Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   I6L88_RS00345 Genome accession   NZ_CP077404
Coordinates   66977..67729 (+) Length   250 a.a.
NCBI ID   WP_002280234.1    Uniprot ID   -
Organism   Streptococcus mutans strain FDAARGOS 1458     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 61977..72729
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6L88_RS00325 (I6L88_00325) dnaI 62888..63787 (+) 900 WP_002280235.1 primosomal protein DnaI -
  I6L88_RS00330 (I6L88_00330) der 63800..65110 (+) 1311 WP_002265452.1 ribosome biogenesis GTPase Der -
  I6L88_RS00335 (I6L88_00335) - 65185..65811 (+) 627 WP_002265453.1 hypothetical protein -
  I6L88_RS00340 (I6L88_00340) - 65858..66496 (+) 639 WP_002265117.1 VTT domain-containing protein -
  I6L88_RS00345 (I6L88_00345) comE/blpR 66977..67729 (+) 753 WP_002280234.1 response regulator transcription factor Regulator
  I6L88_RS00350 (I6L88_00350) comD/blpH 67726..69051 (+) 1326 WP_002280233.1 sensor histidine kinase Regulator
  I6L88_RS00355 (I6L88_00355) comC/blpC 69188..69334 (-) 147 WP_002280232.1 ComC/BlpC family leader-containing pheromone/bacteriocin Regulator
  I6L88_RS00360 (I6L88_00360) - 69601..69822 (+) 222 WP_002312090.1 Blp family class II bacteriocin -
  I6L88_RS00365 (I6L88_00365) - 69853..70071 (+) 219 WP_025985888.1 Blp family class II bacteriocin -
  I6L88_RS00370 (I6L88_00370) - 70157..70561 (+) 405 WP_002280427.1 hypothetical protein -
  I6L88_RS09970 - 70684..70896 (-) 213 Protein_74 IS3 family transposase -
  I6L88_RS00375 (I6L88_00375) - 71336..71500 (+) 165 WP_002265308.1 hypothetical protein -
  I6L88_RS00380 (I6L88_00380) - 71884..72075 (+) 192 WP_002312088.1 Blp family class II bacteriocin -
  I6L88_RS00385 (I6L88_00385) - 72239..72427 (+) 189 WP_002280338.1 Blp family class II bacteriocin -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29361.71 Da        Isoelectric Point: 8.2551

>NTDB_id=581282 I6L88_RS00345 WP_002280234.1 66977..67729(+) (comE/blpR) [Streptococcus mutans strain FDAARGOS 1458]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDTIPEKGSHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIESALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=581282 I6L88_RS00345 WP_002280234.1 66977..67729(+) (comE/blpR) [Streptococcus mutans strain FDAARGOS 1458]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAGCAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGATACTATCCCTGAAAAGGGCAGTC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCGGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATCAGCGCTGTATTATGCTATGGAAAACA
GCCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTCTACGGCAGTAT
GACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAACGCTTGGCCTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(153-242)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

99.2

100

0.992
  comE/comE1 Streptococcus equinus JB1

46.473

96.4

0.448
  comE Streptococcus mitis NCTC 12261

41.7

98.8

0.412
  comE Streptococcus infantis strain Atu-4

41.7

98.8

0.412
  comE Streptococcus pneumoniae Rx1

41.296

98.8

0.408
  comE Streptococcus mitis SK321

41.296

98.8

0.408
  comE Streptococcus pneumoniae D39

41.296

98.8

0.408
  comE Streptococcus pneumoniae R6

41.296

98.8

0.408
  comE Streptococcus pneumoniae TIGR4

41.296

98.8

0.408
  comE/comE2 Streptococcus equinus JB1

40.664

96.4

0.392
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.551

98

0.368
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.551

98

0.368