Detailed information NTG0070014

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SA27298_RS09605
• Genome accession: NZ_AP018548
• Coordinates: 1953291..1954481 (+)
• Length: 396 a.a.
• NCBI ID: WP_003032033.1
• Uniprot ID: I0S836
• Organism: Streptococcus anginosus strain CCUG 27928
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1948291..1959481

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SA27298_RS09580 (SA27298_1949)	comE	1950098..1950847 (-)	750	WP_018543656.1	competence system response regulator transcription factor ComE	Regulator
SA27298_RS09585 (SA27298_1950)	comD/comD2	1950847..1952172 (-)	1326	WP_211209167.1	GHKL domain-containing protein	Regulator
SA27298_RS09590 (SA27298_1951)	-	1952190..1952336 (-)	147	WP_003029519.1	bacteriocin	-
SA27298_RS09600 (SA27298_1953)	rlmH	1952618..1953097 (-)	480	WP_003032032.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SA27298_RS09605 (SA27298_1954)	htrA	1953291..1954481 (+)	1191	WP_003032033.1	trypsin-like peptidase domain-containing protein	Regulator
SA27298_RS09610 (SA27298_1955)	spo0J	1954536..1955303 (+)	768	WP_003032028.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 396 a.a.
• Molecular weight: 41651.61 Da
• Isoelectric Point: 9.4264

>NTDB_id=70014 SA27298_RS09605 WP_003032033.1 1953291..1954481(+) (htrA) [Streptococcus anginosus strain CCUG 27928]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTNSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN

Nucleotide

• Length: 1191 bp

>NTDB_id=70014 SA27298_RS09605 WP_003032033.1 1953291..1954481(+) (htrA) [Streptococcus anginosus strain CCUG 27928]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATCGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAAATAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTGAAAGATGCTGTGGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGCGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGGGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACTCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGAATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGTAAATTGACGGTTGGTGAGACAGCTATTGCGATTGGAAG
TCCGCTCGGATCAAATTACGCTAACACTGTGACGCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTTTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATTAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

• PDZ domain (PDZ_2) (290-385)

3D structure

• AlphaFold DB: I0S836

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	75.561	100	0.765
htrA	Streptococcus mitis NCTC 12261	72.544	100	0.727
htrA	Streptococcus pneumoniae Rx1	72.292	100	0.725
htrA	Streptococcus pneumoniae D39	72.292	100	0.725
htrA	Streptococcus pneumoniae R6	72.292	100	0.725
htrA	Streptococcus pneumoniae TIGR4	72.292	100	0.725
htrA	Streptococcus mutans UA159	55.471	99.242	0.551