Detailed information NTG0052054

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SMUGS5_RS08595
• Genome accession: NC_018089
• Coordinates: 1777778..1778530 (-)
• Length: 250 a.a.
• NCBI ID: WP_002270252.1
• Uniprot ID: -
• Organism: Streptococcus mutans GS-5
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1772778..1783530

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMUGS5_RS08570 (SMUGS5_08525)	-	1772795..1773199 (-)	405	WP_002274065.1	hypothetical protein	-
SMUGS5_RS08575 (SMUGS5_08530)	-	1773346..1773765 (-)	420	WP_002263913.1	hypothetical protein	-
SMUGS5_RS08580 (SMUGS5_08535)	-	1775146..1775547 (-)	402	WP_002310604.1	hypothetical protein	-
SMUGS5_RS10505	-	1775678..1775907 (-)	230	Protein_1668	Blp family class II bacteriocin	-
SMUGS5_RS08585 (SMUGS5_08550)	comC/blpC	1776174..1776314 (+)	141	WP_002267610.1	ComC/BlpC family leader-containing pheromone/bacteriocin	Regulator
SMUGS5_RS08590 (SMUGS5_08555)	comD/blpH	1776456..1777781 (-)	1326	WP_014835041.1	sensor histidine kinase	Regulator
SMUGS5_RS08595 (SMUGS5_08560)	comE/blpR	1777778..1778530 (-)	753	WP_002270252.1	response regulator transcription factor	Regulator
SMUGS5_RS08600 (SMUGS5_08565)	-	1779001..1779639 (-)	639	WP_002271525.1	VTT domain-containing protein	-
SMUGS5_RS08605 (SMUGS5_08570)	-	1779687..1780313 (-)	627	WP_002265453.1	hypothetical protein	-
SMUGS5_RS08610 (SMUGS5_08575)	der	1780388..1781698 (-)	1311	WP_002280559.1	ribosome biogenesis GTPase Der	-
SMUGS5_RS08615 (SMUGS5_08580)	dnaI	1781711..1782610 (-)	900	WP_002267936.1	primosomal protein DnaI	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29357.76 Da
• Isoelectric Point: 8.2551

>NTDB_id=52054 SMUGS5_RS08595 WP_002270252.1 1777778..1778530(-) (comE/blpR) [Streptococcus mutans GS-5]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDAIPEKGSHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIELALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide

• Length: 753 bp

>NTDB_id=52054 SMUGS5_RS08595 WP_002270252.1 1777778..1778530(-) (comE/blpR) [Streptococcus mutans GS-5]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAACAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGACGCTATCCCTGAAAAGGGCAGTC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCGGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATTAGCGCTGTATTATGCTATGGAAAACA
GTCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTCTACGGCAGTAT
GACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAACGCTTGGCCTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (153-242)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	99.2	100	0.992
comE/comE1	Streptococcus equinus JB1	46.888	96.4	0.452
comE	Streptococcus mitis NCTC 12261	41.7	98.8	0.412
comE	Streptococcus infantis strain Atu-4	41.7	98.8	0.412
comE	Streptococcus pneumoniae D39	41.296	98.8	0.408
comE	Streptococcus pneumoniae Rx1	41.296	98.8	0.408
comE	Streptococcus pneumoniae R6	41.296	98.8	0.408
comE	Streptococcus pneumoniae TIGR4	41.296	98.8	0.408
comE	Streptococcus mitis SK321	41.296	98.8	0.408
comE/comE2	Streptococcus equinus JB1	40.664	96.4	0.392
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.551	98	0.368
comE/comE2	Streptococcus gordonii strain NCTC7865	37.551	98	0.368