Detailed information
Bioinformatically predicted
Overview
| Name | comE/blpR | Type | Regulator |
| Locus tag | H7680_RS02570 | Genome accession | NZ_AP023394 |
| Coordinates | 488037..488786 (+) | Length | 249 a.a. |
| NCBI ID | WP_046159788.1 | Uniprot ID | - |
| Organism | Streptococcus dysgalactiae subsp. equisimilis strain 159 | ||
| Function | activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 418623..490522 | 488037..488786 | within | 0 |
| IScluster/Tn | 486685..487790 | 488037..488786 | flank | 247 |
Gene organization within MGE regions
Location: 418623..490522
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H7680_RS02205 (SDSE159_03830) | - | 418645..419514 (+) | 870 | WP_015057356.1 | branched-chain amino acid ABC transporter permease | - |
| H7680_RS02210 (SDSE159_03840) | - | 419518..420471 (+) | 954 | WP_003062562.1 | branched-chain amino acid ABC transporter permease | - |
| H7680_RS02215 (SDSE159_03850) | - | 420472..421236 (+) | 765 | WP_003058688.1 | ABC transporter ATP-binding protein | - |
| H7680_RS02220 (SDSE159_03860) | - | 421242..421946 (+) | 705 | WP_171841621.1 | ABC transporter ATP-binding protein | - |
| H7680_RS02225 (SDSE159_03870) | - | 421991..422653 (+) | 663 | WP_003058678.1 | CBS domain-containing protein | - |
| H7680_RS02230 (SDSE159_03880) | tmk | 422740..423375 (+) | 636 | WP_003058667.1 | dTMP kinase | - |
| H7680_RS02235 (SDSE159_03890) | - | 423391..424263 (+) | 873 | WP_003058651.1 | DNA polymerase III subunit delta' | - |
| H7680_RS02240 (SDSE159_03900) | ricT | 424260..425060 (+) | 801 | WP_003058683.1 | regulatory iron-sulfur-containing complex subunit RicT | - |
| H7680_RS02245 (SDSE159_03910) | yabA | 425053..425376 (+) | 324 | WP_003058686.1 | DNA replication initiation control protein YabA | - |
| H7680_RS02250 (SDSE159_03920) | rsmI | 425381..426244 (+) | 864 | WP_003058668.1 | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | - |
| H7680_RS02255 (SDSE159_03930) | - | 426271..426663 (+) | 393 | WP_003058684.1 | DUF5684 domain-containing protein | - |
| H7680_RS02260 (SDSE159_03940) | - | 426710..427339 (-) | 630 | WP_003058655.1 | copper homeostasis protein CutC | - |
| H7680_RS02265 (SDSE159_03950) | serC | 427456..428547 (+) | 1092 | WP_003061119.1 | 3-phosphoserine/phosphohydroxythreonine transaminase | - |
| H7680_RS02270 (SDSE159_03960) | - | 428573..429124 (+) | 552 | WP_003061315.1 | GNAT family N-acetyltransferase | - |
| H7680_RS02275 (SDSE159_03970) | - | 429185..429682 (+) | 498 | WP_014612058.1 | methylated-DNA--[protein]-cysteine S-methyltransferase | - |
| H7680_RS02280 (SDSE159_03980) | - | 429679..430017 (+) | 339 | WP_150336169.1 | arsenate reductase family protein | - |
| H7680_RS02285 (SDSE159_03990) | - | 430086..430394 (-) | 309 | WP_003060273.1 | VOC family protein | - |
| H7680_RS02290 (SDSE159_04000) | - | 430396..430785 (-) | 390 | WP_014612059.1 | glyoxalase/bleomycin resistance/extradiol dioxygenase family protein | - |
| H7680_RS02295 (SDSE159_04010) | - | 430883..431818 (-) | 936 | WP_014612060.1 | LacI family DNA-binding transcriptional regulator | - |
| H7680_RS02300 (SDSE159_04020) | - | 431815..432627 (-) | 813 | WP_014612061.1 | HAD family hydrolase | - |
| H7680_RS02305 (SDSE159_04030) | - | 432756..433583 (-) | 828 | WP_012766623.1 | exodeoxyribonuclease III | - |
| H7680_RS02310 (SDSE159_04040) | - | 433872..434504 (+) | 633 | WP_003055618.1 | SdpI family protein | - |
| H7680_RS02315 (SDSE159_04050) | - | 434812..436332 (+) | 1521 | WP_003061592.1 | L-lactate permease | - |
| H7680_RS02320 (SDSE159_04060) | lctO | 436474..437655 (+) | 1182 | WP_003055631.1 | L-lactate oxidase | - |
| H7680_RS02325 | - | 437906..442656 (+) | 4751 | Protein_403 | S8 family serine peptidase | - |
| H7680_RS02330 (SDSE159_04100) | - | 442868..444535 (+) | 1668 | WP_014612063.1 | hypothetical protein | - |
| H7680_RS02335 (SDSE159_04110) | - | 444817..445524 (+) | 708 | WP_014612064.1 | YoaK family protein | - |
