Detailed information NTG0526188

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: JJN14_RS09970
• Genome accession: NZ_CP067992
• Coordinates: 2028033..2028785 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866073.1
• Uniprot ID: A0A081S8D7
• Organism: Streptococcus mitis strain S022-V7-A3
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2023033..2033785

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JJN14_RS09950 (JJN14_09950)	-	2024465..2027119 (-)	2655	WP_201058572.1	YhgE/Pip domain-containing protein	-
JJN14_RS09955 (JJN14_09955)	-	2027248..2027790 (+)	543	WP_201058573.1	TetR/AcrR family transcriptional regulator	-
JJN14_RS09970 (JJN14_09970)	comE	2028033..2028785 (-)	753	WP_000866073.1	competence system response regulator transcription factor ComE	Regulator
JJN14_RS09975 (JJN14_09975)	comD	2028782..2030107 (-)	1326	WP_201058574.1	competence system sensor histidine kinase ComD	Regulator
JJN14_RS09980 (JJN14_09980)	comC/comC2	2030120..2030242 (-)	123	WP_020902306.1	competence-stimulating peptide ComC	Regulator
JJN14_RS09990 (JJN14_09990)	rlmH	2030524..2031003 (-)	480	WP_064276841.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
JJN14_RS09995 (JJN14_09995)	htrA	2031187..2032368 (+)	1182	WP_153219714.1	S1C family serine protease	Regulator
JJN14_RS10000 (JJN14_10000)	spo0J	2032426..2033184 (+)	759	WP_049509403.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29947.32 Da
• Isoelectric Point: 6.9819

>NTDB_id=526188 JJN14_RS09970 WP_000866073.1 2028033..2028785(-) (comE) [Streptococcus mitis strain S022-V7-A3]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=526188 JJN14_RS09970 WP_000866073.1 2028033..2028785(-) (comE) [Streptococcus mitis strain S022-V7-A3]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTTCTAGATATTGATATTCATGGAATTGAGAAAAAAGGGTTTGAAGTTGCTCAGTTTATTCGTCATCACAATCCT
TATGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCTTAGATTT
TGTTGATAAGGATATCAATGATGAGTTGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTGGTAGATTATTTTGACTATAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGACATTCTGTAT
ATTGAAACGACAGGAGTTTCTCATAAATTGCGCATTATTGGTAAAAATTTTGCAAAAGAGTTTTACGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGGAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTCTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081S8D7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus pneumoniae Rx1	98.4	100	0.984
comE	Streptococcus pneumoniae D39	98.4	100	0.984
comE	Streptococcus pneumoniae R6	98.4	100	0.984
comE	Streptococcus pneumoniae TIGR4	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	92.8	100	0.928
comE/comE2	Streptococcus gordonii strain NCTC7865	64	100	0.64
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	64	100	0.64
comE/blpR	Streptococcus mutans UA159	41.7	98.8	0.412