Detailed information NTG0053371

Bioinformatically predicted

Overview

• Name: comX/comX2
• Type: Regulator
• Locus tag: HMPREF1038_RS09835
• Genome accession: NC_018630
• Coordinates: 1824128..1824607 (-)
• Length: 159 a.a.
• NCBI ID: WP_000588897.1
• Uniprot ID: Q9R2W8
• Organism: Streptococcus pneumoniae gamPNI0373
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1819128..1829607

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF1038_RS09835 (HMPREF1038_02003)	comX/comX2	1824128..1824607 (-)	480	WP_000588897.1	sigma-70 family RNA polymerase sigma factor	Regulator
HMPREF1038_RS09840 (HMPREF1038_02004)	nusG	1824729..1825265 (-)	537	WP_000376736.1	transcription termination/antitermination protein NusG	-
HMPREF1038_RS09845 (HMPREF1038_02005)	secE	1825320..1825496 (-)	177	WP_001210991.1	preprotein translocase subunit SecE	-
HMPREF1038_RS09850	rpmG	1825506..1825658 (-)	153	WP_001809375.1	50S ribosomal protein L33	-
HMPREF1038_RS09855 (HMPREF1038_02006)	pbp2a	1825711..1827906 (-)	2196	WP_000762623.1	penicillin-binding protein PBP2A	-
HMPREF1038_RS09860 (HMPREF1038_02007)	-	1827993..1828868 (+)	876	WP_001844874.1	RluA family pseudouridine synthase	-

Sequence

Protein

• Length: 159 a.a.
• Molecular weight: 19873.52 Da
• Isoelectric Point: 7.3797

>NTDB_id=53371 HMPREF1038_RS09835 WP_000588897.1 1824128..1824607(-) (comX/comX2) [Streptococcus pneumoniae gamPNI0373]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISREEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH

Nucleotide

• Length: 480 bp

>NTDB_id=53371 HMPREF1038_RS09835 WP_000588897.1 1824128..1824607(-) (comX/comX2) [Streptococcus pneumoniae gamPNI0373]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTGTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGACCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGTAGACGATATTCCAC
GTTTAAGGAAATATTTCAAGACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAGCAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGTGAGATCAGTCATCGTATAAGTGAGGGGGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCACTAG

Domains

No domain identified.

3D structure

• AlphaFold DB: Q9R2W8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/comX2	Streptococcus pneumoniae Rx1	100	100	1
comX/comX1	Streptococcus pneumoniae Rx1	100	100	1
comX/comX2	Streptococcus pneumoniae D39	100	100	1
comX/comX1	Streptococcus pneumoniae D39	100	100	1
comX/comX2	Streptococcus pneumoniae R6	100	100	1
comX/comX1	Streptococcus pneumoniae R6	100	100	1
comX/comX2	Streptococcus pneumoniae TIGR4	99.371	100	0.994
comX/comX1	Streptococcus pneumoniae TIGR4	99.371	100	0.994
comX/sigX/comX1/sigX1	Streptococcus mitis NCTC 12261	92.453	100	0.925
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	92.453	100	0.925
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	90.566	100	0.906
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	89.241	99.371	0.887
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comX/sigX	Streptococcus mutans UA159	46	94.34	0.434
comX/sigX	Streptococcus suis isolate S10	45.695	94.969	0.434
comX/sigX	Streptococcus suis D9	45.695	94.969	0.434
comX/sigX	Streptococcus suis P1/7	45.695	94.969	0.434
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	40	94.34	0.377