Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/blpH   Type   Regulator
Locus tag   NPS18_RS08870 Genome accession   NZ_CP101984
Coordinates   1795501..1796826 (-) Length   441 a.a.
NCBI ID   WP_002262113.1    Uniprot ID   Q8DS94
Organism   Streptococcus mutans strain UA-159     
Function   phosphorylation of ComE; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1790501..1801826
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NPS18_RS08835 (NPS18_08835) - 1790900..1791064 (-) 165 WP_002265308.1 hypothetical protein -
  NPS18_RS08840 (NPS18_08840) - 1791504..1791716 (+) 213 Protein_1696 IS3 family transposase -
  NPS18_RS08845 (NPS18_08845) - 1791839..1792243 (-) 405 WP_002263912.1 hypothetical protein -
  NPS18_RS08850 (NPS18_08850) - 1792390..1792809 (-) 420 WP_002263913.1 hypothetical protein -
  NPS18_RS08855 (NPS18_08855) - 1794190..1794591 (-) 402 WP_002310604.1 hypothetical protein -
  NPS18_RS08860 (NPS18_08860) cipB 1794722..1794952 (-) 231 WP_002265368.1 Blp family class II bacteriocin Regulator
  NPS18_RS08865 (NPS18_08865) comC/blpC 1795219..1795359 (+) 141 WP_002267610.1 ComC/BlpC family leader-containing pheromone/bacteriocin Regulator
  NPS18_RS08870 (NPS18_08870) comD/blpH 1795501..1796826 (-) 1326 WP_002262113.1 sensor histidine kinase Regulator
  NPS18_RS08875 (NPS18_08875) comE/blpR 1796823..1797575 (-) 753 WP_002262114.1 response regulator transcription factor Regulator
  NPS18_RS08880 (NPS18_08880) - 1798047..1798685 (-) 639 WP_002262115.1 VTT domain-containing protein -
  NPS18_RS08885 (NPS18_08885) - 1798732..1799358 (-) 627 WP_002262116.1 hypothetical protein -
  NPS18_RS08890 (NPS18_08890) der 1799433..1800743 (-) 1311 WP_002262117.1 ribosome biogenesis GTPase Der -
  NPS18_RS08895 (NPS18_08895) dnaI 1800756..1801655 (-) 900 WP_002262118.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 50540.70 Da        Isoelectric Point: 9.8211

>NTDB_id=613658 NPS18_RS08870 WP_002262113.1 1795501..1796826(-) (comD/blpH) [Streptococcus mutans strain UA-159]
MNEALMILSNGLLTYLTVLFLLFLFSKVSNVTLSKKELTLFSISNFLIMIAVTMVNVNLFYPAEPLYFIALSIYLNRQNS
LSLNIFYGLLPVASSDLFRRAIIFFILDGTQGIVMGSSIITTYMIEFAGIALSYLFLSVFNVDIGRLKDSLTKMKVKKRL
IPMNITMLLYYLLIQVLYVIESYNVIPTLKFRKFVVIVYLILFLILISFLSQYTKQKVQNEIMAQKEAQIRNITQYSQQI
ESLYKDIRSFRHDYLNILTSLRLGIENKDLASIEKIYHQILEKTGHQLQDTRYNIGHLANIQNDAVKGILSAKILEAQNK
KIAVNVEVSSKIQLPEMELLDFITILSILCDNAIEAAFESLNPEIQLAFFKKNGSIVFIIQNSTKEKQIDVSKIFKENYS
TKGSNRGIGLAKVNHILEHYPKTSLQTSNHHHLFKQLLIIK

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=613658 NPS18_RS08870 WP_002262113.1 1795501..1796826(-) (comD/blpH) [Streptococcus mutans strain UA-159]
ATGAATGAAGCCTTAATGATACTTTCAAATGGTTTATTAACTTATCTAACCGTTCTATTTCTCTTGTTTCTATTTTCTAA
GGTAAGTAATGTCACTTTATCGAAAAAGGAATTAACTCTTTTTTCGATAAGCAATTTTCTGATAATGATTGCTGTTACGA
TGGTGAACGTAAACCTGTTTTATCCTGCAGAGCCTCTTTATTTTATAGCTTTATCAATTTATCTTAATAGACAGAATAGT
CTTTCTCTAAATATATTTTATGGTCTGCTGCCTGTTGCCAGTTCTGACTTGTTTAGGCGGGCAATCATATTCTTTATCTT
GGATGGAACTCAAGGAATTGTAATGGGCAGTAGCATTATAACCACCTATATGATCGAGTTTGCAGGAATAGCGCTAAGTT
ACCTCTTTCTCAGTGTGTTCAATGTTGATATTGGTCGACTTAAAGATAGTTTGACCAAGATGAAGGTCAAAAAACGCTTG
ATTCCAATGAATATTACTATGCTTCTATACTACCTTTTAATACAGGTATTGTATGTTATAGAGAGTTATAATGTGATACC
GACTTTAAAATTTCGTAAATTTGTCGTTATTGTCTATCTTATTTTATTTTTGATTCTGATCTCATTTTTAAGCCAATATA
CCAAACAAAAGGTTCAAAATGAGATAATGGCACAAAAGGAAGCTCAGATTCGAAATATCACCCAGTATAGTCAGCAAATA
GAATCTCTTTACAAGGATATTCGAAGTTTCCGCCATGATTATCTGAATATTTTAACTAGCCTCAGATTAGGCATTGAAAA
TAAAGATTTAGCTAGTATTGAAAAGATTTACCATCAAATCTTAGAAAAAACAGGACATCAATTGCAGGATACCCGTTATA
ATATCGGCCATCTAGCTAATATTCAAAACGATGCTGTCAAGGGTATCTTGTCAGCAAAAATCTTAGAAGCTCAGAATAAA
AAGATTGCTGTCAATGTAGAAGTCTCAAGTAAAATACAACTGCCTGAGATGGAGTTGCTTGATTTCATTACCATACTTTC
TATCTTGTGTGATAATGCCATTGAGGCTGCTTTCGAATCATTAAATCCTGAAATTCAGTTAGCCTTTTTTAAGAAAAATG
GCAGTATAGTCTTTATCATTCAGAATTCCACCAAAGAAAAACAAATAGATGTGAGTAAAATTTTTAAAGAAAACTATTCC
ACTAAAGGCTCCAATCGCGGTATTGGTTTAGCAAAGGTGAATCATATTCTTGAACATTATCCCAAAACCAGTTTACAAAC
AAGCAATCATCATCATTTATTCAAGCAACTCCTAATAATAAAATAG

Domains

Predicted by InterProScan.

GHKL domain (HATPase_c_5)

(337-440)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DS94

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/blpH Streptococcus mutans UA159

100

100

1