Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   NPS18_RS08875 Genome accession   NZ_CP101984
Coordinates   1796823..1797575 (-) Length   250 a.a.
NCBI ID   WP_002262114.1    Uniprot ID   Q8DS93
Organism   Streptococcus mutans strain UA-159     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1791823..1802575
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NPS18_RS08845 (NPS18_08845) - 1791839..1792243 (-) 405 WP_002263912.1 hypothetical protein -
  NPS18_RS08850 (NPS18_08850) - 1792390..1792809 (-) 420 WP_002263913.1 hypothetical protein -
  NPS18_RS08855 (NPS18_08855) - 1794190..1794591 (-) 402 WP_002310604.1 hypothetical protein -
  NPS18_RS08860 (NPS18_08860) cipB 1794722..1794952 (-) 231 WP_002265368.1 Blp family class II bacteriocin Regulator
  NPS18_RS08865 (NPS18_08865) comC/blpC 1795219..1795359 (+) 141 WP_002267610.1 ComC/BlpC family leader-containing pheromone/bacteriocin Regulator
  NPS18_RS08870 (NPS18_08870) comD/blpH 1795501..1796826 (-) 1326 WP_002262113.1 sensor histidine kinase Regulator
  NPS18_RS08875 (NPS18_08875) comE/blpR 1796823..1797575 (-) 753 WP_002262114.1 response regulator transcription factor Regulator
  NPS18_RS08880 (NPS18_08880) - 1798047..1798685 (-) 639 WP_002262115.1 VTT domain-containing protein -
  NPS18_RS08885 (NPS18_08885) - 1798732..1799358 (-) 627 WP_002262116.1 hypothetical protein -
  NPS18_RS08890 (NPS18_08890) der 1799433..1800743 (-) 1311 WP_002262117.1 ribosome biogenesis GTPase Der -
  NPS18_RS08895 (NPS18_08895) dnaI 1800756..1801655 (-) 900 WP_002262118.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29358.71 Da        Isoelectric Point: 8.2551

>NTDB_id=613659 NPS18_RS08875 WP_002262114.1 1796823..1797575(-) (comE/blpR) [Streptococcus mutans strain UA-159]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDAIPEKGNHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIESALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=613659 NPS18_RS08875 WP_002262114.1 1796823..1797575(-) (comE/blpR) [Streptococcus mutans strain UA-159]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAACAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGACGCTATCCCTGAAAAGGGCAATC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCAGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATCAGCGCTGTATTATGCTATGGAAAACA
GCCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTCTACGGCAGTAT
GACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAACGCTTGGCCTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-123)

LytTr DNA-binding domain (LytTR)

(153-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DS93

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

100

100

1
  comE/comE1 Streptococcus equinus JB1

46.888

96.4

0.452
  comE Streptococcus mitis NCTC 12261

41.7

98.8

0.412
  comE Streptococcus infantis strain Atu-4

41.7

98.8

0.412
  comE Streptococcus pneumoniae D39

41.296

98.8

0.408
  comE Streptococcus pneumoniae Rx1

41.296

98.8

0.408
  comE Streptococcus pneumoniae R6

41.296

98.8

0.408
  comE Streptococcus pneumoniae TIGR4

41.296

98.8

0.408
  comE Streptococcus mitis SK321

41.296

98.8

0.408
  comE/comE2 Streptococcus equinus JB1

40.664

96.4

0.392
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.551

98

0.368
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.551

98

0.368