Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   V6U66_RS08960 Genome accession   NZ_CP145864
Coordinates   1921737..1922477 (+) Length   246 a.a.
NCBI ID   WP_164332023.1    Uniprot ID   -
Organism   Streptococcus salivarius strain KSS7     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1916737..1927477
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  V6U66_RS08930 (V6U66_08920) - 1917878..1918174 (-) 297 WP_155213959.1 bacteriocin immunity protein -
  V6U66_RS08935 (V6U66_08925) - 1918339..1919265 (-) 927 WP_175062649.1 thioredoxin family protein -
  V6U66_RS08940 (V6U66_08930) - 1919452..1919631 (-) 180 WP_155213961.1 bacteriocin transporter -
  V6U66_RS08945 (V6U66_08935) - 1919660..1920052 (-) 393 WP_003094909.1 hypothetical protein -
  V6U66_RS08950 (V6U66_08940) cipB 1920064..1920303 (-) 240 WP_021152514.1 Blp family class II bacteriocin Regulator
  V6U66_RS08955 (V6U66_08945) - 1920889..1921143 (-) 255 WP_021152515.1 Blp family class II bacteriocin -
  V6U66_RS08960 (V6U66_08950) comE/blpR 1921737..1922477 (+) 741 WP_164332023.1 LytR/AlgR family response regulator transcription factor Regulator
  V6U66_RS08965 (V6U66_08955) - 1922792..1923808 (+) 1017 WP_339313535.1 sensor histidine kinase -
  V6U66_RS08970 (V6U66_08960) - 1923836..1923991 (-) 156 WP_021152520.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  V6U66_RS08975 (V6U66_08965) comB 1924008..1925231 (-) 1224 WP_049527520.1 HlyD family efflux transporter periplasmic adaptor subunit Regulator
  V6U66_RS08980 (V6U66_08970) comA/nlmT 1925243..1927399 (-) 2157 WP_107372339.1 peptide cleavage/export ABC transporter Regulator

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 28712.37 Da        Isoelectric Point: 9.4043

>NTDB_id=853646 V6U66_RS08960 WP_164332023.1 1921737..1922477(+) (comE/blpR) [Streptococcus salivarius strain KSS7]
MDIYILEDNLIQQGRLERVLSQELKKYNKDLSIVHTFDKPKQLIEAFESTTSNQLFFLDIEIKGEKLKGLDIAKIIREKN
PYATIIFVTTHSEFMPLVFDYQVSALDYIDKSLSEIEFRKKITRALAITMKPLGIENDEIFDFQTQHTAIRIPLNQVIYI
ETSPQKHYVILHGTNNQMTFRANLKDLEKASPSLVSCHRSYLINPKNILRINKLKREVEMTDGSICPFSRTKAKMLIDTF
KRRNLQ

Nucleotide


Download         Length: 741 bp        

>NTDB_id=853646 V6U66_RS08960 WP_164332023.1 1921737..1922477(+) (comE/blpR) [Streptococcus salivarius strain KSS7]
TTGGATATATATATCTTAGAGGACAATCTCATTCAACAAGGAAGACTGGAGAGGGTATTGTCTCAAGAGTTAAAAAAATA
CAACAAAGACTTATCTATTGTCCACACGTTTGATAAGCCTAAGCAACTTATAGAAGCGTTTGAGTCAACAACTTCTAACC
AGCTCTTTTTTCTTGATATCGAAATTAAAGGAGAAAAATTAAAAGGGCTTGATATTGCTAAAATCATTAGGGAAAAAAAC
CCCTATGCTACTATTATCTTTGTCACTACTCACTCAGAGTTCATGCCACTAGTTTTTGATTACCAAGTATCTGCCCTAGA
CTATATCGACAAAAGTCTCTCTGAAATAGAATTTAGGAAAAAGATAACCAGAGCTTTAGCTATAACTATGAAACCACTTG
GAATAGAGAATGACGAGATTTTTGATTTTCAAACACAACATACAGCTATTCGCATCCCTTTAAACCAAGTTATTTATATT
GAAACTTCTCCTCAAAAGCATTATGTAATACTTCATGGTACAAACAACCAAATGACCTTTCGTGCAAATCTAAAGGATCT
TGAAAAAGCTAGTCCTTCACTCGTATCTTGCCATCGTTCGTATCTCATTAATCCTAAAAACATTTTAAGAATCAACAAAT
TAAAACGTGAAGTCGAAATGACTGATGGTAGTATCTGTCCTTTTTCACGTACCAAAGCTAAAATGCTGATAGATACTTTT
AAAAGAAGGAACCTTCAATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-122)

LytTr DNA-binding domain (LytTR)

(150-237)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

43.162

95.122

0.411
  comE/comE2 Streptococcus equinus JB1

39.662

96.341

0.382
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.2

100

0.378
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.2

100

0.378
  comE/comE1 Streptococcus equinus JB1

38.235

96.748

0.37
  comE Streptococcus pneumoniae D39

35.6

100

0.362
  comE Streptococcus pneumoniae R6

35.6

100

0.362
  comE Streptococcus pneumoniae TIGR4

35.6

100

0.362
  comE Streptococcus mitis SK321

35.6

100

0.362
  comE Streptococcus mitis NCTC 12261

35.6

100

0.362
  comE Streptococcus pneumoniae Rx1

35.6

100

0.362
  comE Streptococcus infantis strain Atu-4

35.6

100

0.362