Detailed information NTG0782278

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: PO908_RS10160
• Genome accession: NZ_CP117042
• Coordinates: 1968417..1969607 (+)
• Length: 396 a.a.
• NCBI ID: WP_021002247.1
• Uniprot ID: A0AAP6EPL7
• Organism: Streptococcus anginosus strain CGMH_KH1
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1963417..1974607

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PO908_RS10135 (PO908_10100)	comE	1965224..1965973 (-)	750	WP_022526721.1	competence system response regulator transcription factor ComE	Regulator
PO908_RS10140 (PO908_10105)	comD/comD2	1965973..1967295 (-)	1323	WP_394467990.1	sensor histidine kinase	Regulator
PO908_RS10145 (PO908_10110)	-	1967316..1967462 (-)	147	WP_003026814.1	bacteriocin	-
PO908_RS10155 (PO908_10120)	rlmH	1967744..1968223 (-)	480	WP_041784074.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
PO908_RS10160 (PO908_10125)	htrA	1968417..1969607 (+)	1191	WP_021002247.1	S1C family serine protease	Regulator
PO908_RS10165 (PO908_10130)	spo0J	1969662..1970429 (+)	768	WP_021002248.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 396 a.a.
• Molecular weight: 41680.65 Da
• Isoelectric Point: 9.5698

>NTDB_id=782278 PO908_RS10160 WP_021002247.1 1968417..1969607(+) (htrA) [Streptococcus anginosus strain CGMH_KH1]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTNSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLETNGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRNGKETTTTIKLTKSTKDLDSNN

Nucleotide

• Length: 1191 bp

>NTDB_id=782278 PO908_RS10160 WP_021002247.1 1968417..1969607(+) (htrA) [Streptococcus anginosus strain CGMH_KH1]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCCATAGGTTTTATCGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAAATAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTAAAAGATGCTGTGGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAATAGTGTGTTTGGAAATGACGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGGGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACTCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGAATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGTAAATTGACGGTTGGTGAGACAGCTATTGCGATTGGAAG
TCCGCTCGGATCAAATTACGCTAACACTGTGACGCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTTTAAAATCTG
AAGATGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATCAACCCAGGGAACTCTGGAGGACCACTTGTG
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAATTAGAAACAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGATAATATAAAAATCACTTTCTATC
GTAATGGAAAAGAGACCACTACCACTATAAAACTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

• PDZ domain (PDZ_2) (290-385)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	75.312	100	0.763
htrA	Streptococcus mitis NCTC 12261	72.796	100	0.73
htrA	Streptococcus pneumoniae Rx1	72.544	100	0.727
htrA	Streptococcus pneumoniae D39	72.544	100	0.727
htrA	Streptococcus pneumoniae R6	72.544	100	0.727
htrA	Streptococcus pneumoniae TIGR4	72.544	100	0.727
htrA	Streptococcus mutans UA159	55.471	99.242	0.551