Detailed information NTG0068381

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SNAG_RS09690
• Genome accession: NZ_AP017652
• Coordinates: 1919346..1920098 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866077.1
• Uniprot ID: E0PNN5
• Organism: Streptococcus sp. NPS 308
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1914346..1925098

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SNAG_RS09670 (SNAG_1893)	-	1915780..1918434 (-)	2655	WP_096408760.1	YhgE/Pip domain-containing protein	-
SNAG_RS09675 (SNAG_1894)	-	1918563..1919105 (+)	543	WP_061407778.1	TetR-like C-terminal domain-containing protein	-
SNAG_RS09690 (SNAG_1897)	comE	1919346..1920098 (-)	753	WP_000866077.1	competence system response regulator transcription factor ComE	Regulator
SNAG_RS09695 (SNAG_1898)	comD	1920095..1921414 (-)	1320	WP_096408763.1	competence system sensor histidine kinase ComD	Regulator
SNAG_RS09700 (SNAG_1899)	comC/comC2	1921435..1921560 (-)	126	WP_096408765.1	competence-stimulating peptide ComC	Regulator
SNAG_RS09710 (SNAG_1901)	rlmH	1921841..1922320 (-)	480	WP_096408768.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SNAG_RS09715 (SNAG_1902)	htrA	1922506..1923696 (+)	1191	WP_096408770.1	S1C family serine protease	Regulator
SNAG_RS09720 (SNAG_1903)	spo0J	1923754..1924512 (+)	759	WP_004239627.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29898.26 Da
• Isoelectric Point: 6.9755

>NTDB_id=68381 SNAG_RS09690 WP_000866077.1 1919346..1920098(-) (comE) [Streptococcus sp. NPS 308]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKIRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=68381 SNAG_RS09690 WP_000866077.1 1919346..1920098(-) (comE) [Streptococcus sp. NPS 308]
ATGAAAGTACTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTTGAGAGAATATTGAATGAAATCTCTGAGGAATC
AAATATTCCTATTTCGTACAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATTGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAATTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACGTACAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAAGATATCAATGATGAATTATTCAAAAAACGCATTGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAAGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCAAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGATAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGCTGTCCCATCACTCGTTTGAAAATTCGCAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: E0PNN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	96	100	0.96
comE	Streptococcus mitis SK321	95.2	100	0.952
comE	Streptococcus pneumoniae Rx1	94.4	100	0.944
comE	Streptococcus pneumoniae D39	94.4	100	0.944
comE	Streptococcus pneumoniae R6	94.4	100	0.944
comE	Streptococcus pneumoniae TIGR4	94.4	100	0.944
comE	Streptococcus infantis strain Atu-4	93.2	100	0.932
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4