Detailed information NTG0692899

Bioinformatically predicted

Overview

• Name: comGC/cglC
• Type: Machinery gene
• Locus tag: M9H69_RS01185
• Genome accession: NZ_CP097843
• Coordinates: 213336..213659 (+)
• Length: 107 a.a.
• NCBI ID: WP_000735798.1
• Uniprot ID: A0A1X1HB54
• Organism: Streptococcus oralis strain HP01
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 208336..218659

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M9H69_RS01165 (M9H69_01165)	nagA	209694..210845 (+)	1152	WP_084876957.1	N-acetylglucosamine-6-phosphate deacetylase	-
M9H69_RS01170 (M9H69_01170)	-	210999..211364 (+)	366	WP_000286396.1	DUF1033 family protein	-
M9H69_RS01175 (M9H69_01175)	comGA/cglA/cilD	211429..212370 (+)	942	WP_213988900.1	competence type IV pilus ATPase ComGA	Machinery gene
M9H69_RS01180 (M9H69_01180)	comGB/cglB	212318..213334 (+)	1017	WP_213988901.1	competence type IV pilus assembly protein ComGB	Machinery gene
M9H69_RS01185 (M9H69_01185)	comGC/cglC	213336..213659 (+)	324	WP_000735798.1	competence type IV pilus major pilin ComGC	Machinery gene
M9H69_RS01190 (M9H69_01190)	comGD/cglD	213622..214056 (+)	435	WP_250315697.1	competence type IV pilus minor pilin ComGD	Machinery gene
M9H69_RS01195 (M9H69_01195)	comGE/cglE	214019..214321 (+)	303	WP_167266658.1	competence type IV pilus minor pilin ComGE	Machinery gene
M9H69_RS01200 (M9H69_01200)	comGF/cglF	214284..214745 (+)	462	WP_000250702.1	competence type IV pilus minor pilin ComGF	Machinery gene
M9H69_RS01205 (M9H69_01205)	comGG/cglG	214723..215136 (+)	414	WP_195217483.1	competence type IV pilus minor pilin ComGG	Machinery gene
M9H69_RS01210 (M9H69_01210)	-	215169..215759 (+)	591	WP_250315698.1	class I SAM-dependent methyltransferase	-
M9H69_RS01215 (M9H69_01215)	comYH	215818..216765 (+)	948	WP_250315699.1	class I SAM-dependent methyltransferase	Machinery gene
M9H69_RS01220 (M9H69_01220)	-	216823..218013 (+)	1191	WP_250315700.1	acetate kinase	-
M9H69_RS01225 (M9H69_01225)	rnpA	218162..218533 (+)	372	WP_000748120.1	ribonuclease P protein component	-

Sequence

Protein

• Length: 107 a.a.
• Molecular weight: 11891.03 Da
• Isoelectric Point: 10.1883

>NTDB_id=692899 M9H69_RS01185 WP_000735798.1 213336..213659(+) (comGC/cglC) [Streptococcus oralis strain HP01]
MKKLMTNLKKAKVKAFTLVEMLVVLLIISVLLLLFVPNLTKQKDAVDDKGKAAVVKVVESQAELYRLDKNDDASLSKLQA
DGRITAEQAKAYKDYHAKQKTSQTVAD

Nucleotide

• Length: 324 bp

>NTDB_id=692899 M9H69_RS01185 WP_000735798.1 213336..213659(+) (comGC/cglC) [Streptococcus oralis strain HP01]
ATGAAAAAACTTATGACAAATTTAAAAAAAGCCAAGGTTAAAGCTTTCACTTTGGTAGAAATGTTAGTCGTCTTGCTCAT
CATCAGCGTTCTTCTCTTGCTCTTTGTACCCAATTTGACCAAGCAAAAGGATGCCGTAGATGATAAAGGAAAAGCTGCTG
TTGTCAAGGTTGTGGAAAGCCAGGCAGAACTTTATCGTTTGGATAAAAATGATGATGCCAGTCTCAGCAAATTACAAGCG
GACGGTCGTATCACAGCAGAGCAAGCCAAAGCTTATAAAGACTACCATGCAAAACAAAAAACAAGTCAAACTGTTGCAGA
TTAA

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (11-34)

3D structure

• AlphaFold DB: A0A1X1HB54

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGC/cglC	Streptococcus mitis NCTC 12261	91.589	100	0.916
comGC/cglC	Streptococcus mitis SK321	88.889	92.523	0.822
comGC/cglC	Streptococcus pneumoniae R6	86.869	92.523	0.804
comGC/cglC	Streptococcus pneumoniae Rx1	86.869	92.523	0.804
comGC/cglC	Streptococcus pneumoniae D39	86.869	92.523	0.804
comGC/cglC	Streptococcus pneumoniae TIGR4	85.859	92.523	0.794
comYC	Streptococcus gordonii str. Challis substr. CH1	67.619	98.131	0.664
comYC	Streptococcus mutans UA140	70.103	90.654	0.636
comYC	Streptococcus mutans UA159	70.103	90.654	0.636
comGC	Lactococcus lactis subsp. cremoris KW2	57.426	94.393	0.542
comYC	Streptococcus suis isolate S10	65.909	82.243	0.542