Detailed information NTG0580230

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: I6L85_RS00075
• Genome accession: NZ_CP077248
• Coordinates: 14447..15214 (+)
• Length: 255 a.a.
• NCBI ID: WP_008808031.1
• Uniprot ID: P75031
• Organism: Streptococcus gordonii strain FDAARGOS 1455
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 9447..20214

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6L85_RS00045 (I6L85_00045)	spo0J	9930..10694 (-)	765	WP_111724269.1	ParB/RepB/Spo0J family partition protein	Regulator
I6L85_RS00050 (I6L85_00050)	htrA	10760..11953 (-)	1194	WP_111724268.1	S1C family serine protease	Regulator
I6L85_RS00055 (I6L85_00055)	rlmH	12147..12626 (+)	480	WP_008808034.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
I6L85_RS00065 (I6L85_00065)	comC/comC1	12912..13076 (+)	165	WP_080998577.1	bacteriocin	Regulator
I6L85_RS00070 (I6L85_00070)	comD/comD1	13089..14450 (+)	1362	WP_269459934.1	competence system sensor histidine kinase ComD	Regulator
I6L85_RS00075 (I6L85_00075)	comE/comE2	14447..15214 (+)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
I6L85_RS00090 (I6L85_00090)	ychF	15536..16651 (+)	1116	WP_008808030.1	redox-regulated ATPase YchF	-
I6L85_RS00095 (I6L85_00095)	pth	16724..17293 (+)	570	WP_111724267.1	aminoacyl-tRNA hydrolase	-

Sequence

Protein

• Length: 255 a.a.
• Molecular weight: 30225.48 Da
• Isoelectric Point: 7.0651

>NTDB_id=580230 I6L85_RS00075 WP_008808031.1 14447..15214(+) (comE/comE2) [Streptococcus gordonii strain FDAARGOS 1455]
MKVLVLEDTIEHQVRIENVFEEISRELNLEIKAKVTGKIHEFKEYVESDEVNQLYFLDIDIKGEEQKGLEMAQFIRQHNP
YAIIVFVTSHSEFATLTFKYKVSALDFIDKDINDNSFKKRVKDCIVYTRNNLIENTDIVDFFEYSFRGNEIRIPFRDILY
IETTGSPYKLRVVGKNFFKEFYGTIAEIQEQDKELGYFFSPHKSYLSNISNISGYDKKTKDVLYYDGHRSPISRLRVRYL
KEILKAKSKKEENKK

Nucleotide

• Length: 768 bp

>NTDB_id=580230 I6L85_RS00075 WP_008808031.1 14447..15214(+) (comE/comE2) [Streptococcus gordonii strain FDAARGOS 1455]
ATGAAAGTATTAGTGCTAGAGGATACTATTGAACATCAAGTGAGAATTGAAAATGTCTTCGAAGAAATTTCTCGCGAACT
AAATCTTGAAATTAAAGCAAAAGTAACAGGAAAAATTCATGAATTTAAAGAATATGTTGAGTCAGACGAGGTGAATCAAC
TCTATTTCTTAGATATAGATATCAAAGGAGAAGAACAAAAAGGTCTAGAAATGGCGCAATTTATCCGCCAACATAATCCT
TATGCTATCATTGTTTTTGTTACGAGTCATTCAGAATTTGCGACCTTAACTTTTAAGTATAAAGTATCAGCGTTAGATTT
TATAGATAAAGACATAAATGATAATTCTTTTAAGAAAAGAGTTAAAGATTGCATCGTTTATACACGAAATAATTTAATTG
AAAATACAGATATTGTTGACTTTTTTGAGTATAGTTTTAGAGGAAACGAAATTCGAATTCCTTTTAGAGATATTCTATAT
ATTGAGACGACAGGAAGCCCTTATAAATTAAGAGTTGTTGGAAAAAATTTCTTTAAGGAATTTTATGGGACAATAGCAGA
AATTCAAGAACAAGATAAAGAACTTGGATATTTTTTCTCACCACATAAGTCATACCTATCTAATATTAGCAACATTAGTG
GATACGACAAAAAGACAAAAGATGTTTTGTATTATGATGGTCATCGTTCACCAATTTCTCGATTACGTGTCAGATACTTG
AAAGAAATACTGAAAGCCAAAAGTAAAAAAGAAGAAAATAAAAAATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: P75031

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	100	100	1
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	100	100	1
comE	Streptococcus infantis strain Atu-4	64	98.039	0.627
comE	Streptococcus mitis NCTC 12261	64	98.039	0.627
comE	Streptococcus mitis SK321	63.2	98.039	0.62
comE	Streptococcus pneumoniae Rx1	62.8	98.039	0.616
comE	Streptococcus pneumoniae D39	62.8	98.039	0.616
comE	Streptococcus pneumoniae R6	62.8	98.039	0.616
comE	Streptococcus pneumoniae TIGR4	62.8	98.039	0.616
comE/blpR	Streptococcus mutans UA159	37.551	96.078	0.361