Detailed information NTG0526191

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: JJN14_RS09995
• Genome accession: NZ_CP067992
• Coordinates: 2031187..2032368 (+)
• Length: 393 a.a.
• NCBI ID: WP_153219714.1
• Uniprot ID: A0A7X1QVY1
• Organism: Streptococcus mitis strain S022-V7-A3
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2026187..2037368

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JJN14_RS09955 (JJN14_09955)	-	2027248..2027790 (+)	543	WP_201058573.1	TetR/AcrR family transcriptional regulator	-
JJN14_RS09970 (JJN14_09970)	comE	2028033..2028785 (-)	753	WP_000866073.1	competence system response regulator transcription factor ComE	Regulator
JJN14_RS09975 (JJN14_09975)	comD	2028782..2030107 (-)	1326	WP_201058574.1	competence system sensor histidine kinase ComD	Regulator
JJN14_RS09980 (JJN14_09980)	comC/comC2	2030120..2030242 (-)	123	WP_020902306.1	competence-stimulating peptide ComC	Regulator
JJN14_RS09990 (JJN14_09990)	rlmH	2030524..2031003 (-)	480	WP_064276841.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
JJN14_RS09995 (JJN14_09995)	htrA	2031187..2032368 (+)	1182	WP_153219714.1	S1C family serine protease	Regulator
JJN14_RS10000 (JJN14_10000)	spo0J	2032426..2033184 (+)	759	WP_049509403.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41753.69 Da
• Isoelectric Point: 6.5090

>NTDB_id=526191 JJN14_RS09995 WP_153219714.1 2031187..2032368(+) (htrA) [Streptococcus mitis strain S022-V7-A3]
MKHLKIFYKKWFQLLVVIVISFFSGALGSFSITQLTQKIGVSSSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTNTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNINTSDIRRLNIPSSVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKDIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=526191 JJN14_RS09995 WP_153219714.1 2031187..2032368(+) (htrA) [Streptococcus mitis strain S022-V7-A3]
ATGAAACATCTAAAAATATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACCCAGCTAACTCAAAAAATTGGTGTAAGTAGCTCGAACAACAATAGCACCATTACACAGACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCAGCA
AACAGACAAAATAGCGTATTTGGTAATGATGATACTAACACAGATTCTCAGCAAATCTCTAGTGAAGGCTCTGGGGTTAT
TTATAAAAAGAATGACAAAGAAGCTTACATTGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGTT
TGTCAGATGGAACTAAAGTACCTGGAGAAATCGTCGGAGCTGATACTTTCTCTGATATCGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCTAGTCTTAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCCATTTCTACGAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTAATCAAT
ATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTTGC
AATCCCTGCAAATGATGCTATCAATATTATTGAACAATTAGAAAAGAACGGAAAAGTGACTCGTCCAGCTTTGGGAATTC
AAATGGTCAATCTCTCAAATATTAATACAAGTGATATTAGAAGACTGAATATTCCAAGCAGTGTAACATCTGGTGTAGTT
GTTCGTTCTGTGCAAAGTAATATGCCTGCAAATGGTCACCTTGAAAAATACGATGTTATTACAAAAGTAGATGACAAAGA
CATCGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATAACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

3D structure

• AlphaFold DB: A0A7X1QVY1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	97.455	100	0.975
htrA	Streptococcus pneumoniae D39	96.692	100	0.967
htrA	Streptococcus pneumoniae R6	96.692	100	0.967
htrA	Streptococcus pneumoniae Rx1	96.692	100	0.967
htrA	Streptococcus pneumoniae TIGR4	96.692	100	0.967
htrA	Streptococcus gordonii str. Challis substr. CH1	65.829	100	0.667
htrA	Streptococcus mutans UA159	54.315	100	0.545