| H7680_RS02340 (SDSE159_04120) | metG | 445792..447789 (+) | 1998 | WP_014612065.1 | methionine--tRNA ligase | - |
| H7680_RS02345 (SDSE159_04130) | nrdF | 448322..449335 (+) | 1014 | WP_003055629.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| H7680_RS02350 (SDSE159_04140) | nrdI | 449339..449812 (+) | 474 | WP_014612066.1 | class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI | - |
| H7680_RS02355 (SDSE159_04150) | nrdE | 449796..451982 (+) | 2187 | WP_003055626.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| H7680_RS02360 (SDSE159_04160) | brnQ | 452280..453614 (+) | 1335 | WP_014612067.1 | branched-chain amino acid transport system II carrier protein | - |
| H7680_RS02365 (SDSE159_04180) | - | 454009..454362 (+) | 354 | WP_003054342.1 | hypothetical protein | - |
| H7680_RS02370 (SDSE159_04190) | - | 454711..454947 (+) | 237 | WP_003054401.1 | DUF2829 domain-containing protein | - |
| H7680_RS02375 (SDSE159_04200) | - | 454940..455638 (+) | 699 | WP_014612069.1 | 3-oxoacyl-ACP reductase | - |
| H7680_RS02380 (SDSE159_04210) | - | 455635..455877 (+) | 243 | WP_003049859.1 | DUF3977 family protein | - |
| H7680_RS02385 (SDSE159_04220) | - | 455895..456344 (+) | 450 | WP_014612070.1 | ASCH domain-containing protein | - |
| H7680_RS02390 (SDSE159_04230) | - | 456346..457305 (+) | 960 | WP_003054341.1 | Gfo/Idh/MocA family oxidoreductase | - |
| H7680_RS02395 (SDSE159_04240) | - | 457639..458976 (+) | 1338 | WP_003054334.1 | MFS transporter | - |
| H7680_RS02400 (SDSE159_04250) | glmU | 459148..460530 (+) | 1383 | WP_003054369.1 | bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU | - |
| H7680_RS02405 (SDSE159_04260) | - | 460561..461115 (+) | 555 | WP_003054386.1 | NUDIX hydrolase | - |
| H7680_RS02410 (SDSE159_04270) | macP | 461116..461367 (+) | 252 | WP_003054365.1 | cell wall synthase accessory phosphoprotein MacP | - |
| H7680_RS02415 (SDSE159_04280) | - | 461385..462080 (+) | 696 | WP_003054376.1 | 5'-methylthioadenosine/adenosylhomocysteine nucleosidase | - |
| H7680_RS02420 (SDSE159_04290) | - | 462153..462800 (-) | 648 | WP_003059888.1 | metal-dependent transcriptional regulator | - |
| H7680_RS02425 (SDSE159_04300) | - | 462946..463878 (+) | 933 | WP_014612072.1 | metal ABC transporter substrate-binding protein | - |
| H7680_RS02430 (SDSE159_04310) | - | 463943..464668 (+) | 726 | WP_003054363.1 | metal ABC transporter ATP-binding protein | - |
| H7680_RS02435 (SDSE159_04320) | - | 464669..465517 (+) | 849 | WP_003054335.1 | metal ABC transporter permease | - |
| H7680_RS02440 (SDSE159_04330) | - | 465648..466454 (-) | 807 | WP_003054349.1 | peptidylprolyl isomerase | - |
| H7680_RS02445 (SDSE159_04340) | - | 466672..469080 (+) | 2409 | WP_037587270.1 | DNA translocase FtsK | - |
| H7680_RS02450 (SDSE159_04350) | - | 469149..469502 (-) | 354 | WP_037587264.1 | DUF3397 domain-containing protein | - |
| H7680_RS02455 (SDSE159_04360) | rplK | 469745..470170 (+) | 426 | WP_003049875.1 | 50S ribosomal protein L11 | - |
| H7680_RS02460 (SDSE159_04370) | rplA | 470276..470965 (+) | 690 | WP_003049876.1 | 50S ribosomal protein L1 | - |
| H7680_RS02465 (SDSE159_04390) | - | 471423..471590 (-) | 168 | WP_003054374.1 | hypothetical protein | - |
| H7680_RS02470 (SDSE159_04400) | pyrH | 471872..472600 (+) | 729 | WP_003049878.1 | UMP kinase | - |
| H7680_RS02475 (SDSE159_04410) | frr | 472629..473186 (+) | 558 | WP_003054381.1 | ribosome recycling factor | - |
| H7680_RS02480 (SDSE159_04420) | - | 473295..474152 (+) | 858 | WP_003054345.1 | S1 RNA-binding domain-containing protein | - |
| H7680_RS02485 (SDSE159_04430) | msrA | 474225..474734 (+) | 510 | WP_003054395.1 | peptide-methionine (S)-S-oxide reductase MsrA | - |
| H7680_RS02490 (SDSE159_04440) | - | 474731..474946 (+) | 216 | WP_003054340.1 | YozE family protein | - |
| H7680_RS02495 (SDSE159_04450) | - | 475106..476341 (+) | 1236 | WP_003054361.1 | LysM domain-containing protein | - |
| H7680_RS02500 (SDSE159_04460) | - | 476652..478424 (+) | 1773 | WP_014612076.1 | oleate hydratase | - |
