.1	competence system sensor histidine kinase ComD	Regulator
NYE79_RS09980 (NYE79_09980)	comC/comC2	2045096..2045221 (-)	126	WP_000799678.1	competence-stimulating peptide ComC	Regulator
NYE79_RS09990 (NYE79_09990)	rlmH	2045503..2045982 (-)	480	WP_000694219.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
NYE79_RS09995 (NYE79_09995)	htrA	2046168..2047364 (+)	1197	WP_084877132.1	S1C family serine protease	Regulator
NYE79_RS10000 (NYE79_10000)	spo0J	2047422..2048180 (+)	759	WP_216728672.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29884.23 Da
• Isoelectric Point: 6.9755

>NTDB_id=964644 NYE79_RS09970 WP_000866079.1 2043007..2043759(-) (comE) [Streptococcus sp. FSL W8-0197]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=964644 NYE79_RS09970 WP_000866079.1 2043007..2043759(-) (comE) [Streptococcus sp. FSL W8-0197]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTAAATGAAATCTCGGAAGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATCGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAGTTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACTTACAAATACCAGGTATCAGCTCTAGATTT
TGTAGACAAAGACATCAATGATGAATTGTTCAAAAAACGTATCGAGCAGAGTATTTTTTACACTAAGAGTATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAGGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCTAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGCCCGATTACCCGTTTGAAAGTTCGCAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081R422

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.6	100	0.956
comE	Streptococcus mitis SK321	94.8	100	0.948
comE	Streptococcus pneumoniae Rx1	94	100	0.94
comE	Streptococcus pneumoniae D39	94	100	0.94
comE	Streptococcus pneumoniae R6	94	100	0.94
comE	Streptococcus pneumoniae TIGR4	94	100	0.94
comE	Streptococcus infantis strain Atu-4	93.6	100	0.936
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4