Detailed information NTG0692961

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: M9H69_RS10310
• Genome accession: NZ_CP097843
• Coordinates: 2057770..2058522 (-)
• Length: 250 a.a.
• NCBI ID: WP_250315577.1
• Uniprot ID: -
• Organism: Streptococcus oralis strain HP01
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2052770..2063522

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M9H69_RS10290 (M9H69_10290)	-	2054206..2056860 (-)	2655	WP_250315576.1	YhgE/Pip domain-containing protein	-
M9H69_RS10295 (M9H69_10295)	-	2056988..2057530 (+)	543	WP_000665086.1	TetR/AcrR family transcriptional regulator	-
M9H69_RS10310 (M9H69_10310)	comE	2057770..2058522 (-)	753	WP_250315577.1	competence system response regulator transcription factor ComE	Regulator
M9H69_RS10315 (M9H69_10315)	comD	2058519..2059838 (-)	1320	WP_250315578.1	competence system sensor histidine kinase ComD	Regulator
M9H69_RS10320 (M9H69_10320)	comC/comC2	2059859..2059984 (-)	126	WP_195215739.1	competence-stimulating peptide ComC	Regulator
M9H69_RS10330 (M9H69_10330)	rlmH	2060266..2060745 (-)	480	WP_250315579.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
M9H69_RS10335 (M9H69_10335)	htrA	2060930..2062120 (+)	1191	WP_084911880.1	S1C family serine protease	Regulator
M9H69_RS10340 (M9H69_10340)	spo0J	2062178..2062936 (+)	759	WP_250315580.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29857.21 Da
• Isoelectric Point: 6.9755

>NTDB_id=692961 M9H69_RS10310 WP_250315577.1 2057770..2058522(-) (comE) [Streptococcus oralis strain HP01]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKSFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=692961 M9H69_RS10310 WP_250315577.1 2057770..2058522(-) (comE) [Streptococcus oralis strain HP01]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAGCATCAAGTGAGACTAGAGAGAATATTGAATGAAATCTCTGAGGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATTGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAATTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACTAGTCGATCTGAATTTGCTACCTTAACGTACAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAAGATATCAATGATGAATTGTTCAAAAAACGCATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAAGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAGTTTTGCAAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAACTTAGAAGTTGTCTTTTATGAAGATCATCGTTGCCCCATTACCCGTTTGAAAGTTCGCAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.2	100	0.952
comE	Streptococcus mitis SK321	94.4	100	0.944
comE	Streptococcus pneumoniae Rx1	93.6	100	0.936
comE	Streptococcus pneumoniae D39	93.6	100	0.936
comE	Streptococcus pneumoniae R6	93.6	100	0.936
comE	Streptococcus pneumoniae TIGR4	93.6	100	0.936
comE	Streptococcus infantis strain Atu-4	93.2	100	0.932
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4