Detailed information NTG0069026

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: STO1_RS00040
• Genome accession: NZ_AP018338
• Coordinates: 6137..6889 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866082.1
• Uniprot ID: -
• Organism: Streptococcus oralis subsp. tigurinus strain osk_001
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1137..11889

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STO1_RS00010 (STO1_000020)	spo0J	1732..2490 (-)	759	WP_045618162.1	ParB/RepB/Spo0J family partition protein	Regulator
STO1_RS00015 (STO1_000030)	htrA	2548..3738 (-)	1191	WP_007520971.1	S1C family serine protease	Regulator
STO1_RS00020 (STO1_000040)	rlmH	3924..4403 (+)	480	WP_007520969.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
STO1_RS00030 (STO1_000050)	comC	4686..4808 (+)	123	WP_007520968.1	competence-stimulating peptide ComC	Regulator
STO1_RS00035 (STO1_000060)	comD	4821..6140 (+)	1320	WP_007520967.1	competence system sensor histidine kinase ComD	Regulator
STO1_RS00040 (STO1_000070)	comE	6137..6889 (+)	753	WP_000866082.1	competence system response regulator transcription factor ComE	Regulator
STO1_RS00055 (STO1_000080)	-	7130..7672 (-)	543	WP_007520966.1	TetR/AcrR family transcriptional regulator	-
STO1_RS00060 (STO1_000090)	-	7800..10454 (+)	2655	WP_061588635.1	YhgE/Pip domain-containing protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29910.27 Da
• Isoelectric Point: 6.9162

>NTDB_id=69026 STO1_RS00040 WP_000866082.1 6137..6889(+) (comE) [Streptococcus oralis subsp. tigurinus strain osk_001]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIYGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=69026 STO1_RS00040 WP_000866082.1 6137..6889(+) (comE) [Streptococcus oralis subsp. tigurinus strain osk_001]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTAAATGAAATCTCGGAAGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATCGATATTTATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGTTTATTCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTCGCTACTTTAACTTATAAGTATCAGGTATCAGCTTTAGATTT
TGTAGATAAGGACATCAATGATGAATTGTTCAAAAAACGTATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAGGGAAATGATTTGAAAATTCCTTACCATGATATTCTGTAT
ATCGAAACAACAGGTGTTTCTCATAAATTGCGAATTATTGGTAAGAATTTTGCCAAAGAGTTTTATGGAACTATGACAGA
TATTCAGGAGAAGGACAAACATACTCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTAGGAAATGTGAGAG
AAATTGATCGAAAAAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGTCCTATTACCCGTTTGAAAGTTCGTAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.2	100	0.952
comE	Streptococcus mitis SK321	94.4	100	0.944
comE	Streptococcus pneumoniae Rx1	93.6	100	0.936
comE	Streptococcus pneumoniae D39	93.6	100	0.936
comE	Streptococcus pneumoniae R6	93.6	100	0.936
comE	Streptococcus pneumoniae TIGR4	93.6	100	0.936
comE	Streptococcus infantis strain Atu-4	93.2	100	0.932
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4