Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   NYE79_RS09995 Genome accession   NZ_CP150168
Coordinates   2046168..2047364 (+) Length   398 a.a.
NCBI ID   WP_084877132.1    Uniprot ID   A0A1X1H8B2
Organism   Streptococcus sp. FSL W8-0197     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2041168..2052364
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NYE79_RS09955 (NYE79_09955) - 2042227..2042769 (+) 543 WP_000665080.1 TetR-like C-terminal domain-containing protein -
  NYE79_RS09970 (NYE79_09970) comE 2043007..2043759 (-) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  NYE79_RS09975 (NYE79_09975) comD 2043756..2045075 (-) 1320 WP_000362886.1 competence system sensor histidine kinase ComD Regulator
  NYE79_RS09980 (NYE79_09980) comC/comC2 2045096..2045221 (-) 126 WP_000799678.1 competence-stimulating peptide ComC Regulator
  NYE79_RS09990 (NYE79_09990) rlmH 2045503..2045982 (-) 480 WP_000694219.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  NYE79_RS09995 (NYE79_09995) htrA 2046168..2047364 (+) 1197 WP_084877132.1 S1C family serine protease Regulator
  NYE79_RS10000 (NYE79_10000) spo0J 2047422..2048180 (+) 759 WP_216728672.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 398 a.a.        Molecular weight: 42027.84 Da        Isoelectric Point: 6.6578

>NTDB_id=964647 NYE79_RS09995 WP_084877132.1 2046168..2047364(+) (htrA) [Streptococcus sp. FSL W8-0197]
MKHLQKFYKKGVKVLIIILIGFLSGALGSFVTLQLYQKQGNQATNNNSGTVTQTSYKNENSTTQAVNKVKDAVVSIITYS
SSSSRQSSVFNADDTNSDSDNQQIASEGSGVIYKKDDKDAYLVTNTHVINGASKVDIRLADGTKVPGEIVGSDTFSDIAV
VKISSEKVTTVAEFGDSSQLSVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSG
GPLVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESNGKVTRPALGIQMVNLSNVGASDLRKLNIPSGL
TSGVVVRSVQNNMPANGHLQKYDVITKVDDKEIASSTDLQHALYNHAIGDTIKVTYYRNGKEETTSIKLDKNSSDLES

Nucleotide


Download         Length: 1197 bp        

>NTDB_id=964647 NYE79_RS09995 WP_084877132.1 2046168..2047364(+) (htrA) [Streptococcus sp. FSL W8-0197]
ATGAAACACTTACAAAAATTTTACAAAAAAGGAGTTAAAGTTCTAATAATCATTCTAATCGGATTTTTAAGTGGTGCCTT
AGGAAGTTTCGTAACATTACAACTTTATCAAAAACAAGGAAATCAAGCTACAAATAATAATTCTGGCACTGTCACTCAAA
CATCCTATAAGAATGAAAATTCAACCACTCAAGCAGTAAATAAAGTTAAGGATGCTGTTGTCTCAATCATTACTTATTCT
TCTTCTAGTAGTAGACAAAGTAGTGTATTTAATGCTGATGACACTAACTCTGATTCAGACAATCAACAAATCGCAAGTGA
GGGATCAGGTGTCATCTATAAAAAGGATGATAAAGATGCCTATCTTGTAACCAATACTCACGTTATCAATGGAGCTTCAA
AAGTTGATATTCGCTTGGCAGATGGTACCAAGGTTCCTGGTGAAATTGTCGGATCTGATACTTTTTCTGATATTGCTGTC
GTTAAAATTTCTTCAGAAAAAGTTACAACAGTAGCAGAATTTGGGGATTCAAGTCAACTAAGTGTTGGAGAAACAGCGAT
TGCTATCGGTAGTCCTTTAGGTTCAGAATATGCTAATACAGTTACACAGGGGATTATTTCAAGTCTTAATCGAAATGTTT
CTCTAAAATCTGAAGATGGTCAAGCTATTTCAACAAAAGCCATTCAAACAGATACAGCCATTAACCCTGGTAACTCTGGT
GGTCCACTTGTAAACATTCAAGGACAAGTAATTGGTATTACATCAAGTAAAATTGCAAGTAATGGTGGTACATCTGTAGA
AGGTCTTGGTTTTGCAATTCCTTCAAACGATGCACAAAATATCATTAAACAGCTTGAAAGTAATGGTAAAGTGACTCGTC
CAGCTCTTGGAATTCAAATGGTCAATCTGTCAAATGTTGGAGCTAGTGATCTTAGAAAACTTAACATTCCAAGTGGCCTC
ACTTCAGGTGTAGTTGTTCGATCTGTTCAAAACAATATGCCAGCAAATGGACATCTTCAAAAATACGATGTCATTACCAA
AGTTGACGATAAAGAGATTGCTTCATCAACAGACCTACAACACGCTCTTTACAATCATGCTATTGGAGATACTATCAAAG
TAACCTACTACCGTAATGGTAAGGAGGAAACAACCTCAATTAAACTAGATAAGAATTCTAGTGATTTAGAGTCTTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(218-393)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

PDZ domain (PDZ_2)

(294-389)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1X1H8B2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

83.668

100

0.837
  htrA Streptococcus pneumoniae Rx1

82.915

100

0.829
  htrA Streptococcus pneumoniae D39

82.915

100

0.829
  htrA Streptococcus pneumoniae R6

82.915

100

0.829
  htrA Streptococcus pneumoniae TIGR4

82.915

100

0.829
  htrA Streptococcus gordonii str. Challis substr. CH1

67.164

100

0.678
  htrA Streptococcus mutans UA159

54.822

98.995

0.543

Multiple sequence alignment