Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGC/cglC   Type   Machinery gene
Locus tag   J4Q32_RS09930 Genome accession   NZ_CP071916
Coordinates   1911039..1911305 (-) Length   88 a.a.
NCBI ID   WP_000962026.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 19A-19087     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1911796..1958995 1911039..1911305 flank 491


Gene organization within MGE regions


Location: 1911039..1958995
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  J4Q32_RS09930 (J4Q32_09920) comGC/cglC 1911039..1911305 (-) 267 WP_000962026.1 competence type IV pilus major pilin ComGC Machinery gene
  J4Q32_RS09935 (J4Q32_09925) - 1911307..1911564 (-) 258 WP_000698513.1 hypothetical protein -
  J4Q32_RS09940 (J4Q32_09930) - 1911796..1912752 (-) 957 WP_233923013.1 N-acetylmuramoyl-L-alanine amidase family protein -
  J4Q32_RS09945 (J4Q32_09935) - 1912755..1913090 (-) 336 WP_050200954.1 phage holin -
  J4Q32_RS09950 (J4Q32_09940) - 1913094..1913510 (-) 417 WP_001165344.1 phage holin family protein -
  J4Q32_RS09955 (J4Q32_09945) - 1913520..1913870 (-) 351 WP_050200952.1 hypothetical protein -
  J4Q32_RS09960 (J4Q32_09950) - 1913873..1914076 (-) 204 WP_001091109.1 hypothetical protein -
  J4Q32_RS11515 - 1914057..1914173 (-) 117 WP_001063633.1 hypothetical protein -
  J4Q32_RS09965 - 1914170..1923124 (-) 8955 WP_233922963.1 tail fiber domain-containing protein -
  J4Q32_RS09970 (J4Q32_09970) - 1923129..1923479 (-) 351 WP_000068025.1 DUF6711 family protein -
  J4Q32_RS09975 (J4Q32_09975) - 1923488..1927141 (-) 3654 WP_233922964.1 hypothetical protein -
  J4Q32_RS09980 (J4Q32_09980) - 1927128..1927478 (-) 351 WP_000478016.1 hypothetical protein -
  J4Q32_RS09985 (J4Q32_09985) - 1927517..1927897 (-) 381 WP_001185632.1 DUF6096 family protein -
  J4Q32_RS09990 (J4Q32_09990) - 1927902..1928315 (-) 414 WP_000880676.1 phage tail tube protein -
  J4Q32_RS09995 (J4Q32_09995) - 1928318..1928686 (-) 369 WP_000608235.1 hypothetical protein -
  J4Q32_RS10000 (J4Q32_10000) - 1928683..1929198 (-) 516 WP_044812726.1 HK97-gp10 family putative phage morphogenesis protein -
  J4Q32_RS10005 (J4Q32_10005) - 1929173..1929511 (-) 339 WP_000478943.1 hypothetical protein -
  J4Q32_RS10010 (J4Q32_10010) - 1929492..1929803 (-) 312 WP_000021221.1 phage head-tail connector protein -
  J4Q32_RS10015 (J4Q32_10015) - 1929805..1929993 (-) 189 WP_000669348.1 hypothetical protein -
  J4Q32_RS10020 (J4Q32_10020) - 1929983..1930165 (-) 183 WP_000054934.1 Rho termination factor N-terminal domain-containing protein -
  J4Q32_RS10025 (J4Q32_10025) - 1930177..1931022 (-) 846 WP_000123890.1 N4-gp56 family major capsid protein -
  J4Q32_RS10030 (J4Q32_10030) - 1931029..1931613 (-) 585 WP_001288026.1 DUF4355 domain-containing protein -
  J4Q32_RS10035 (J4Q32_10035) - 1931830..1932081 (-) 252 WP_000890163.1 DUF6275 family protein -
  J4Q32_RS10040 (J4Q32_10040) - 1932083..1932328 (-) 246 WP_050221455.1 hypothetical protein -
  J4Q32_RS10045 (J4Q32_10045) - 1932380..1932607 (-) 228 WP_050110656.1 hypothetical protein -
  J4Q32_RS10050 (J4Q32_10050) - 1932595..1933998 (-) 1404 WP_225791470.1 minor capsid protein -
  J4Q32_RS10055 (J4Q32_10055) - 1933907..1935376 (-) 1470 WP_078730733.1 phage portal protein -
  J4Q32_RS10060 (J4Q32_10060) - 1935388..1936686 (-) 1299 WP_000084426.1 PBSX family phage terminase large subunit -
  J4Q32_RS10065 (J4Q32_10065) - 1936664..1937104 (-) 441 WP_001859583.1 terminase small subunit -
  J4Q32_RS10075 (J4Q32_10075) - 1937578..1938000 (-) 423 WP_001030244.1 DUF1492 domain-containing protein -
  J4Q32_RS10080 (J4Q32_10080) - 1938070..1938435 (-) 366 WP_000802874.1 hypothetical protein -
  J4Q32_RS10085 (J4Q32_10085) - 1938432..1938752 (-) 321 WP_320408135.1 3-dehydroquinate synthase -
