Detailed information NTG0068384

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SNAG_RS09715
• Genome accession: NZ_AP017652
• Coordinates: 1922506..1923696 (+)
• Length: 396 a.a.
• NCBI ID: WP_096408770.1
• Uniprot ID: -
• Organism: Streptococcus sp. NPS 308
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1917506..1928696

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SNAG_RS09675 (SNAG_1894)	-	1918563..1919105 (+)	543	WP_061407778.1	TetR-like C-terminal domain-containing protein	-
SNAG_RS09690 (SNAG_1897)	comE	1919346..1920098 (-)	753	WP_000866077.1	competence system response regulator transcription factor ComE	Regulator
SNAG_RS09695 (SNAG_1898)	comD	1920095..1921414 (-)	1320	WP_096408763.1	competence system sensor histidine kinase ComD	Regulator
SNAG_RS09700 (SNAG_1899)	comC/comC2	1921435..1921560 (-)	126	WP_096408765.1	competence-stimulating peptide ComC	Regulator
SNAG_RS09710 (SNAG_1901)	rlmH	1921841..1922320 (-)	480	WP_096408768.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SNAG_RS09715 (SNAG_1902)	htrA	1922506..1923696 (+)	1191	WP_096408770.1	S1C family serine protease	Regulator
SNAG_RS09720 (SNAG_1903)	spo0J	1923754..1924512 (+)	759	WP_004239627.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 396 a.a.
• Molecular weight: 41869.72 Da
• Isoelectric Point: 6.3586

>NTDB_id=68384 SNAG_RS09715 WP_096408770.1 1922506..1923696(+) (htrA) [Streptococcus sp. NPS 308]
MKHLQKFYKKVVKVLAIILIGFLSGALGSFVTLQLYQKQGNQATNNNSNTVTQTSYKNETSTTQAVNKVKDAVVSVITYS
SNRQSSVFNGDETNSDSDNQQIASEGSGVIYKKDDKDAYLVTNTHVINGASKVDIRLADGTKVPGEIVGSDTFSDIAVVK
ISSEKVTTVAEFGDSSQLSVGETAIAIGSPLGSEYANTVTQGIISSLNRTVSLKSEDGQAISTKAIQTDTAINPGNSGGP
LVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESDGKVTRPALGIQMVNLANVGANDLRKLNIPSSLTS
GVVVRSVQSNMPANGHLQKYDVITKVDDKEIASSTDLQHALYTHAIGDTIKVTYYRNGKEETTSIKLDKNSGDLES

Nucleotide

• Length: 1191 bp

>NTDB_id=68384 SNAG_RS09715 WP_096408770.1 1922506..1923696(+) (htrA) [Streptococcus sp. NPS 308]
ATGAAACACTTACAAAAATTTTACAAAAAAGTAGTTAAAGTTCTTGCAATCATTCTAATAGGATTTTTAAGTGGTGCCTT
AGGAAGTTTCGTAACATTACAACTTTATCAAAAACAAGGAAATCAAGCTACAAATAATAATTCCAACACTGTTACCCAAA
CATCCTATAAGAATGAAACTTCAACTACCCAAGCAGTCAATAAAGTTAAAGATGCCGTTGTATCTGTTATTACTTATTCA
TCAAATAGACAAAGTAGTGTATTTAATGGTGATGAAACTAATTCTGATTCAGACAATCAACAAATCGCGAGTGAGGGATC
AGGTGTTATCTATAAAAAAGATGATAAAGATGCCTATCTTGTAACTAATACTCACGTTATCAATGGAGCTTCAAAAGTTG
ATATCCGCTTGGCAGATGGTACCAAGGTTCCTGGTGAGATTGTGGGATCTGATACTTTCTCTGATATTGCTGTCGTTAAA
ATTTCTTCAGAAAAAGTTACAACAGTAGCAGAATTTGGGGATTCAAGTCAACTTAGTGTTGGAGAAACAGCGATTGCTAT
CGGTAGTCCTCTAGGTTCAGAATATGCTAATACAGTTACACAGGGGATTATTTCAAGTCTTAATCGAACTGTATCTCTAA
AATCTGAAGATGGTCAAGCTATTTCTACAAAAGCTATTCAAACAGACACTGCTATTAACCCAGGTAATTCTGGTGGTCCA
CTTGTAAACATTCAAGGTCAAGTAATTGGTATTACATCAAGTAAAATTGCAAGTAATGGTGGAACATCTGTAGAAGGTCT
TGGTTTTGCAATTCCTTCAAACGATGCACAAAATATCATTAAACAGCTTGAAAGTGATGGTAAAGTGACTCGTCCAGCTC
TTGGAATTCAAATGGTCAATTTGGCTAATGTTGGAGCGAATGATCTGAGAAAACTCAACATCCCAAGTAGTCTTACTTCA
GGTGTAGTTGTTCGATCTGTTCAAAGTAATATGCCAGCAAATGGACATCTTCAAAAATACGACGTCATTACTAAAGTTGA
CGACAAAGAGATTGCCTCATCAACAGACCTACAACACGCTCTTTATACTCATGCTATCGGAGATACTATCAAAGTAACCT
ACTACCGTAATGGTAAAGAGGAAACAACCTCTATTAAGCTTGATAAGAATTCAGGTGATCTAGAGTCTTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (292-387)

• Trypsin-like peptidase domain (Trypsin_2) (106-251)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	83.081	100	0.831
htrA	Streptococcus pneumoniae Rx1	82.071	100	0.821
htrA	Streptococcus pneumoniae D39	82.071	100	0.821
htrA	Streptococcus pneumoniae R6	82.071	100	0.821
htrA	Streptococcus pneumoniae TIGR4	82.071	100	0.821
htrA	Streptococcus gordonii str. Challis substr. CH1	65.75	100	0.664
htrA	Streptococcus mutans UA159	54.637	100	0.551