Detailed information NTG0070012

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SA27298_RS09580
• Genome accession: NZ_AP018548
• Coordinates: 1950098..1950847 (-)
• Length: 249 a.a.
• NCBI ID: WP_018543656.1
• Uniprot ID: -
• Organism: Streptococcus anginosus strain CCUG 27928
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1945098..1955847

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SA27298_RS09560 (SA27298_1945)	-	1945485..1947107 (+)	1623	WP_003030724.1	ATP-binding cassette domain-containing protein	-
SA27298_RS09565 (SA27298_1946)	-	1947174..1949750 (+)	2577	WP_018543657.1	YfhO family protein	-
SA27298_RS09580 (SA27298_1949)	comE	1950098..1950847 (-)	750	WP_018543656.1	competence system response regulator transcription factor ComE	Regulator
SA27298_RS09585 (SA27298_1950)	comD/comD2	1950847..1952172 (-)	1326	WP_211209167.1	GHKL domain-containing protein	Regulator
SA27298_RS09590 (SA27298_1951)	-	1952190..1952336 (-)	147	WP_003029519.1	bacteriocin	-
SA27298_RS09600 (SA27298_1953)	rlmH	1952618..1953097 (-)	480	WP_003032032.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SA27298_RS09605 (SA27298_1954)	htrA	1953291..1954481 (+)	1191	WP_003032033.1	trypsin-like peptidase domain-containing protein	Regulator
SA27298_RS09610 (SA27298_1955)	spo0J	1954536..1955303 (+)	768	WP_003032028.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29221.90 Da
• Isoelectric Point: 8.9767

>NTDB_id=70012 SA27298_RS09580 WP_018543656.1 1950098..1950847(-) (comE) [Streptococcus anginosus strain CCUG 27928]
MKVLVLEDEISHQVRMETTLAEIAKEMGITIKVKVTGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLSDVAFKKRIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKETRRFFSPHKSYLVNIGNIKGYDKKMREIIFYEDHRCPITRMKIGKL
KAILEELKG

Nucleotide

• Length: 750 bp

>NTDB_id=70012 SA27298_RS09580 WP_018543656.1 1950098..1950847(-) (comE) [Streptococcus anginosus strain CCUG 27928]
ATGAAAGTATTAGTATTAGAAGATGAAATTTCACATCAAGTAAGAATGGAAACAACTTTGGCAGAAATTGCGAAAGAAAT
GGGAATTACAATAAAGGTTAAAGTAACTGGTAAAGTAAGAGAATTTAAAGAATATATTGAAAATGATGAGGTGAATCAAT
TATATTTTTTAGATATTGATATCAAAGGAGAGGAAACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCACAATCCG
TATGCCATTATTGTTTTTGTTACAACAAAATCAGAATTTGCTACGATGACCTTCAAATATAAGGTATCTGCACTGGATTT
TGTTGATAAAAATTTGAGTGATGTTGCTTTTAAAAAACGTATAAAAGACAGCATTGAGTATACAAAAGCAACATTGATTG
AAAATAAAGATATGGTGGATTATTTTGAATATAGCTTTCGTGGCGGAGAGGTTAGAATGCCTTTTAATGACATTTTATAT
ATTGAAACGACAGGCTCTTCTCATAAATTAAGAATTGTCGGTAAAAACTTTTTTAAAGAATTCTATGGCACTATTGCAGA
TATTCAAGAAAAAGATAAAGAAACAAGACGTTTCTTTTCACCTCATAAATCCTACCTAGTCAATATTGGAAACATCAAAG
GTTATGACAAAAAAATGCGAGAAATAATTTTTTATGAAGATCATCGTTGTCCGATTACTCGAATGAAAATTGGAAAATTA
AAAGCTATTTTAGAGGAATTAAAAGGATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (152-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.02	98.394	0.699
comE/comE2	Streptococcus gordonii strain NCTC7865	70.902	97.992	0.695
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	70.902	97.992	0.695
comE	Streptococcus infantis strain Atu-4	70.204	98.394	0.691
comE	Streptococcus mitis SK321	70.204	98.394	0.691
comE	Streptococcus pneumoniae Rx1	69.796	98.394	0.687
comE	Streptococcus pneumoniae D39	69.796	98.394	0.687
comE	Streptococcus pneumoniae R6	69.796	98.394	0.687
comE	Streptococcus pneumoniae TIGR4	69.796	98.394	0.687
comE/blpR	Streptococcus mutans UA159	40.891	99.197	0.406
comE/comE2	Streptococcus equinus JB1	34.749	100	0.361