Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD   Type   Regulator
Locus tag   STO1_RS00035 Genome accession   NZ_AP018338
Coordinates   4821..6140 (+) Length   439 a.a.
NCBI ID   WP_007520967.1    Uniprot ID   S9RCY7
Organism   Streptococcus oralis subsp. tigurinus strain osk_001     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1..11140
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STO1_RS00005 (STO1_000010) dnaA 154..1515 (-) 1362 WP_007520973.1 chromosomal replication initiator protein DnaA -
  STO1_RS00010 (STO1_000020) spo0J 1732..2490 (-) 759 WP_045618162.1 ParB/RepB/Spo0J family partition protein Regulator
  STO1_RS00015 (STO1_000030) htrA 2548..3738 (-) 1191 WP_007520971.1 S1C family serine protease Regulator
  STO1_RS00020 (STO1_000040) rlmH 3924..4403 (+) 480 WP_007520969.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  STO1_RS00030 (STO1_000050) comC 4686..4808 (+) 123 WP_007520968.1 competence-stimulating peptide ComC Regulator
  STO1_RS00035 (STO1_000060) comD 4821..6140 (+) 1320 WP_007520967.1 competence system sensor histidine kinase ComD Regulator
  STO1_RS00040 (STO1_000070) comE 6137..6889 (+) 753 WP_000866082.1 competence system response regulator transcription factor ComE Regulator
  STO1_RS00055 (STO1_000080) - 7130..7672 (-) 543 WP_007520966.1 TetR/AcrR family transcriptional regulator -
  STO1_RS00060 (STO1_000090) - 7800..10454 (+) 2655 WP_061588635.1 YhgE/Pip domain-containing protein -

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 51573.31 Da        Isoelectric Point: 6.3493

>NTDB_id=69025 STO1_RS00035 WP_007520967.1 4821..6140(+) (comD) [Streptococcus oralis subsp. tigurinus strain osk_001]
MDFFAIISVILHIFITSKSYNLICNTTRKEQYFFIFYTVIVEFVIEFFFYSIYLSGLGIEKFLYPFILYAYFIWFKKFDK
YRGVFLSFLLSLLYHSTHTFIAVTLSSITGDELALHYESIFFLVVLLLTYFVILKTIRYFHLEIKYFDKDYLYPFLKKVI
VAFFGLHILLFVSDIVSTIHHLNSFGSILSTIVFICLLLVFFAMNSYKVQIEKEIALKQKKFEQKYLQTYTDEIVGLYNE
IRGFRHDYAGMLVSMQMAIDSGNLHEIDRIYNEVLVKANQKLRSDKYTYFDLNNIEDSALRSLIAQSIVYARNNDVEFTL
EVKDVITRLSMDLLDLVRIMSILLNNAVEGAADSYLKQMEVAVIKMDFETVIVIQNSCKITMTPSEDLFALGFSTKGRNR
GLGLNNVKEILDKYDNIILETEMEDNTFRQIIRFKREFE

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=69025 STO1_RS00035 WP_007520967.1 4821..6140(+) (comD) [Streptococcus oralis subsp. tigurinus strain osk_001]
ATGGATTTTTTCGCAATAATAAGCGTTATATTACATATTTTTATTACTAGTAAAAGTTATAATTTGATTTGTAATACAAC
TAGAAAAGAACAATACTTCTTTATTTTTTACACAGTAATAGTAGAATTTGTAATTGAATTTTTCTTCTATTCTATATATT
TAAGTGGACTAGGGATTGAAAAATTTTTATATCCATTTATTTTATACGCTTATTTTATATGGTTTAAAAAGTTTGATAAG
TATAGGGGAGTATTCCTAAGTTTCTTGCTTTCTCTCTTATATCATAGTACTCATACTTTTATAGCTGTAACCCTATCCTC
GATAACAGGTGATGAGCTTGCATTACACTATGAAAGTATATTCTTTCTAGTAGTATTGTTGTTGACTTATTTTGTTATTT
TAAAAACAATTCGTTATTTTCATTTGGAAATAAAATATTTTGATAAAGATTATCTGTACCCTTTTTTAAAAAAAGTAATA
GTTGCTTTCTTTGGTTTGCATATCTTATTGTTTGTTTCAGATATAGTAAGTACGATTCATCACTTAAATAGTTTTGGAAG
TATTTTATCAACCATTGTTTTTATCTGTCTGCTATTAGTTTTCTTTGCAATGAATTCTTATAAGGTTCAAATTGAAAAAG
AGATTGCCCTAAAGCAGAAGAAATTTGAACAAAAGTATTTACAAACTTATACAGATGAGATTGTGGGTTTGTATAATGAG
ATTCGAGGTTTTCGTCATGACTATGCAGGGATGCTTGTCAGCATGCAAATGGCGATTGACAGCGGAAATTTACACGAAAT
TGACAGGATTTACAACGAAGTCCTAGTAAAAGCAAATCAGAAATTGAGGTCAGACAAATATACTTACTTTGATTTAAATA
ACATAGAAGATTCGGCTTTACGAAGTTTAATTGCTCAATCGATTGTATATGCACGAAATAATGATGTAGAGTTTACATTG
GAAGTAAAAGATGTCATTACTAGATTGTCAATGGATTTACTTGATCTTGTTCGCATCATGAGTATTTTATTAAATAATGC
TGTTGAAGGTGCCGCAGATAGTTACTTGAAACAAATGGAAGTTGCAGTCATTAAAATGGATTTTGAAACAGTTATAGTTA
TCCAGAATTCATGTAAAATCACTATGACGCCTTCAGAAGATTTATTTGCCTTAGGTTTCTCTACCAAGGGAAGAAACAGA
GGTCTAGGACTTAATAATGTCAAGGAGATCTTAGATAAGTATGACAACATTATTTTAGAAACAGAAATGGAAGACAACAC
ATTTAGACAAATTATTAGATTTAAGAGAGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(332-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB S9RCY7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD Streptococcus mitis NCTC 12261

78.685

100

0.79
  comD/comD2 Streptococcus pneumoniae TIGR4

76.417

100

0.768
  comD/comD1 Streptococcus pneumoniae Rx1

76.19

100

0.765
  comD/comD1 Streptococcus pneumoniae D39

76.19

100

0.765
  comD/comD1 Streptococcus pneumoniae R6

76.19

100

0.765
  comD Streptococcus mitis SK321

75.057

100

0.754
  comD/comD2 Streptococcus gordonii strain NCTC7865

51.064

85.649

0.437
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

51.07

85.194

0.435

Multiple sequence alignment