Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6L85_RS00050 Genome accession   NZ_CP077248
Coordinates   10760..11953 (-) Length   397 a.a.
NCBI ID   WP_111724268.1    Uniprot ID   -
Organism   Streptococcus gordonii strain FDAARGOS 1455     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 5760..16953
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6L85_RS00025 (I6L85_00025) - 6343..6861 (+) 519 WP_111723073.1 DUF1307 domain-containing protein -
  I6L85_RS00030 (I6L85_00030) - 6880..7083 (-) 204 WP_008808039.1 DUF951 domain-containing protein -
  I6L85_RS00035 (I6L85_00035) dnaN 7083..8219 (-) 1137 WP_111723072.1 DNA polymerase III subunit beta -
  I6L85_RS00040 (I6L85_00040) dnaA 8375..9727 (-) 1353 WP_111723071.1 chromosomal replication initiator protein DnaA -
  I6L85_RS00045 (I6L85_00045) spo0J 9930..10694 (-) 765 WP_111724269.1 ParB/RepB/Spo0J family partition protein Regulator
  I6L85_RS00050 (I6L85_00050) htrA 10760..11953 (-) 1194 WP_111724268.1 S1C family serine protease Regulator
  I6L85_RS00055 (I6L85_00055) rlmH 12147..12626 (+) 480 WP_008808034.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6L85_RS00065 (I6L85_00065) comC/comC1 12912..13076 (+) 165 WP_080998577.1 bacteriocin Regulator
  I6L85_RS00070 (I6L85_00070) comD/comD1 13089..14450 (+) 1362 WP_269459934.1 competence system sensor histidine kinase ComD Regulator
  I6L85_RS00075 (I6L85_00075) comE/comE2 14447..15214 (+) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  I6L85_RS00090 (I6L85_00090) ychF 15536..16651 (+) 1116 WP_008808030.1 redox-regulated ATPase YchF -

Sequence

Protein


Download         Length: 397 a.a.        Molecular weight: 42156.84 Da        Isoelectric Point: 5.2632

>NTDB_id=580227 I6L85_RS00050 WP_111724268.1 10760..11953(-) (htrA) [Streptococcus gordonii strain FDAARGOS 1455]
MKNSSNFFKKTLQVFIVLFVGFIGGVAGTWGLSYFSTPHSATNNNQKTATTITTSYKNSNSTTKAVDKVKDAVVSVITYS
ESSSDAIFDNNNSGNENDQVASEGSGVIYRKDKDYAYLVTNTHVINGAKKVDIRLADGNKVPGEIVGTDTYSDISVVRIP
ADKVKNVAEFGDSSKLTVGETAIAIGSPLGSDYANTVTQGIVSSLSRNVSSRSEDGQTIATQAIQTDAAINPGNSGGPLV
NIQGQVIGITSSKIANTNNGSTSVEGMGFAIPSNDVVSIIEQLEKNGKVIRPALGIQMVNLSSLSSSSSDRLKLPDNIKN
GVVVRSTQTGMPADGKLEKYDVITKIDDTEISSASDIQSALYKHSINEEIKVTYYRDGKEQTTTIKLTKSTDDLSSE

Nucleotide


Download         Length: 1194 bp        

>NTDB_id=580227 I6L85_RS00050 WP_111724268.1 10760..11953(-) (htrA) [Streptococcus gordonii strain FDAARGOS 1455]
ATGAAAAATTCTTCAAATTTCTTCAAAAAAACATTGCAAGTTTTCATTGTCTTGTTTGTTGGTTTTATAGGTGGTGTTGC
TGGAACATGGGGACTTTCTTATTTTTCAACACCTCACTCAGCCACAAATAATAATCAGAAAACAGCTACTACAATAACAA
CATCCTATAAAAATAGTAATTCTACAACAAAGGCTGTTGATAAAGTTAAAGACGCAGTTGTCTCTGTCATTACATATTCT
GAATCTAGTTCAGATGCTATTTTTGACAACAATAATTCAGGAAATGAAAATGATCAAGTAGCTAGCGAAGGATCTGGTGT
TATCTATAGAAAAGATAAGGATTATGCTTACTTAGTTACCAATACACACGTTATCAATGGAGCAAAAAAAGTTGATATCC
GTCTGGCTGATGGGAATAAGGTTCCTGGTGAAATAGTCGGGACTGATACATATTCTGATATTTCTGTAGTCAGAATTCCT
GCTGATAAGGTTAAAAATGTAGCAGAATTTGGAGATTCTAGTAAATTAACCGTTGGAGAAACTGCCATTGCAATCGGAAG
CCCTCTTGGTTCTGATTATGCTAATACAGTGACTCAGGGAATTGTTTCTAGTCTAAGCCGTAATGTTTCTTCACGATCAG
AAGATGGTCAGACAATTGCTACCCAAGCTATTCAAACTGATGCAGCAATTAATCCAGGTAACTCTGGTGGTCCTCTTGTA
AACATTCAAGGTCAAGTTATTGGTATTACCTCTAGTAAAATTGCTAACACCAATAATGGTAGTACTTCTGTTGAGGGAAT
GGGATTTGCAATCCCATCCAATGATGTTGTAAGTATCATTGAACAATTAGAAAAGAATGGAAAAGTCATTCGACCAGCAT
TAGGAATTCAAATGGTCAACTTAAGTAGTTTATCTTCTTCAAGCTCTGATCGATTAAAACTTCCAGACAATATTAAGAAT
GGTGTCGTTGTTCGTTCCACACAAACTGGAATGCCTGCTGATGGTAAGTTAGAAAAATATGATGTGATTACAAAAATTGA
TGATACAGAAATATCATCTGCTAGTGATATCCAATCAGCTCTTTATAAACATTCGATTAATGAAGAAATAAAAGTTACTT
ATTACCGTGATGGAAAAGAGCAAACAACAACTATTAAACTAACTAAATCAACTGATGATTTAAGCTCTGAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

Peptidase family M50 (Peptidase_M50)

(235-391)

PDZ domain (PDZ_2)

(292-387)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

98.237

100

0.982
  htrA Streptococcus mitis NCTC 12261

65.829

100

0.66
  htrA Streptococcus pneumoniae Rx1

65.909

99.748

0.657
  htrA Streptococcus pneumoniae D39

65.909

99.748

0.657
  htrA Streptococcus pneumoniae R6

65.909

99.748

0.657
  htrA Streptococcus pneumoniae TIGR4

65.909

99.748

0.657
  htrA Streptococcus mutans UA159

56.14

100

0.564