Detailed information NTG0061630

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SCI_RS09940
• Genome accession: NC_022238
• Coordinates: 1985945..1986694 (-)
• Length: 249 a.a.
• NCBI ID: WP_003071650.1
• Uniprot ID: A0A380L579
• Organism: Streptococcus constellatus subsp. pharyngis C1050
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1980945..1991694

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCI_RS09920 (SCI_1933)	-	1981350..1982972 (+)	1623	WP_006268876.1	ABC-F family ATP-binding cassette domain-containing protein	-
SCI_RS09925 (SCI_1934)	-	1983046..1985625 (+)	2580	WP_020998130.1	YfhO family protein	-
SCI_RS09940 (SCI_1937)	comE	1985945..1986694 (-)	750	WP_003071650.1	competence system response regulator transcription factor ComE	Regulator
SCI_RS09945 (SCI_1938)	comD/comD1	1986694..1988007 (-)	1314	WP_020998131.1	GHKL domain-containing protein	Regulator
SCI_RS10430 (SCI_1939)	-	1988027..1988173 (-)	147	WP_006268843.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SCI_RS09960 (SCI_1941)	rlmH	1988456..1988935 (-)	480	WP_006268880.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SCI_RS09965 (SCI_1942)	htrA	1989140..1990330 (+)	1191	WP_006270334.1	S1C family serine protease	Regulator
SCI_RS09970 (SCI_1943)	spo0J	1990385..1991152 (+)	768	WP_003071657.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29171.69 Da
• Isoelectric Point: 8.0453

>NTDB_id=61630 SCI_RS09940 WP_003071650.1 1985945..1986694(-) (comE) [Streptococcus constellatus subsp. pharyngis C1050]
MKVLILEDEITHQVRMETTLAEIAKEMGIPIKVKITGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLNDAAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDEKTQRFFSPHKSYLVNIGNIKGYDKKTREIIFYEDHRCPITRMKIGKL
KSILEESKG

Nucleotide

• Length: 750 bp

>NTDB_id=61630 SCI_RS09940 WP_003071650.1 1985945..1986694(-) (comE) [Streptococcus constellatus subsp. pharyngis C1050]
ATGAAAGTACTAATATTAGAAGATGAAATTACACATCAAGTTAGAATGGAAACAACATTGGCAGAAATAGCTAAGGAAAT
GGGGATTCCGATAAAAGTTAAAATAACTGGAAAAGTAAGAGAATTTAAAGAATATATTGAAAACGATGAAGTAAATCAAT
TATATTTTTTAGATATTGATATTAAAGGTGAAGAAACAAAAGGGTTAGAAATAGCCAAATTTATACGGCATCACAATCCT
TATGCCATTATTGTTTTTGTTACAACAAAATCAGAATTTGCTACTATGACGTTTAAATATAAAGTATCTGCATTGGATTT
TGTTGATAAAAATTTGAATGATGCTGCTTTTAAAAAACATATAAAAGACAGTATTGAGTATACAAAAGCAACGTTGATTG
AAAATAAAGATATGGTTGATTATTTTGAATATAGTTTCCGTGGTGGCGAGGTTAGAATGCCTTTTAATGATATTTTATAT
ATTGAAACGACAGGTTCTTCTCATAAATTAAGAATTGTTGGTAAAAACTTTTTTAAAGAATTTTATGGTACGATTGCAGA
TATTCAGGAAAAAGACGAGAAAACACAGCGCTTCTTTTCACCTCATAAATCTTATCTAGTTAATATTGGGAATATTAAAG
GTTATGACAAAAAAACGAGAGAAATTATTTTTTATGAAGATCACCGTTGTCCGATTACTCGAATGAAAATTGGAAAGTTG
AAATCTATTTTAGAGGAGTCAAAAGGATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (152-244)

3D structure

• AlphaFold DB: A0A380L579

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.837	98.394	0.707
comE	Streptococcus infantis strain Atu-4	71.02	98.394	0.699
comE	Streptococcus mitis SK321	71.02	98.394	0.699
comE	Streptococcus pneumoniae Rx1	70.612	98.394	0.695
comE	Streptococcus pneumoniae D39	70.612	98.394	0.695
comE	Streptococcus pneumoniae R6	70.612	98.394	0.695
comE	Streptococcus pneumoniae TIGR4	70.612	98.394	0.695
comE/comE2	Streptococcus gordonii strain NCTC7865	69.672	97.992	0.683
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	69.672	97.992	0.683
comE/blpR	Streptococcus mutans UA159	39.759	100	0.398
comE/comE2	Streptococcus equinus JB1	35.019	100	0.361