Detailed information NTG0782276

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: PO908_RS10135
• Genome accession: NZ_CP117042
• Coordinates: 1965224..1965973 (-)
• Length: 249 a.a.
• NCBI ID: WP_022526721.1
• Uniprot ID: A0AAN4P9A1
• Organism: Streptococcus anginosus strain CGMH_KH1
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1960224..1970973

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PO908_RS10115 (PO908_10080)	-	1960611..1962233 (+)	1623	WP_174721296.1	ABC-F family ATP-binding cassette domain-containing protein	-
PO908_RS10120 (PO908_10085)	-	1962300..1964876 (+)	2577	WP_394467989.1	YfhO family protein	-
PO908_RS10135 (PO908_10100)	comE	1965224..1965973 (-)	750	WP_022526721.1	competence system response regulator transcription factor ComE	Regulator
PO908_RS10140 (PO908_10105)	comD/comD2	1965973..1967295 (-)	1323	WP_394467990.1	sensor histidine kinase	Regulator
PO908_RS10145 (PO908_10110)	-	1967316..1967462 (-)	147	WP_003026814.1	bacteriocin	-
PO908_RS10155 (PO908_10120)	rlmH	1967744..1968223 (-)	480	WP_041784074.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
PO908_RS10160 (PO908_10125)	htrA	1968417..1969607 (+)	1191	WP_021002247.1	S1C family serine protease	Regulator
PO908_RS10165 (PO908_10130)	spo0J	1969662..1970429 (+)	768	WP_021002248.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29216.88 Da
• Isoelectric Point: 8.6042

>NTDB_id=782276 PO908_RS10135 WP_022526721.1 1965224..1965973(-) (comE) [Streptococcus anginosus strain CGMH_KH1]
MKVLVLEDEITHQVRMETTLAEIAKEMGITIKVKVTGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLSDVAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKETRRFFSPHKSYLVNIGNIKGYDKKMREIIFYEDHRCPITRMKIGKL
KAILEELKG

Nucleotide

• Length: 750 bp

>NTDB_id=782276 PO908_RS10135 WP_022526721.1 1965224..1965973(-) (comE) [Streptococcus anginosus strain CGMH_KH1]
ATGAAAGTATTAGTATTAGAAGATGAAATTACACATCAAGTAAGAATGGAAACAACTTTGGCAGAGATTGCAAAAGAAAT
GGGAATTACGATAAAAGTTAAAGTAACTGGAAAAGTAAGGGAATTTAAAGAATATATTGAAAACGATGAAGTAAATCAAT
TATATTTTTTAGATATTGATATCAAAGGAGAGGAAACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCACAATCCG
TATGCCATTATTGTTTTTGTTACAACGAAATCAGAATTTGCCACTATGACCTTCAAATATAAGGTATCTGCACTGGATTT
TGTTGATAAAAATTTGAGTGATGTTGCTTTTAAAAAACATATAAAAGACAGCATTGAGTATACAAAAGCGACATTGATTG
AAAATAAAGATATGGTGGATTATTTTGAATATAGCTTTCGTGGCGGAGAGGTTAGAATGCCTTTTAATGACATTTTATAT
ATTGAAACGACAGGCTCTTCTCATAAATTAAGAATTGTCGGTAAAAACTTTTTTAAAGAATTCTATGGCACTATTGCAGA
TATTCAAGAAAAAGATAAAGAAACAAGACGTTTCTTTTCACCTCATAAATCCTACCTAGTCAATATTGGAAACATCAAAG
GTTATGACAAAAAAATGCGAGAAATAATTTTTTATGAAGATCATCGTTGTCCGATTACTCGAATGAAAATTGGGAAATTA
AAAGCTATTTTAGAGGAATTAAAAGGATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	70.612	98.394	0.695
comE/comE2	Streptococcus gordonii strain NCTC7865	70.492	97.992	0.691
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	70.492	97.992	0.691
comE	Streptococcus infantis strain Atu-4	69.796	98.394	0.687
comE	Streptococcus mitis SK321	69.796	98.394	0.687
comE	Streptococcus pneumoniae Rx1	69.388	98.394	0.683
comE	Streptococcus pneumoniae D39	69.388	98.394	0.683
comE	Streptococcus pneumoniae R6	69.388	98.394	0.683
comE	Streptococcus pneumoniae TIGR4	69.388	98.394	0.683
comE/blpR	Streptococcus mutans UA159	40.486	99.197	0.402
comE/comE2	Streptococcus equinus JB1	34.749	100	0.361