Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6I32_RS05430 Genome accession   NZ_CP066041
Coordinates   1105814..1107010 (-) Length   398 a.a.
NCBI ID   WP_125414985.1    Uniprot ID   -
Organism   Streptococcus oralis strain FDAARGOS_1075     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1100814..1112010
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6I32_RS05410 (I6I32_05410) - 1101866..1102060 (-) 195 WP_000285184.1 DUF951 domain-containing protein -
  I6I32_RS05415 (I6I32_05415) dnaN 1102125..1103261 (-) 1137 WP_000581146.1 DNA polymerase III subunit beta -
  I6I32_RS05420 (I6I32_05420) dnaA 1103420..1104781 (-) 1362 WP_000660623.1 chromosomal replication initiator protein DnaA -
  I6I32_RS05425 (I6I32_05425) spo0J 1104998..1105756 (-) 759 WP_198464230.1 ParB/RepB/Spo0J family partition protein Regulator
  I6I32_RS05430 (I6I32_05430) htrA 1105814..1107010 (-) 1197 WP_125414985.1 S1C family serine protease Regulator
  I6I32_RS05435 (I6I32_05435) rlmH 1107196..1107675 (+) 480 WP_198464231.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6I32_RS05445 (I6I32_05445) comC/comC2 1107956..1108081 (+) 126 WP_000799678.1 competence-stimulating peptide ComC Regulator
  I6I32_RS05450 (I6I32_05450) comD 1108102..1109421 (+) 1320 WP_198464232.1 competence system sensor histidine kinase ComD Regulator
  I6I32_RS05455 (I6I32_05455) comE 1109418..1110170 (+) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  I6I32_RS05470 (I6I32_05470) - 1110408..1110950 (-) 543 WP_000665080.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 398 a.a.        Molecular weight: 42013.81 Da        Isoelectric Point: 6.6581

>NTDB_id=516659 I6I32_RS05430 WP_125414985.1 1105814..1107010(-) (htrA) [Streptococcus oralis strain FDAARGOS_1075]
MKHLQKFYKKGVKVLVIILIGFLSGALGSFVTLQLYQKQGNQATNNNSGTVTQTSYKNENSTTQAVNKVKDAVVSIITYS
SSSSRQSSVFNGDETNSDSDNQQIASEGSGVIYKKDDKDAYLVTNTHVINGASKVDIRLADGTKVPGEIVGSDTFSDIAV
VKISSEKVTTVAEFGDSSQLSVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSG
GPLVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESNGKVTRPALGIQMVNLSNVGASDLRKLNIPSGL
TSGVVVRSVQNNMPANGHLQKYDVITKVDDKEIASSTDLQHALYNHAIGDTIKVTYYRNGKEETTSIKLDKNSSDLES

Nucleotide


Download         Length: 1197 bp        

>NTDB_id=516659 I6I32_RS05430 WP_125414985.1 1105814..1107010(-) (htrA) [Streptococcus oralis strain FDAARGOS_1075]
ATGAAACACTTACAAAAATTTTACAAAAAGGGAGTTAAAGTTCTTGTAATCATTCTAATCGGATTTTTAAGTGGTGCCTT
AGGAAGTTTCGTAACATTACAACTTTATCAAAAACAAGGAAATCAAGCTACGAATAATAATTCTGGCACTGTCACTCAAA
CATCATATAAGAATGAAAATTCAACCACTCAAGCAGTAAATAAAGTTAAGGATGCTGTTGTCTCAATCATTACTTATTCT
TCTTCTAGCAGTAGACAAAGTAGTGTATTTAATGGTGATGAAACTAATTCTGATTCAGACAATCAACAAATCGCAAGTGA
GGGATCAGGTGTTATCTATAAAAAGGATGATAAAGATGCCTATCTTGTAACTAATACTCACGTTATCAATGGAGCTTCAA
AAGTTGATATCCGCTTGGCTGATGGTACCAAGGTTCCTGGTGAAATTGTCGGATCTGATACCTTCTCTGATATTGCTGTC
GTTAAAATTTCTTCAGAAAAAGTTACAACAGTAGCAGAATTTGGGGATTCAAGTCAACTTAGTGTTGGAGAAACAGCGAT
TGCTATCGGTAGTCCTCTAGGTTCAGAATATGCTAACACAGTTACACAGGGGATTATTTCAAGTCTTAATCGAAATGTTT
CTCTAAAATCTGAAGATGGTCAAGCTATTTCAACAAAAGCCATTCAAACAGATACAGCCATTAACCCTGGTAACTCTGGT
GGTCCACTTGTAAACATTCAAGGACAAGTAATTGGTATTACATCAAGTAAAATTGCAAGTAATGGTGGGACATCTGTAGA
AGGTCTTGGTTTTGCAATTCCTTCAAACGATGCACAAAATATCATTAAACAGCTTGAAAGTAATGGTAAAGTGACTCGTC
CAGCTCTTGGGATTCAAATGGTTAATCTGTCAAACGTTGGAGCTAGTGATCTTAGAAAACTTAACATTCCAAGTGGCCTC
ACTTCAGGTGTAGTTGTTCGATCTGTTCAAAACAATATGCCAGCAAATGGACATCTTCAAAAATACGATGTCATTACCAA
AGTTGACGATAAAGAGATTGCTTCATCAACAGACCTACAACACGCTCTTTACAATCATGCTATTGGAGATACTATCAAAG
TAACCTACTACCGTAATGGTAAGGAGGAAACAACCTCAATTAAACTAGATAAGAATTCTAGTGATTTAGAGTCTTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(237-393)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

PDZ domain (PDZ_2)

(294-389)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

83.668

100

0.837
  htrA Streptococcus pneumoniae Rx1

82.915

100

0.829
  htrA Streptococcus pneumoniae D39

82.915

100

0.829
  htrA Streptococcus pneumoniae R6

82.915

100

0.829
  htrA Streptococcus pneumoniae TIGR4

82.915

100

0.829
  htrA Streptococcus gordonii str. Challis substr. CH1

66.915

100

0.676
  htrA Streptococcus mutans UA159

54.822

98.995

0.543