Detailed information NTG0584427

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU522_RS00150
• Genome accession: NZ_CP077877
• Coordinates: 28268..29311 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 357
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 23268..34311

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU522_RS00120 (KU522_00120)	-	23686..24942 (-)	1257	WP_001795438.1	aminopeptidase	-
KU522_RS00125 (KU522_00125)	-	24945..25145 (-)	201	WP_000180461.1	DUF1128 family protein	-
KU522_RS00130 (KU522_00130)	-	25292..25756 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU522_RS00135 (KU522_00135)	-	25763..26038 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU522_RS00140 (KU522_00140)	-	26316..27533 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU522_RS00145 (KU522_00145)	vraR	27649..28278 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
KU522_RS00150 (KU522_00150)	vraS	28268..29311 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU522_RS00155 (KU522_00155)	liaF	29308..30009 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU522_RS00160 (KU522_00160)	-	30024..30410 (-)	387	WP_031896188.1	hypothetical protein	-
KU522_RS00165 (KU522_00165)	map	30627..31385 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU522_RS00170 (KU522_00170)	-	31913..32899 (+)	987	WP_000999713.1	FUSC family protein	-
KU522_RS00175 (KU522_00175)	-	33389..33802 (-)	414	WP_001549145.1	hypothetical protein	-
KU522_RS00180 (KU522_00180)	-	33831..33941 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584427 KU522_RS00150 WP_001017131.1 28268..29311(-) (vraS) [Staphylococcus aureus strain 357]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584427 KU522_RS00150 WP_001017131.1 28268..29311(-) (vraS) [Staphylococcus aureus strain 357]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1