Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   NPS16_RS08725 Genome accession   NZ_CP101986
Coordinates   1843916..1844668 (-) Length   250 a.a.
NCBI ID   WP_002270252.1    Uniprot ID   -
Organism   Streptococcus mutans strain COCC33-14     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1838916..1849668
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NPS16_RS10135 comB 1839128..1839280 (+) 153 WP_372552041.1 hypothetical protein Regulator
  NPS16_RS08695 (NPS16_08695) - 1839541..1839684 (-) 144 WP_002263740.1 hypothetical protein -
  NPS16_RS08700 (NPS16_08700) - 1839976..1840998 (-) 1023 WP_258968990.1 thioredoxin family protein -
  NPS16_RS08705 (NPS16_08705) - 1841483..1841671 (-) 189 WP_002270918.1 Blp family class II bacteriocin -
  NPS16_RS08710 (NPS16_08710) - 1841835..1842047 (-) 213 WP_002264173.1 Blp family class II bacteriocin -
  NPS16_RS08715 (NPS16_08715) comC/blpC 1842312..1842452 (+) 141 WP_002270250.1 ComC/BlpC family leader-containing pheromone/bacteriocin Regulator
  NPS16_RS08720 (NPS16_08720) comD/blpH 1842594..1843919 (-) 1326 WP_002267940.1 sensor histidine kinase Regulator
  NPS16_RS08725 (NPS16_08725) comE/blpR 1843916..1844668 (-) 753 WP_002270252.1 response regulator transcription factor Regulator
  NPS16_RS08730 (NPS16_08730) - 1845139..1845777 (-) 639 WP_002271525.1 VTT domain-containing protein -
  NPS16_RS08735 (NPS16_08735) - 1845825..1846451 (-) 627 WP_002273094.1 hypothetical protein -
  NPS16_RS08740 (NPS16_08740) der 1846526..1847836 (-) 1311 WP_002262117.1 ribosome biogenesis GTPase Der -
  NPS16_RS08745 (NPS16_08745) dnaI 1847849..1848748 (-) 900 WP_002273096.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29357.76 Da        Isoelectric Point: 8.2551

>NTDB_id=713672 NPS16_RS08725 WP_002270252.1 1843916..1844668(-) (comE/blpR) [Streptococcus mutans strain COCC33-14]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDAIPEKGSHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIELALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=713672 NPS16_RS08725 WP_002270252.1 1843916..1844668(-) (comE/blpR) [Streptococcus mutans strain COCC33-14]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAACAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGACGCTATCCCTGAAAAGGGCAGTC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCGGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATTAGCGCTGTATTATGCTATGGAAAACA
GTCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTCTACGGCAGTAT
GACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAACGCTTGGCCTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-123)

LytTr DNA-binding domain (LytTR)

(153-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

99.2

100

0.992
  comE/comE1 Streptococcus equinus JB1

46.888

96.4

0.452
  comE Streptococcus mitis NCTC 12261

41.7

98.8

0.412
  comE Streptococcus infantis strain Atu-4

41.7

98.8

0.412
  comE Streptococcus pneumoniae D39

41.296

98.8

0.408
  comE Streptococcus pneumoniae Rx1

41.296

98.8

0.408
  comE Streptococcus pneumoniae R6

41.296

98.8

0.408
  comE Streptococcus pneumoniae TIGR4

41.296

98.8

0.408
  comE Streptococcus mitis SK321

41.296

98.8

0.408
  comE/comE2 Streptococcus equinus JB1

40.664

96.4

0.392
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.551

98

0.368
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.551

98

0.368