Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC1   Type   Regulator
Locus tag   MP387_RS09105 Genome accession   NZ_CP094226
Coordinates   1873440..1873565 (-) Length   41 a.a.
NCBI ID   WP_008282505.1    Uniprot ID   A0A139Q4L7
Organism   Streptococcus oralis strain 1648     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 1868440..1878565
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MP387_RS09080 (MP387_09080) - 1870571..1871113 (+) 543 WP_000665080.1 TetR-like C-terminal domain-containing protein -
  MP387_RS09095 (MP387_09095) comE 1871351..1872103 (-) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  MP387_RS09100 (MP387_09100) comD 1872100..1873419 (-) 1320 WP_242746613.1 competence system sensor histidine kinase ComD Regulator
  MP387_RS09105 (MP387_09105) comC/comC1 1873440..1873565 (-) 126 WP_008282505.1 competence-stimulating peptide ComC Regulator
  MP387_RS09115 (MP387_09115) rlmH 1873847..1874326 (-) 480 WP_242746617.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  MP387_RS09120 (MP387_09120) htrA 1874512..1875705 (+) 1194 WP_242746621.1 S1C family serine protease Regulator
  MP387_RS09125 (MP387_09125) spo0J 1875763..1876521 (+) 759 WP_242746624.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4957.73 Da        Isoelectric Point: 10.2767

>NTDB_id=668137 MP387_RS09105 WP_008282505.1 1873440..1873565(-) (comC/comC1) [Streptococcus oralis strain 1648]
MKNTVKLEQFKEVTEAELQEIRGGDKRLPYFFKHLFSNRTK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=668137 MP387_RS09105 WP_008282505.1 1873440..1873565(-) (comC/comC1) [Streptococcus oralis strain 1648]
ATGAAAAATACAGTAAAGTTGGAACAATTTAAAGAAGTAACAGAGGCAGAATTGCAGGAGATTCGAGGTGGAGATAAAAG
ACTACCTTACTTTTTTAAACATCTTTTTTCAAATAGGACAAAGTAG

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-31)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A139Q4L7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC1 Streptococcus pneumoniae R6

53.659

100

0.537
  comC/comC1 Streptococcus pneumoniae G54

53.659

100

0.537
  comC/comC1 Streptococcus pneumoniae D39

53.659

100

0.537
  comC/comC1 Streptococcus pneumoniae Rx1

53.659

100

0.537
  comC Streptococcus mitis SK321

68.966

70.732

0.488
  comC/comC2 Streptococcus pneumoniae A66

58.621

70.732

0.415
  comC/comC2 Streptococcus pneumoniae TIGR4

58.621

70.732

0.415
  comC Streptococcus mitis NCTC 12261

55.556

65.854

0.366
  comC/blpC Streptococcus mutans UA159

44.118

82.927

0.366

Multiple sequence alignment