Detailed information NTG0668135

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: MP387_RS09095
• Genome accession: NZ_CP094226
• Coordinates: 1871351..1872103 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866079.1
• Uniprot ID: A0A081R422
• Organism: Streptococcus oralis strain 1648
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1866351..1877103

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MP387_RS09075 (MP387_09075)	-	1867788..1870442 (-)	2655	WP_242746611.1	YhgE/Pip domain-containing protein	-
MP387_RS09080 (MP387_09080)	-	1870571..1871113 (+)	543	WP_000665080.1	TetR-like C-terminal domain-containing protein	-
MP387_RS09095 (MP387_09095)	comE	1871351..1872103 (-)	753	WP_000866079.1	competence system response regulator transcription factor ComE	Regulator
MP387_RS09100 (MP387_09100)	comD	1872100..1873419 (-)	1320	WP_242746613.1	competence system sensor histidine kinase ComD	Regulator
MP387_RS09105 (MP387_09105)	comC/comC1	1873440..1873565 (-)	126	WP_008282505.1	competence-stimulating peptide ComC	Regulator
MP387_RS09115 (MP387_09115)	rlmH	1873847..1874326 (-)	480	WP_242746617.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
MP387_RS09120 (MP387_09120)	htrA	1874512..1875705 (+)	1194	WP_242746621.1	S1C family serine protease	Regulator
MP387_RS09125 (MP387_09125)	spo0J	1875763..1876521 (+)	759	WP_242746624.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29884.23 Da
• Isoelectric Point: 6.9755

>NTDB_id=668135 MP387_RS09095 WP_000866079.1 1871351..1872103(-) (comE) [Streptococcus oralis strain 1648]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=668135 MP387_RS09095 WP_000866079.1 1871351..1872103(-) (comE) [Streptococcus oralis strain 1648]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTAAATGAAATCTCGGAAGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATTGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAGTTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACTAGTCGCTCTGAATTTGCTACCTTAACGTACAAATACCAAGTATCAGCCCTAGATTT
TGTTGATAAAGATATCAATGATGAATTGTTCAAAAAACGCATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAAGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCTAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGCCCGATTACCCGTTTGAAAGTTCGCAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081R422

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.6	100	0.956
comE	Streptococcus mitis SK321	94.8	100	0.948
comE	Streptococcus pneumoniae Rx1	94	100	0.94
comE	Streptococcus pneumoniae D39	94	100	0.94
comE	Streptococcus pneumoniae R6	94	100	0.94
comE	Streptococcus pneumoniae TIGR4	94	100	0.94
comE	Streptococcus infantis strain Atu-4	93.6	100	0.936
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4