  J4Q32_RS10090 (J4Q32_10090) - 1939008..1939187 (-) 180 WP_001042650.1 hypothetical protein -
  J4Q32_RS10095 (J4Q32_10095) - 1939180..1939674 (-) 495 WP_233922966.1 YopX family protein -
  J4Q32_RS10100 (J4Q32_10100) - 1939671..1940189 (-) 519 WP_233922967.1 DUF1642 domain-containing protein -
  J4Q32_RS10105 (J4Q32_10105) - 1940191..1940508 (-) 318 WP_174222359.1 hypothetical protein -
  J4Q32_RS10110 (J4Q32_10110) - 1940533..1940715 (-) 183 WP_000796349.1 hypothetical protein -
  J4Q32_RS10115 (J4Q32_10115) - 1940731..1941162 (-) 432 WP_000779143.1 RusA family crossover junction endodeoxyribonuclease -
  J4Q32_RS10120 (J4Q32_10120) - 1941159..1941488 (-) 330 WP_050210841.1 hypothetical protein -
  J4Q32_RS10125 (J4Q32_10125) - 1941502..1941711 (-) 210 WP_000455269.1 hypothetical protein -
  J4Q32_RS10130 (J4Q32_10130) - 1941713..1942408 (-) 696 WP_050099130.1 site-specific DNA-methyltransferase -
  J4Q32_RS10135 (J4Q32_10135) ssbA 1942421..1942837 (-) 417 WP_050201984.1 single-stranded DNA-binding protein Machinery gene
  J4Q32_RS10140 (J4Q32_10140) - 1942827..1942970 (-) 144 WP_153277088.1 hypothetical protein -
  J4Q32_RS10145 (J4Q32_10145) - 1942973..1944037 (-) 1065 WP_233922968.1 DUF1351 domain-containing protein -
  J4Q32_RS10150 (J4Q32_10150) bet 1944047..1944799 (-) 753 WP_050263779.1 phage recombination protein Bet -
  J4Q32_RS10155 (J4Q32_10155) - 1944817..1945002 (-) 186 WP_000746960.1 hypothetical protein -
  J4Q32_RS10160 (J4Q32_10160) - 1945171..1945314 (-) 144 WP_001862963.1 hypothetical protein -
  J4Q32_RS10165 (J4Q32_10165) - 1945301..1945561 (-) 261 WP_000471463.1 hypothetical protein -
  J4Q32_RS10170 (J4Q32_10170) - 1945574..1945828 (-) 255 WP_000275521.1 hypothetical protein -
  J4Q32_RS10175 (J4Q32_10175) - 1945829..1946050 (-) 222 WP_001864263.1 hypothetical protein -
  J4Q32_RS10180 (J4Q32_10180) - 1946050..1946211 (-) 162 WP_000823399.1 BOW99_gp33 family protein -
  J4Q32_RS10185 (J4Q32_10185) - 1946276..1946419 (-) 144 WP_001862958.1 hypothetical protein -
  J4Q32_RS10190 (J4Q32_10190) - 1946536..1946760 (+) 225 WP_000517704.1 DUF2188 domain-containing protein -
  J4Q32_RS10195 (J4Q32_10195) - 1946757..1946939 (-) 183 WP_001247797.1 hypothetical protein -
  J4Q32_RS10200 (J4Q32_10200) - 1947121..1947399 (-) 279 WP_000261154.1 HTH domain-containing protein -
  J4Q32_RS10205 (J4Q32_10205) - 1947566..1947802 (-) 237 WP_001157069.1 hypothetical protein -
  J4Q32_RS11360 - 1947876..1948001 (+) 126 WP_257885839.1 hypothetical protein -
  J4Q32_RS10210 (J4Q32_10215) - 1947994..1948293 (-) 300 WP_191855094.1 hypothetical protein -
  J4Q32_RS10215 (J4Q32_10220) - 1948368..1948643 (-) 276 WP_050202804.1 hypothetical protein -
  J4Q32_RS10220 (J4Q32_10225) - 1948804..1949556 (+) 753 WP_233922969.1 XRE family transcriptional regulator -
  J4Q32_RS10225 (J4Q32_10230) - 1949558..1950322 (+) 765 WP_219576745.1 hypothetical protein -
  J4Q32_RS10230 (J4Q32_10235) - 1950629..1952074 (+) 1446 WP_219576746.1 recombinase family protein -
  J4Q32_RS10240 (J4Q32_10245) comGB/cglB 1952156..1953172 (-) 1017 WP_013193332.1 competence type IV pilus assembly protein ComGB Machinery gene
  J4Q32_RS10245 (J4Q32_10250) comGA/cglA/cilD 1953120..1954061 (-) 942 WP_000249567.1 competence type IV pilus ATPase ComGA Machinery gene
  J4Q32_RS10250 (J4Q32_10255) - 1954137..1954502 (-) 366 WP_000286415.1 DUF1033 family protein -
  J4Q32_RS10255 (J4Q32_10260) - 1954653..1955711 (-) 1059 WP_000649468.1 zinc-dependent alcohol dehydrogenase family protein -
  J4Q32_RS10260 (J4Q32_10265) nagA 1955874..1957025 (-) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -
  J4Q32_RS10265 (J4Q32_10270) - 1957178..1958995 (-) 1818 WP_001220865.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 88 a.a.        Molecular weight: 9818.31 Da        Isoelectric Point: 7.0116

