Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SCRE_RS04775 Genome accession   NC_022236
Coordinates   954703..955377 (-) Length   224 a.a.
NCBI ID   WP_003068917.1    Uniprot ID   F9P6F2
Organism   Streptococcus constellatus subsp. pharyngis C232     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 949703..960377
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCRE_RS04765 (SCRE_0938) - 951487..952935 (+) 1449 WP_006267911.1 alpha-amylase -
  SCRE_RS04770 (SCRE_0939) ciaH 953367..954713 (-) 1347 WP_006267810.1 sensor histidine kinase Regulator
  SCRE_RS04775 (SCRE_0940) ciaR 954703..955377 (-) 675 WP_003068917.1 response regulator transcription factor Regulator
  SCRE_RS04780 (SCRE_0941) - 955641..956084 (-) 444 WP_020997812.1 hypothetical protein -
  SCRE_RS04785 (SCRE_0942) - 956412..957170 (-) 759 WP_020997813.1 alpha/beta hydrolase -
  SCRE_RS04790 (SCRE_0943) - 957633..957881 (+) 249 WP_003024345.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  SCRE_RS04795 (SCRE_0944) - 957878..958174 (+) 297 WP_006267547.1 type II toxin-antitoxin system RelE family toxin -
  SCRE_RS04800 (SCRE_0945) - 958282..959130 (-) 849 WP_020997815.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25300.97 Da        Isoelectric Point: 4.2703

>NTDB_id=61466 SCRE_RS04775 WP_003068917.1 954703..955377(-) (ciaR) [Streptococcus constellatus subsp. pharyngis C232]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKGLREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTINLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=61466 SCRE_RS04775 WP_003068917.1 954703..955377(-) (ciaR) [Streptococcus constellatus subsp. pharyngis C232]
ATGATTAAGATTCTATTAGTAGAAGATGACCTTGGTTTATCTAACTCAGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAGGAAGGATTGTACGAAGCCGAAAGTGGTGTGTACGATCTTATCTTACTTGATTTGATGT
TACCGGAAAAAGACGGTTTTCAAGTATTGAAGGGATTACGTGAAAAAGGTGTTACAACACCGGTATTGATTATGACAGCT
AAAGAGAGTTTGAATGATAAAGGACATGGCTTTGAGCTGGGAGCCGACGATTATTTGACCAAACCATTTTATTTGGAAGA
GTTAAAAATGCGGATTCAAGCTCTTTTGAAACGATCGGGCAAGTTTAATGAAAATACTCTTTCTTATGGCGATGTAACCA
TTAATTTGTCAACGAACACGACACTTGTAGATGGAAATGAAGTAGAGTTACTCGGAAAAGAATTTGATTTATTAGTATAT
TTCTTGCAGAATCAAAATGTTATTCTACCGAAGACGCAGATTTTCGATCGCTTATGGGGGTTTGATAGTGATACAACCAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATTCGGAAAAAATTGAAAGGGACGACCTTTGCGAATAATCTTCAAACACTTC
GCAGCGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F9P6F2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.071

100

0.911
  ciaR Streptococcus pneumoniae D39

91.071

100

0.911
  ciaR Streptococcus pneumoniae R6

91.071

100

0.911
  ciaR Streptococcus pneumoniae TIGR4

91.071

100

0.911
  ciaR Streptococcus mutans UA159

89.238

99.554

0.888
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment