Detailed information NTG0888988

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: F6I35_RS10710
• Genome accession: NZ_CP136160
• Coordinates: 2027664..2028413 (-)
• Length: 249 a.a.
• NCBI ID: WP_024052478.1
• Uniprot ID: A0A412PLH3
• Organism: Streptococcus anginosus strain UMB8616
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2022664..2033413

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
F6I35_RS10690 (F6I35_0010685)	-	2023051..2024673 (+)	1623	WP_070815056.1	ABC-F family ATP-binding cassette domain-containing protein	-
F6I35_RS10695 (F6I35_0010690)	-	2024740..2027316 (+)	2577	WP_024052479.1	YfhO family protein	-
F6I35_RS10710 (F6I35_0010705)	comE	2027664..2028413 (-)	750	WP_024052478.1	competence system response regulator transcription factor ComE	Regulator
F6I35_RS10715 (F6I35_0010710)	comD/comD2	2028413..2029735 (-)	1323	WP_371317911.1	sensor histidine kinase	Regulator
F6I35_RS10720 (F6I35_0010715)	-	2029756..2029902 (-)	147	WP_003029519.1	bacteriocin	-
F6I35_RS10730 (F6I35_0010725)	rlmH	2030184..2030663 (-)	480	WP_024052476.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
F6I35_RS10735 (F6I35_0010730)	htrA	2030857..2032047 (+)	1191	WP_024052475.1	S1C family serine protease	Regulator
F6I35_RS10740 (F6I35_0010735)	spo0J	2032102..2032869 (+)	768	WP_070672281.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29243.90 Da
• Isoelectric Point: 8.6042

>NTDB_id=888988 F6I35_RS10710 WP_024052478.1 2027664..2028413(-) (comE) [Streptococcus anginosus strain UMB8616]
MKVLVLEDEITHQVRMETTLAEIAKEMGITIKVKVTGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLSDVAFKKHIKDSIEYTKATLIENKDMVDYFEYNFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKETRRFFSPHKSYLVNIGNIKGYDKKMREIIFYEDHRCPITRMKIGKL
KAILEELKG

Nucleotide

• Length: 750 bp

>NTDB_id=888988 F6I35_RS10710 WP_024052478.1 2027664..2028413(-) (comE) [Streptococcus anginosus strain UMB8616]
ATGAAAGTATTAGTATTAGAAGATGAAATTACACATCAAGTAAGAATGGAAACAACTTTGGCAGAGATTGCAAAAGAAAT
GGGAATTACGATAAAAGTTAAAGTAACTGGAAAAGTAAGGGAATTTAAAGAATATATTGAAAACGATGAAGTAAATCAAT
TATATTTTTTAGATATTGATATCAAAGGAGAGGAAACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCACAATCCG
TATGCCATTATTGTTTTTGTTACAACGAAATCAGAATTTGCCACTATGACCTTCAAATATAAGGTATCTGCACTGGATTT
TGTTGACAAAAATTTGAGTGATGTTGCTTTTAAAAAACATATAAAAGACAGCATTGAGTATACAAAAGCGACATTGATTG
AAAATAAAGATATGGTGGATTATTTTGAATATAACTTTCGTGGCGGAGAGGTTAGAATGCCTTTTAATGACATTTTATAT
ATTGAAACGACAGGCTCTTCTCATAAATTAAGAATTGTCGGTAAAAACTTTTTTAAAGAATTCTATGGCACTATTGCAGA
TATTCAAGAAAAAGATAAAGAAACAAGACGTTTCTTTTCACCTCATAAATCCTACCTAGTCAATATTGGAAACATCAAAG
GTTATGACAAAAAAATGCGAGAAATAATTTTTTATGAAGATCATCGTTGTCCGATTACTCGAATGAAAATTGGAAAATTA
AAAGCTATTTTAGAGGAATTAAAAGGATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: A0A412PLH3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.02	98.394	0.699
comE	Streptococcus mitis SK321	70.204	98.394	0.691
comE	Streptococcus infantis strain Atu-4	70.204	98.394	0.691
comE	Streptococcus pneumoniae Rx1	69.796	98.394	0.687
comE	Streptococcus pneumoniae D39	69.796	98.394	0.687
comE	Streptococcus pneumoniae R6	69.796	98.394	0.687
comE	Streptococcus pneumoniae TIGR4	69.796	98.394	0.687
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	70.082	97.992	0.687
comE/comE2	Streptococcus gordonii strain NCTC7865	70.082	97.992	0.687
comE/blpR	Streptococcus mutans UA159	40.486	99.197	0.402
comE/comE2	Streptococcus equinus JB1	34.749	100	0.361