Detailed information NTG0516662

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: I6I32_RS05455
• Genome accession: NZ_CP066041
• Coordinates: 1109418..1110170 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866079.1
• Uniprot ID: A0A081R422
• Organism: Streptococcus oralis strain FDAARGOS_1075
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1104418..1115170

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6I32_RS05425 (I6I32_05425)	spo0J	1104998..1105756 (-)	759	WP_198464230.1	ParB/RepB/Spo0J family partition protein	Regulator
I6I32_RS05430 (I6I32_05430)	htrA	1105814..1107010 (-)	1197	WP_125414985.1	S1C family serine protease	Regulator
I6I32_RS05435 (I6I32_05435)	rlmH	1107196..1107675 (+)	480	WP_198464231.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
I6I32_RS05445 (I6I32_05445)	comC/comC2	1107956..1108081 (+)	126	WP_000799678.1	competence-stimulating peptide ComC	Regulator
I6I32_RS05450 (I6I32_05450)	comD	1108102..1109421 (+)	1320	WP_198464232.1	competence system sensor histidine kinase ComD	Regulator
I6I32_RS05455 (I6I32_05455)	comE	1109418..1110170 (+)	753	WP_000866079.1	competence system response regulator transcription factor ComE	Regulator
I6I32_RS05470 (I6I32_05470)	-	1110408..1110950 (-)	543	WP_000665080.1	TetR/AcrR family transcriptional regulator	-
I6I32_RS05475 (I6I32_05475)	-	1111079..1113733 (+)	2655	WP_198464233.1	YhgE/Pip domain-containing protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29884.23 Da
• Isoelectric Point: 6.9755

>NTDB_id=516662 I6I32_RS05455 WP_000866079.1 1109418..1110170(+) (comE) [Streptococcus oralis strain FDAARGOS_1075]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=516662 I6I32_RS05455 WP_000866079.1 1109418..1110170(+) (comE) [Streptococcus oralis strain FDAARGOS_1075]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTAAATGAAATCTCGGAAGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATTGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAGTTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACGTACAAATATCAGGTATCAGCCCTAGATTT
TGTTGATAAAGATATCAATGATGAATTGTTCAAAAAACGCATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTACTTG
AAAATGAAGATGTTGTAGACTATTTTGATTACAACTATAAAGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCTAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGCCCGATTACCCGTTTGAAAGTTCGCAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081R422

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.6	100	0.956
comE	Streptococcus mitis SK321	94.8	100	0.948
comE	Streptococcus pneumoniae Rx1	94	100	0.94
comE	Streptococcus pneumoniae D39	94	100	0.94
comE	Streptococcus pneumoniae R6	94	100	0.94
comE	Streptococcus pneumoniae TIGR4	94	100	0.94
comE	Streptococcus infantis strain Atu-4	93.6	100	0.936
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4