| H7680_RS02505 (SDSE159_04480) | - | 478585..479646 (+) | 1062 | WP_003054347.1 | PhoH family protein | - |
| H7680_RS02510 (SDSE159_04490) | - | 479693..480268 (+) | 576 | WP_003054351.1 | uracil-DNA glycosylase family protein | - |
| H7680_RS02515 (SDSE159_04500) | ybeY | 480427..480924 (+) | 498 | WP_003054373.1 | rRNA maturation RNase YbeY | - |
| H7680_RS02520 (SDSE159_04510) | - | 480905..481312 (+) | 408 | WP_003054389.1 | diacylglycerol kinase | - |
| H7680_RS02525 (SDSE159_04520) | era | 481433..482329 (+) | 897 | WP_003054336.1 | GTPase Era | - |
| H7680_RS10385 (SDSE159_04530) | - | 482516..482821 (+) | 306 | Protein_444 | NUDIX domain-containing protein | - |
| H7680_RS02530 | - | 482808..484501 (-) | 1694 | Protein_445 | ABC transporter transmembrane domain-containing protein | - |
| H7680_RS02540 (SDSE159_04560) | - | 484803..485030 (+) | 228 | WP_003054378.1 | bacteriocin-type signal sequence | - |
| H7680_RS02545 (SDSE159_04570) | - | 485079..485396 (+) | 318 | WP_002994587.1 | hypothetical protein | - |
| H7680_RS02550 (SDSE159_04580) | - | 485780..486043 (+) | 264 | WP_255306607.1 | Blp family class II bacteriocin | - |
| H7680_RS02555 (SDSE159_04590) | - | 486057..486242 (+) | 186 | WP_003054392.1 | hypothetical protein | - |
| H7680_RS02560 | - | 486496..486666 (+) | 171 | WP_014612080.1 | hypothetical protein | - |
| H7680_RS02565 | - | 486685..487790 (-) | 1106 | Protein_451 | IS3 family transposase | - |
| H7680_RS02570 (SDSE159_04640) | comE/blpR | 488037..488786 (+) | 750 | WP_046159788.1 | response regulator transcription factor | Regulator |
| H7680_RS02575 (SDSE159_04650) | - | 488787..490121 (+) | 1335 | WP_138127997.1 | GHKL domain-containing protein | - |
| H7680_RS02580 (SDSE159_04660) | - | 490182..490307 (-) | 126 | WP_011017462.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
Sequence
Protein
Download Length: 249 a.a. Molecular weight: 29211.53 Da Isoelectric Point: 5.6520
>NTDB_id=83052 H7680_RS02570 WP_046159788.1 488037..488786(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain 159]
MNIFILEDDFLQQSRIEKIIYKILTDNKWEINHLGVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PYAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK
MNIFILEDDFLQQSRIEKIIYKILTDNKWEINHLGVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PYAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK
Nucleotide
Download Length: 750 bp
>NTDB_id=83052 H7680_RS02570 WP_046159788.1 488037..488786(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain 159]
ATGAATATTTTTATTTTGGAAGATGATTTTTTACAACAAAGCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTGGGAGATTAACCACTTGGGAGTTTATGGTAAACCTAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAGATTGCTGTGGAGATTAGAAATAGAGAT
CCGTACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTGTCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG
ATGAATATTTTTATTTTGGAAGATGATTTTTTACAACAAAGCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTGGGAGATTAACCACTTGGGAGTTTATGGTAAACCTAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAGATTGCTGTGGAGATTAGAAATAGAGAT
CCGTACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTGTCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comE/blpR | Streptococcus mutans UA159 |
54.918 |
97.992 |
0.538 |
| comE/comE1 | Streptococcus equinus JB1 |
42.857 |
95.582 |
0.41 |
| comE/comE2 | Streptococcus gordonii strain NCTC7865 |
40.476 |
100 |
0.41 |
| comE/comE1 | Streptococcus gordonii str. Challis substr. CH1 |
40.476 |
100 |
0.41 |
| comE/comE2 | Streptococcus equinus JB1 |
40.984 |
97.992 |
0.402 |
| comE | Streptococcus mitis NCTC 12261 |
39.6 |
100 |
0.398 |
| comE | Streptococcus mitis SK321 |
39.6 |
100 |
0.398 |
| comE | Streptococcus pneumoniae Rx1 |
39.2 |
100 |
0.394 |
| comE | Streptococcus pneumoniae D39 |
39.2 |
100 |
0.394 |
| comE | Streptococcus pneumoniae R6 |
39.2 |
100 |
0.394 |
| comE | Streptococcus pneumoniae TIGR4 |
39.2 |
100 |
0.394 |
| comE | Streptococcus infantis strain Atu-4 |
39.113 |
99.598 |
0.39 |
| agrA | Staphylococcus aureus N315 |
36.585 |
98.795 |
0.361 |