Detailed information NTG0692964

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: M9H69_RS10335
• Genome accession: NZ_CP097843
• Coordinates: 2060930..2062120 (+)
• Length: 396 a.a.
• NCBI ID: WP_084911880.1
• Uniprot ID: A0A1X0WM35
• Organism: Streptococcus oralis strain HP01
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2055930..2067120

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M9H69_RS10295 (M9H69_10295)	-	2056988..2057530 (+)	543	WP_000665086.1	TetR/AcrR family transcriptional regulator	-
M9H69_RS10310 (M9H69_10310)	comE	2057770..2058522 (-)	753	WP_250315577.1	competence system response regulator transcription factor ComE	Regulator
M9H69_RS10315 (M9H69_10315)	comD	2058519..2059838 (-)	1320	WP_250315578.1	competence system sensor histidine kinase ComD	Regulator
M9H69_RS10320 (M9H69_10320)	comC/comC2	2059859..2059984 (-)	126	WP_195215739.1	competence-stimulating peptide ComC	Regulator
M9H69_RS10330 (M9H69_10330)	rlmH	2060266..2060745 (-)	480	WP_250315579.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
M9H69_RS10335 (M9H69_10335)	htrA	2060930..2062120 (+)	1191	WP_084911880.1	S1C family serine protease	Regulator
M9H69_RS10340 (M9H69_10340)	spo0J	2062178..2062936 (+)	759	WP_250315580.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 396 a.a.
• Molecular weight: 41991.85 Da
• Isoelectric Point: 6.2506

>NTDB_id=692964 M9H69_RS10335 WP_084911880.1 2060930..2062120(+) (htrA) [Streptococcus oralis strain HP01]
MKHLQKFYKKGVTFLVIILIGFLSGALGSFVTLQLYQKQGNQATNNNSGTVTQTSYKNENSTTQAVNKIKDAVVSVITYS
ANKQSSVFGTEESNSDTDNQQIASEGSGVIYKKNENDAYIVTNTHVINGASKVDIRLADGTKVPGEIIGSDTFSDIAVVK
ISSEKVTTVAEFGDSSQLNVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGP
LVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVQNIIKQLESDGKVTRPALGIQMVNLSNVGANDLRKLNIPSGLTS
GVVVRSVQSNMPANGHLQKYDVITKVDEKEITSSTDLQHALYNHAIGDTIKITYYRNGKEETTSIKLDKNSGDLEH

Nucleotide

• Length: 1191 bp

>NTDB_id=692964 M9H69_RS10335 WP_084911880.1 2060930..2062120(+) (htrA) [Streptococcus oralis strain HP01]
ATGAAACACTTACAAAAATTTTACAAAAAAGGAGTTACTTTTCTTGTAATTATTCTAATAGGATTTTTGAGTGGTGCACT
AGGAAGTTTTGTAACATTGCAACTTTATCAAAAACAAGGAAATCAAGCTACAAATAATAATTCTGGCACTGTAACTCAAA
CATCATACAAGAATGAAAACTCAACTACTCAAGCAGTGAATAAAATTAAGGATGCTGTTGTATCAGTCATTACTTATTCT
GCTAATAAACAAAGTAGTGTATTTGGAACGGAAGAATCAAATTCTGATACGGATAATCAACAGATTGCAAGTGAAGGATC
AGGTGTCATCTATAAAAAGAACGAAAATGATGCTTATATTGTAACAAATACTCACGTTATTAACGGAGCTTCAAAAGTCG
ATATCCGTTTAGCTGATGGTACAAAAGTCCCTGGTGAAATTATTGGATCGGATACCTTCTCTGATATTGCTGTCGTAAAA
ATTTCTTCAGAAAAAGTTACAACAGTAGCAGAATTTGGTGATTCAAGCCAGCTTAATGTTGGAGAAACAGCGATTGCTAT
TGGTAGTCCTTTAGGTTCAGAATATGCTAATACAGTTACACAGGGAATCATCTCAAGTCTTAATCGAAATGTTTCTCTAA
AATCTGAAGATGGTCAAGCTATTTCAACAAAAGCCATTCAAACAGATACGGCCATTAACCCTGGTAACTCTGGTGGTCCG
CTTGTAAATATTCAAGGACAAGTAATTGGTATTACATCAAGTAAGATTGCAAGTAATGGTGGAACATCTGTAGAAGGTCT
TGGTTTTGCAATTCCTTCAAACGATGTACAAAATATTATTAAACAGCTTGAAAGTGATGGTAAAGTGACTCGTCCTGCTC
TTGGAATCCAAATGGTCAATCTGTCTAACGTTGGAGCTAATGATCTTAGAAAACTAAATATTCCAAGTGGCCTCACTTCA
GGTGTAGTTGTTCGATCTGTTCAAAGTAATATGCCTGCAAATGGACATCTTCAAAAATACGATGTCATTACTAAAGTTGA
CGAAAAAGAGATTACTTCATCAACAGACTTACAACATGCTCTTTACAACCATGCTATTGGAGACACTATAAAAATAACCT
ATTACCGTAATGGTAAGGAGGAAACAACCTCTATAAAACTAGATAAGAATTCTGGTGATTTGGAACATTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (106-251)

• PDZ domain (PDZ_2) (292-387)

3D structure

• AlphaFold DB: A0A1X0WM35

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	83.544	99.747	0.833
htrA	Streptococcus pneumoniae Rx1	82.785	99.747	0.826
htrA	Streptococcus pneumoniae D39	82.785	99.747	0.826
htrA	Streptococcus pneumoniae R6	82.785	99.747	0.826
htrA	Streptococcus pneumoniae TIGR4	82.785	99.747	0.826
htrA	Streptococcus gordonii str. Challis substr. CH1	64.824	100	0.652
htrA	Streptococcus mutans UA159	54.271	100	0.545