Detailed information NTG0789869

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: PUW52_RS10600
• Genome accession: NZ_CP118078
• Coordinates: 2080249..2080998 (-)
• Length: 249 a.a.
• NCBI ID: WP_022526721.1
• Uniprot ID: A0AAN4P9A1
• Organism: Streptococcus anginosus strain VSI16
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2075249..2085998

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PUW52_RS10580 (PUW52_10580)	-	2075636..2077258 (+)	1623	WP_274984538.1	ATP-binding cassette domain-containing protein	-
PUW52_RS10585 (PUW52_10585)	-	2077325..2079901 (+)	2577	WP_274984539.1	YfhO family protein	-
PUW52_RS10600 (PUW52_10600)	comE	2080249..2080998 (-)	750	WP_022526721.1	competence system response regulator transcription factor ComE	Regulator
PUW52_RS10605 (PUW52_10605)	comD/comD2	2080998..2082323 (-)	1326	WP_274984617.1	GHKL domain-containing protein	Regulator
PUW52_RS10610 (PUW52_10610)	-	2082341..2082487 (-)	147	WP_003029519.1	bacteriocin	-
PUW52_RS10620 (PUW52_10620)	rlmH	2082769..2083248 (-)	480	WP_024052476.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
PUW52_RS10625 (PUW52_10625)	htrA	2083442..2084632 (+)	1191	WP_070812015.1	trypsin-like peptidase domain-containing protein	Regulator
PUW52_RS10630 (PUW52_10630)	spo0J	2084687..2085454 (+)	768	WP_274984540.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29216.88 Da
• Isoelectric Point: 8.6042

>NTDB_id=789869 PUW52_RS10600 WP_022526721.1 2080249..2080998(-) (comE) [Streptococcus anginosus strain VSI16]
MKVLVLEDEITHQVRMETTLAEIAKEMGITIKVKVTGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLSDVAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKETRRFFSPHKSYLVNIGNIKGYDKKMREIIFYEDHRCPITRMKIGKL
KAILEELKG

Nucleotide

• Length: 750 bp

>NTDB_id=789869 PUW52_RS10600 WP_022526721.1 2080249..2080998(-) (comE) [Streptococcus anginosus strain VSI16]
ATGAAAGTATTAGTATTAGAAGATGAAATTACACATCAAGTAAGAATGGAAACAACTTTGGCAGAGATTGCAAAAGAAAT
GGGAATTACGATAAAAGTTAAAGTAACTGGAAAAGTAAGGGAATTTAAAGAATATATTGAAAACGATGAAGTAAATCAAT
TATATTTTTTAGATATTGATATCAAAGGAGAGGAAACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCACAATCCG
TATGCCATTATTGTTTTTGTTACAACGAAATCAGAATTTGCCACTATGACCTTCAAATATAAGGTATCTGCACTGGATTT
TGTTGACAAAAATTTGAGTGATGTTGCTTTTAAAAAACATATAAAAGACAGCATTGAGTATACAAAAGCGACATTGATTG
AAAATAAAGATATGGTGGATTATTTTGAATATAGCTTTCGTGGCGGAGAGGTTAGAATGCCTTTTAATGACATTTTATAT
ATTGAAACGACAGGCTCTTCTCATAAATTAAGAATTGTCGGTAAAAACTTTTTTAAAGAATTCTATGGCACTATTGCAGA
TATTCAAGAAAAAGATAAAGAAACAAGACGTTTCTTTTCACCTCATAAATCCTACCTAGTCAATATTGGAAACATCAAAG
GTTATGACAAAAAAATGCGAGAAATAATTTTTTATGAAGATCATCGTTGTCCGATTACTCGAATGAAAATTGGAAAATTA
AAAGCTATTTTAGAGGAATTAAAAGGATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	70.612	98.394	0.695
comE/comE2	Streptococcus gordonii strain NCTC7865	70.492	97.992	0.691
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	70.492	97.992	0.691
comE	Streptococcus infantis strain Atu-4	69.796	98.394	0.687
comE	Streptococcus mitis SK321	69.796	98.394	0.687
comE	Streptococcus pneumoniae Rx1	69.388	98.394	0.683
comE	Streptococcus pneumoniae D39	69.388	98.394	0.683
comE	Streptococcus pneumoniae R6	69.388	98.394	0.683
comE	Streptococcus pneumoniae TIGR4	69.388	98.394	0.683
comE/blpR	Streptococcus mutans UA159	40.486	99.197	0.402
comE/comE2	Streptococcus equinus JB1	34.749	100	0.361