>NTDB_id=548980 J4Q32_RS09930 WP_000962026.1 1911039..1911305(-) (comGC/cglC) [Streptococcus pneumoniae strain 19A-19087]
MLVVLLIISVLFLLFVPNLTKQKEAVNDKGKAAVVKVVESQAELYSLEKNEDASLSKLQADGRITEEQAKAYKEYHDKNG
VANRKVND

Nucleotide


Download         Length: 267 bp        

>NTDB_id=548980 J4Q32_RS09930 WP_000962026.1 1911039..1911305(-) (comGC/cglC) [Streptococcus pneumoniae strain 19A-19087]
ATGTTGGTGGTCTTGCTGATTATCAGCGTGCTTTTCTTGCTCTTTGTACCTAATCTGACCAAGCAAAAAGAGGCAGTCAA
TGACAAAGGAAAAGCAGCTGTTGTTAAGGTGGTGGAAAGCCAGGCAGAACTTTATAGCTTGGAAAAGAATGAAGATGCTA
GCCTAAGCAAGTTACAAGCAGATGGGCGAATCACGGAAGAACAGGCTAAAGCTTATAAAGAATACCATGATAAAAATGGA
GTAGCAAATCGTAAAGTCAATGATTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGC/cglC Streptococcus pneumoniae Rx1

97.727

100

0.977
  comGC/cglC Streptococcus pneumoniae D39

97.727

100

0.977
  comGC/cglC Streptococcus pneumoniae R6

97.727

100

0.977
  comGC/cglC Streptococcus pneumoniae TIGR4

96.591

100

0.966
  comGC/cglC Streptococcus mitis SK321

93.243

84.091

0.784
  comGC/cglC Streptococcus mitis NCTC 12261

91.176

77.273

0.705
  comYC Streptococcus gordonii str. Challis substr. CH1

72.5

90.909

0.659
  comYC Streptococcus suis isolate S10

68.056

81.818

0.557
  comYC Streptococcus mutans UA140

61.429

79.545

0.489
  comYC Streptococcus mutans UA159

61.429

79.545

0.489
  comGC Lactococcus lactis subsp. cremoris KW2

50.667

85.227

0.432
  comGC Staphylococcus aureus MW2

47.826

78.409

0.375
  comGC Staphylococcus aureus N315

47.826

78.409

0.375